Whole-genome characterization and genotyping of global WU polyomavirus strains

Seweryn Bialasiewicz*, Rebecca Rockett, David W. Whiley, Yacine Abed, Tobias Allander, Michael Binks, Guy Boivin, Allen C. Cheng, Ju-Young Chung, Patricia E. Ferguson, Nicole M. Gilroy, Amanda J. Leach, Cecilia Lindau, John W. Rossen, Tania C. Sorrell, Michael D. Nissen, Theo P. Sloots

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    17 Citations (Scopus)

    Abstract

    Exploration of the genetic diversity of WU polyomavirus (WUV) has been limited in terms of the specimen numbers and particularly the sizes of the genomic fragments analyzed. Using whole-genome sequencing of 48 WUV strains collected in four continents over a 5-year period and 16 publicly available whole-genome sequences, we identified three main WUV clades and five subtypes, provisionally termed Ia, Ib, Ic, II, IIIa, and IIIb. Overall nucleotide variation was low (0 to 1.2%). The discriminatory power of the previous VP2 fragment typing method was found to be limited, and a new, larger genotyping region within the VP2/1 interface was proposed.

    Original languageEnglish
    Pages (from-to)6229-6234
    Number of pages6
    JournalJournal of Virology
    Volume84
    Issue number12
    DOIs
    Publication statusPublished - Jun-2010

    Keywords

    • RESPIRATORY-TRACT INFECTIONS
    • KI POLYOMAVIRUSES
    • T-ANTIGEN
    • CHILDREN
    • BK
    • RECOMBINATION
    • EVOLUTIONARY
    • MUTATIONS
    • MIGRATION
    • VIRUS

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