Abstract
The survival of microencapsulated islet grafts is Limited, even if capsular overgrowth is restricted to a small percentage of the capsules. In search of processes other than overgrowth contributing to graft failure, we have studied the islets in non-overgrown capsules at several time points after allotransplantation in the rat. All recipients of islet allografts became normoglycemic. Grafts were retrieved at 4 and 8 weeks after implantation and at 15.3 +/- 2.3 weeks postimplant, 2 weeks after the mean time period at which graft failure occurred. Overgrowth of capsules was complete within 4 weeks postimplant, and it was usually restricted to
| Original language | English |
|---|---|
| Pages (from-to) | 1381-1388 |
| Number of pages | 8 |
| Journal | Diabetes |
| Volume | 48 |
| Issue number | 7 |
| Publication status | Published - Jul-1999 |
Keywords
- BETA-CELL MASS
- ALGINATE-POLYLYSINE MICROCAPSULES
- RAT PANCREATIC-ISLETS
- DIABETIC NUDE-MICE
- BIOARTIFICIAL PANCREAS
- GLUCOSE-INFUSION
- INSULIN RELEASE
- TRANSPLANTATION
- GROWTH
- BIOCOMPATIBILITY