Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?

P De Vos*, JFM Van Straaten, AG Nieuwenhuizen, M de Groot, RJ Ploeg, PJ De Haan, R Van Schilfgaarde

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

170 Citations (Scopus)

Abstract

The survival of microencapsulated islet grafts is Limited, even if capsular overgrowth is restricted to a small percentage of the capsules. In search of processes other than overgrowth contributing to graft failure, we have studied the islets in non-overgrown capsules at several time points after allotransplantation in the rat. All recipients of islet allografts became normoglycemic. Grafts were retrieved at 4 and 8 weeks after implantation and at 15.3 +/- 2.3 weeks postimplant, 2 weeks after the mean time period at which graft failure occurred. Overgrowth of capsules was complete within 4 weeks postimplant, and it was usually restricted to

Original languageEnglish
Pages (from-to)1381-1388
Number of pages8
JournalDiabetes
Volume48
Issue number7
Publication statusPublished - Jul-1999

Keywords

  • BETA-CELL MASS
  • ALGINATE-POLYLYSINE MICROCAPSULES
  • RAT PANCREATIC-ISLETS
  • DIABETIC NUDE-MICE
  • BIOARTIFICIAL PANCREAS
  • GLUCOSE-INFUSION
  • INSULIN RELEASE
  • TRANSPLANTATION
  • GROWTH
  • BIOCOMPATIBILITY

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