What makes (hydroxy)chloroquine ineffective against COVID-19: Insights from cell biology

Dania Altulea; Sjors Maassen; Maksim V Baranov; Geert van den Bogaart

doi:10.1093/jmcb/mjab016

What makes (hydroxy)chloroquine ineffective against COVID-19: Insights from cell biology

Dania Altulea, Sjors Maassen, Maksim V Baranov, Geert van den Bogaart^*

^*Corresponding author for this work

Molecular Immunology & Microbiology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

Original language	English
Article number	mjab016
Pages (from-to)	175–184
Journal	Journal of Molecular Cell Biology
Volume	13
Issue number	3
Early online date	9-Mar-2021
DOIs	https://doi.org/10.1093/jmcb/mjab016
Publication status	Published - Mar-2021

Keywords

coronavirus
COVID-19
SARS-CoV-2
chloroquine
hydroxychloroquine

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What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biologyFinal publisher's version, 650 KBLicence: CC BY

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title = "What makes (hydroxy)chloroquine ineffective against COVID-19: Insights from cell biology",

abstract = "Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.",

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author = "Dania Altulea and Sjors Maassen and Baranov, {Maksim V} and {van den Bogaart}, Geert",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.",

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T1 - What makes (hydroxy)chloroquine ineffective against COVID-19

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AU - Altulea, Dania

AU - Maassen, Sjors

AU - Baranov, Maksim V

AU - van den Bogaart, Geert

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

PY - 2021/3

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N2 - Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

AB - Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

KW - coronavirus

KW - COVID-19

KW - SARS-CoV-2

KW - chloroquine

KW - hydroxychloroquine

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DO - 10.1093/jmcb/mjab016

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ER -

What makes (hydroxy)chloroquine ineffective against COVID-19: Insights from cell biology

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