Whole body amyloid deposition imaging by 123I-SAP scintigraphy

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Amyloidosis is the name of a group of diseases characterized by extracellular deposition of amyloid fibrils. Deposition of amyloid can be localized or systemic. The 123I-SAP-scan can be used to image extent and distribution of amyloid deposition in patients with systemic AA, AL and ATTR amyloidosis. Images are assessed in a semi-quantitative way by comparing each organ directly or indirectly to the normal blood-pool distribution. Considerable variation is observed between the findings on 123I-SAP-scan and clinical manifestations of organ disease. Regardless, the 123I-SAP-scan still provides both an impression of specific organ involvement as well as a global view of the amyloid load of the whole body. Due to physiological uptake of iodine degradation products in the
stomach or to overwhelming uptake in an enlarged liver or enlarged spleen, visualization of abdominal organs nearby is not always easy and sometimes even impossible. In these cases SPECT (/CT) provides additional anatomical
information to enable a more reliable assessment of such an organ.
Original languageEnglish
Pages (from-to)785-791
Number of pages7
JournalTijdschrift voor Nucleaire Geneeskunde
Issue number4
Publication statusPublished - 2011

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