@article{e6ce9559657c4246900d0aa480b27ed4,
title = "Young deceased donor kidneys show a survival benefit over older donor kidneys in transplant recipients aged 20-50 years: a study by the ERA-EDTA Registry",
abstract = "Background: Updated survival outcomes of young recipients receiving young or old deceased donor kidneys are required when considering accepting a deceased donor kidney. Methods: We examined outcomes in 6448 European kidney allografts donated from younger (≥20-<50 years) and older (≥50-<70 years) deceased donors when transplanted into very young (≥20-<35 years) or young (≥35-<50 years) adult recipients. Outcomes of first kidney transplantations during 2000-13 and followed-up to 2015 were determined via competing risk, restricted mean survival and Cox regression methods. Results: The 10-year cumulative incidence of graft failure was lowest in very young {22.0% [95% confidence interval (95% CI) 19.1-24.9]} and young [15.3% (95% CI 13.7-16.9)] recipients of younger donor kidneys and highest in very young [36.7% (95% CI 31.9-41.5)] and young [29.2% (95% CI 25.1-33.2)] recipients of older donor kidneys. At the 10-year follow-up, younger donor kidneys had a 1 year (very young) or 9 months (young) longer mean graft survival time compared with older donor kidneys. Graft failure risk in younger donor kidneys was 45% [very young adjusted hazard ratio (aHR) 0.55 (95% CI 0.44-0.68)] and 40% [young aHR 0.60 (95% CI 0.53-0.67)] lower compared with older donor kidneys. A 1-year increase in donor age resulted in a 2% [very young aHR 1.02 (95% CI 1.00-1.04)] or 1% [young aHR 1.01 (95% CI 1.00-1.01)] increase in the 10-year risk of death. Conclusions: Younger donor kidneys show survival benefits over older donor kidneys in adult recipients ages 20-50 years. Updated survival outcomes from older deceased donors are necessary due to advances in transplantation medicine and the increasing role these donors play in organ transplantation.",
author = "Maria Pippias and Jager, {Kitty J} and Anders {\AA}sberg and Berger, {Stefan P} and Patrik Finne and Heaf, {James G} and Julia Kerschbaum and Marko Lempinen and {\'A}ngela Magaz and Massy, {Ziad A} and Stel, {Vianda S}",
note = "Funding Information: We would like to thank the patients and the staff of the dialysis and transplant units for contributing data via their national and regional renal registries. Furthermore, we gratefully acknowledge the following registries and persons for their contributions of data: Austrian Dialysis and Transplant Registry (OEDTR) (R. Kramar); DNS; Dutch Renal Registry (RENINE) (L. Heuveling, S. Vogelaar and M. Hemmelder); Finnish Registry for Kidney Diseases (A. Pylsy and P. H. Groop); Norwegian Renal Registry (T. Leivestad and A. V. Reis{\ae}ter) and the Spanish regional registries of UNIPAR (J. Aranzabal, M. Rodrigo and I. Moina) and Catalonia (RMRC) (E. Arcos, J. Comas and J. Tort) and the other ERA-EDTA registry committee members not mentioned above for their advice in the analysis and the drafting of this paper: C. Zoccali, F. J. Caskey, C. Couchoud, M. Evans, J. W. Groothoff, J. Harambat, F. Jarraya, M. Nordio and I. Rychlik and A. Kramer in the Academic Medical Center Registry office for data collection and management. We would also like to thank the following transplant registries for supplying data for use in this study: Dutch Transplant Foundation (Cynthia Konijn-Janssen), Scandiatransplant and the Finnish Transplantation Registry. The ERA-EDTA Registry is funded by the ERA-EDTA. This article was written by Pippias et al. on behalf of the ERA-EDTA Registry, which is an official body of the ERA-EDTA. Publisher Copyright: {\textcopyright} 2018 The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.",
year = "2020",
month = mar,
day = "1",
doi = "10.1093/ndt/gfy268",
language = "English",
volume = "35",
pages = "534--543",
journal = "Nephrology, Dialysis, Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "3",
}