ZENIPLATIN IN PATIENTS WITH ADVANCED OVARIAN-CANCER, A PHASE-II STUDY WITH A 3RD GENERATION PLATINUM COMPLEX

PHB WILLEMSE*, JA GIETEMA, NH MULDER, EGE DEVRIES, S MEIJER, J BOUMA, M BIRKHOFER, RB RASTOGI, DT SLEIJFER

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

25 patients with residual or recurrent ovarian cancer were treated with the new platinum complex zeniplatin (CL 286,558) and 23 patients were evaluable for response. Responses were achieved in 4 patients, 1 complete and 3 partial remissions (16%). 7 patients had stable disease and 12 patients had tumour progression. At a median follow-up of 12 months, the median progression-free survival in responding patients was 11 months and overall survival 81%. The median overall survival of progressive patients amounted to 9 months, indicating the advanced stage of disease in most patients. Renal function was monitored by isotope clearance studies. There was no significant change in effective renal plasma flow (ERPF) or glomerular filtration rate (GFR) in 10 patients who completed six cycles of treatment. 1 patient with a marginal creatinine clearance at baseline suffered from sudden and severe renal failure during the first cycle. Zeniplatin may be active in relapsing, platinum-pretreated patients, and has no direct effects on renal function as measured by isotope clearance. Despite these findings, occasional nephrotoxicity may occur in patients with compromised kidney function, even with prophylactic hydration, and thus limit the application of this new analogue.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalEuropean Journal of Cancer
Volume29A
Issue number3
Publication statusPublished - 1993

Keywords

  • RANDOMIZED TRIAL
  • COMBINATION CHEMOTHERAPY
  • CISPLATIN
  • CARCINOMA
  • CHAP-5

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