28th Annual Congress of the European-Association-of-Nuclear-Medicine (EANM)

    Activiteit: Academic presentationAcademic


    Aim: In vivo evaluation of microglia activation and neuroinflammation is considered a potential tool in the management of several neurological and psychiatric disorders. [11C]PK11195 has been widely used for this purpose in PET imaging. However, it possesses a low sensitivity and poor signal-to-noise ratio. For that reason, [11C]CB184 was evaluated as a potential more sensitive PET tracer, using a rat model of herpes encephalitis. Materials and methods: Male Wistar rats were intranasal inoculated with HSV-1 (HSE) or PBS (control). At either day 6 or 7 after inoculation, [11C]CB184 PET scans were acquired, followed by ex vivo biodistribution. Arterial blood sampling of [11C]CB184 and [11C]PK11195 scans was performed for pharmacokinetic modelling. Differences between control and HSE groups were explored using volumes of interest and voxel-based analysis. Results: The ex vivo uptake of [11C]CB184 in HSE rats, as compared with control, was significantly increased (p
    Evenementstitel28th Annual Congress of the European Association of Nuclear Medicine (EANM)
    LocatieHamburg, GermanyToon op kaart