TY - JOUR
T1 - Young-onset atrial fibrillation
T2 - Sex differences in clinical profile, progression rate and cardiovascular outcome
AU - Marcos, Ernaldo G.
AU - De With, Ruben R.
AU - Mulder, Bart A.
AU - Van Gelder, Isabelle C.
AU - Rienstra, Michiel
PY - 2019/12
Y1 - 2019/12
N2 - Background: Women are underrepresented in major atrial fibrillation (AF) trials. In addition, data regarding clinical profile and outcome in young AF patients is limited. Therefore we aimed to investigate the clinical profile, AF progression rate and cardiovascular outcome between sexes in patients with young-onset AF.Methods: A total of 497 patients with AF-onsetResults: Of 497 patients, 125 (25%) patients were women. Women had more often familial AF (34% versus 22%, P= 0.012) and obesity (26% versus 18%, P= 0.03). Men had more often coronary artery disease (11% versus 5%, P = 0.04), a longer PR interval [163 (148-180) versus 150 (138-167) ms, P <0.001] and higher left ventricular mass index [82 (71-96) versus 72 (61-83) g/m(2), P <0.001]. During a median follow-up of 7.0 (2.7-10.0) years AF progression rate was comparable (HR 2.03 for men versus women, 95%CI 0.924.48; P = 0.08), and no difference in cardiovascular events was observed between women and men (Log rank P-value = 0.07).Conclusions: In young patients with AF, clinical patient profile is different between the sexes but did not result in differences in cardiovascular outcome. (C) 2019 The Authors. Published by Elsevier B.V.
AB - Background: Women are underrepresented in major atrial fibrillation (AF) trials. In addition, data regarding clinical profile and outcome in young AF patients is limited. Therefore we aimed to investigate the clinical profile, AF progression rate and cardiovascular outcome between sexes in patients with young-onset AF.Methods: A total of 497 patients with AF-onsetResults: Of 497 patients, 125 (25%) patients were women. Women had more often familial AF (34% versus 22%, P= 0.012) and obesity (26% versus 18%, P= 0.03). Men had more often coronary artery disease (11% versus 5%, P = 0.04), a longer PR interval [163 (148-180) versus 150 (138-167) ms, P <0.001] and higher left ventricular mass index [82 (71-96) versus 72 (61-83) g/m(2), P <0.001]. During a median follow-up of 7.0 (2.7-10.0) years AF progression rate was comparable (HR 2.03 for men versus women, 95%CI 0.924.48; P = 0.08), and no difference in cardiovascular events was observed between women and men (Log rank P-value = 0.07).Conclusions: In young patients with AF, clinical patient profile is different between the sexes but did not result in differences in cardiovascular outcome. (C) 2019 The Authors. Published by Elsevier B.V.
KW - Atrial fibrillation
KW - Young-onset
KW - Sex
KW - Cardiovascular outcome
KW - RISK-FACTOR
KW - STROKE
KW - MANAGEMENT
KW - COMMUNITY
KW - WOMEN
U2 - 10.1016/j.ijcha.2019.100429
DO - 10.1016/j.ijcha.2019.100429
M3 - Article
SN - 2352-9067
VL - 25
JO - International journal of cardiology. Heart & vasculature
JF - International journal of cardiology. Heart & vasculature
M1 - 100429
ER -