Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

EC Zika Consortia Vertical Transmission Study Group; A E Ades; Elizabeth B Brickley; Neal Alexander; David Brown; Thomas Jaenisch; Demócrito de Barros Miranda-Filho; Moritz Pohl; Kerstin D Rosenberger; Antoni Soriano-Arandes; Claire Thorne; Ricardo Arraes de Alencar Ximenes; Thalia Velho Barreto de Araújo; Vivian I Avelino-Silva; Sarah Esperanza Bethencourt Castillo; Victor Hugo Borja Aburto; Patrícia Brasil; Celia D C Christie; Wayner Vieira de Souza; Jose Eduardo Gotuzzo H; Bruno Hoen; Marion Koopmans; Celina Maria Turchi Martelli; Mauro Martins Teixeira; Ernesto T A Marques; Maria Consuelo Miranda; Ulisses Ramos Montarroyos; Maria Elisabeth Moreira; J Glenn Morris; Barry Rockx; Paola Mariela Saba Villarroel; Carmen Soria Segarra; Adriana Tami; Marília Dalva Turchi; Carlo Giaquinto; Xavier de Lamballerie; Annelies Wilder-Smith; Philippe Mayaud

doi:10.1136/bmjopen-2019-035307

Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

EC Zika Consortia Vertical Transmission Study Group, A E Ades, Elizabeth B Brickley, Neal Alexander, David Brown, Thomas Jaenisch, Demócrito de Barros Miranda-Filho, Moritz Pohl, Kerstin D Rosenberger, Antoni Soriano-Arandes, Claire Thorne, Ricardo Arraes de Alencar Ximenes, Thalia Velho Barreto de Araújo, Vivian I Avelino-Silva, Sarah Esperanza Bethencourt Castillo, Victor Hugo Borja Aburto, Patrícia Brasil, Celia D C Christie, Wayner Vieira de Souza, Jose Eduardo Gotuzzo HBruno Hoen, Marion Koopmans, Celina Maria Turchi Martelli, Mauro Martins Teixeira, Ernesto T A Marques, Maria Consuelo Miranda, Ulisses Ramos Montarroyos, Maria Elisabeth Moreira, J Glenn Morris, Barry Rockx, Paola Mariela Saba Villarroel, Carmen Soria Segarra, Adriana Tami, Marília Dalva Turchi, Carlo Giaquinto, Xavier de Lamballerie, Annelies Wilder-Smith, Philippe Mayaud

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

INTRODUCTION: Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.

METHODS AND ANALYSIS: We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.

ETHICS AND DISSEMINATION: Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

Original language	English
Article number	e035307
Number of pages	9
Journal	BMJ Open
Volume	10
Issue number	12
DOIs	https://doi.org/10.1136/bmjopen-2019-035307
Publication status	Published - 15-Dec-2020

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Zika virus infection in pregnancy a protocol for the joint analysis of the prospective cohort studies of the ZIKalliance, ZikaPLAN and ZIKAction consortiaFinal publisher's version, 352 KBLicence: CC BY

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EC Zika Consortia Vertical Transmission Study Group, Ades, A. E., Brickley, E. B., Alexander, N., Brown, D., Jaenisch, T., Miranda-Filho, D. D. B., Pohl, M., Rosenberger, K. D., Soriano-Arandes, A., Thorne, C., Ximenes, R. A. D. A., de Araújo, T. V. B., Avelino-Silva, V. I., Bethencourt Castillo, S. E., Borja Aburto, V. H., Brasil, P., Christie, C. D. C., de Souza, W. V., ... Mayaud, P. (2020). Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia. BMJ Open, 10(12), Article e035307. https://doi.org/10.1136/bmjopen-2019-035307

@article{dc6ccc219704434680e60aa13b58a9cf,

title = "Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia",

abstract = "INTRODUCTION: Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.METHODS AND ANALYSIS: We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.ETHICS AND DISSEMINATION: Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.",

author = "{EC Zika Consortia Vertical Transmission Study Group} and Ades, {A E} and Brickley, {Elizabeth B} and Neal Alexander and David Brown and Thomas Jaenisch and Miranda-Filho, {Dem{\'o}crito de Barros} and Moritz Pohl and Rosenberger, {Kerstin D} and Antoni Soriano-Arandes and Claire Thorne and Ximenes, {Ricardo Arraes de Alencar} and {de Ara{\'u}jo}, {Thalia Velho Barreto} and Avelino-Silva, {Vivian I} and {Bethencourt Castillo}, {Sarah Esperanza} and {Borja Aburto}, {Victor Hugo} and Patr{\'i}cia Brasil and Christie, {Celia D C} and {de Souza}, {Wayner Vieira} and {Gotuzzo H}, {Jose Eduardo} and Bruno Hoen and Marion Koopmans and Martelli, {Celina Maria Turchi} and {Martins Teixeira}, Mauro and Marques, {Ernesto T A} and Miranda, {Maria Consuelo} and Montarroyos, {Ulisses Ramos} and Moreira, {Maria Elisabeth} and Morris, {J Glenn} and Barry Rockx and {Saba Villarroel}, {Paola Mariela} and {Soria Segarra}, Carmen and Adriana Tami and Turchi, {Mar{\'i}lia Dalva} and Carlo Giaquinto and {de Lamballerie}, Xavier and Annelies Wilder-Smith and Philippe Mayaud",

note = "{\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.",

year = "2020",

month = dec,

day = "15",

doi = "10.1136/bmjopen-2019-035307",

language = "English",

volume = "10",

journal = "BMJ Open",

issn = "2044-6055",

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EC Zika Consortia Vertical Transmission Study Group, Ades, AE, Brickley, EB, Alexander, N, Brown, D, Jaenisch, T, Miranda-Filho, DDB, Pohl, M, Rosenberger, KD, Soriano-Arandes, A, Thorne, C, Ximenes, RADA, de Araújo, TVB, Avelino-Silva, VI, Bethencourt Castillo, SE, Borja Aburto, VH, Brasil, P, Christie, CDC, de Souza, WV, Gotuzzo H, JE, Hoen, B, Koopmans, M, Martelli, CMT, Martins Teixeira, M, Marques, ETA, Miranda, MC, Montarroyos, UR, Moreira, ME, Morris, JG, Rockx, B, Saba Villarroel, PM, Soria Segarra, C, Tami, A, Turchi, MD, Giaquinto, C, de Lamballerie, X, Wilder-Smith, A & Mayaud, P 2020, 'Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia', BMJ Open, vol. 10, no. 12, e035307. https://doi.org/10.1136/bmjopen-2019-035307

Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia. / EC Zika Consortia Vertical Transmission Study Group; Ades, A E; Brickley, Elizabeth B et al.
In: BMJ Open, Vol. 10, No. 12, e035307, 15.12.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Zika virus infection in pregnancy

T2 - a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

AU - EC Zika Consortia Vertical Transmission Study Group

AU - Ades, A E

AU - Brickley, Elizabeth B

AU - Alexander, Neal

AU - Brown, David

AU - Jaenisch, Thomas

AU - Miranda-Filho, Demócrito de Barros

AU - Pohl, Moritz

AU - Rosenberger, Kerstin D

AU - Soriano-Arandes, Antoni

AU - Thorne, Claire

AU - Ximenes, Ricardo Arraes de Alencar

AU - de Araújo, Thalia Velho Barreto

AU - Avelino-Silva, Vivian I

AU - Bethencourt Castillo, Sarah Esperanza

AU - Borja Aburto, Victor Hugo

AU - Brasil, Patrícia

AU - Christie, Celia D C

AU - de Souza, Wayner Vieira

AU - Gotuzzo H, Jose Eduardo

AU - Hoen, Bruno

AU - Koopmans, Marion

AU - Martelli, Celina Maria Turchi

AU - Martins Teixeira, Mauro

AU - Marques, Ernesto T A

AU - Miranda, Maria Consuelo

AU - Montarroyos, Ulisses Ramos

AU - Moreira, Maria Elisabeth

AU - Morris, J Glenn

AU - Rockx, Barry

AU - Saba Villarroel, Paola Mariela

AU - Soria Segarra, Carmen

AU - Tami, Adriana

AU - Turchi, Marília Dalva

AU - Giaquinto, Carlo

AU - de Lamballerie, Xavier

AU - Wilder-Smith, Annelies

AU - Mayaud, Philippe

PY - 2020/12/15

Y1 - 2020/12/15

N2 - INTRODUCTION: Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.METHODS AND ANALYSIS: We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.ETHICS AND DISSEMINATION: Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

AB - INTRODUCTION: Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.METHODS AND ANALYSIS: We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.ETHICS AND DISSEMINATION: Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

U2 - 10.1136/bmjopen-2019-035307

DO - 10.1136/bmjopen-2019-035307

M3 - Article

C2 - 33323426

SN - 2044-6055

VL - 10

JO - BMJ Open

JF - BMJ Open

IS - 12

M1 - e035307

ER -