Whole breast proton irradiation for maximal reduction of heart dose in breast cancer patients

Mirjam E. Mast*, Eline J. Vredeveld, Herman M. Credoe, Jaap van Egmond, Mark W. Heijenbrok, Eugen B. Hug, Patrick Kalk, Loes M. L. van Kempen-Harteveld, Erik W. Korevaar, Hans Paul van der Laan, Johannes A. Langendijk, Hans J. E. Rozema, Anna L. Petoukhova, Jacobus M. Schippers, Henk Struikmans, John H. Maduro

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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PURPOSE: In left-sided breast cancer radiotherapy, tangential intensity modulated radiotherapy combined with breath-hold enables a dose reduction to the heart and left anterior descending (LAD) coronary artery. Aim of this study was to investigate the added value of intensity modulated proton therapy (IMPT) with regard to decreasing the radiation dose to these structures.

METHODS: In this comparative planning study, four treatment plans were generated in 20 patients: an IMPT plan and a tangential IMRT plan, both with breath-hold and free-breathing. At least 97 % of the target volume had to be covered by at least 95 % of the prescribed dose in all cases. Specifically with respect to the heart, the LAD, and the target volumes, we analyzed the maximum doses, the mean doses, and the volumes receiving 5-30 Gy.

RESULTS: As compared to IMRT, IMPT resulted in significant dose reductions to the heart and LAD-region even without breath-hold. In the majority of the IMPT cases, a reduction to almost zero to the heart and LAD-region was obtained. IMPT treatment plans yielded the lowest dose to the lungs.

CONCLUSIONS: With IMPT the dose to the heart and LAD-region could be significantly decreased compared to tangential IMRT with breath-hold. The clinical relevance should be assessed individually based on the baseline risk of cardiac complications in combination with the dose to organs at risk. However, as IMPT for breast cancer is currently not widely available, IMPT should be reserved for patients remaining at high risk for major coronary events.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalBreast Cancer Research and Treatment
Issue number1
Publication statusPublished - Nov-2014


  • Breath-hold
  • Breast cancer
  • IMPT
  • IMRT
  • Heart sparing
  • RISK
  • HOLD


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