DescriptionMismatch negativity (MMN) is an event related potential (ERP) component in the electroencephalogram (EEG) which represents the pre-attentive process of deviance detection. It can be measured by presenting low-change deviant sensory stimuli randomly distributed in a train of high-change standard stimuli (“oddball” paradigm). MMN is affected in several neuropsychiatric disorders, among which schizophrenia and autism, in line with the sensory deficits observed in these disorders. Neurological disorders like migraine and epilepsy are also related to altered sensory processing, as is the healthy brain during cognitive processing, implying that MMN can have broad functional applications. This study aims to develop a visual MMN paradigm in freely behaving mice to study and intervene with the early developmental processes underlying sensory processing deficits relevant to neuropsychiatric and neurological disorders.
MMN was first discovered and has most abundantly been tested in the auditory domain, but it is important that other sensory domains should not be neglected. Visual MMN has been measured in a number of human studies, but only once before in a rodent study. The mice in this earlier study were head-fixed to ensure that stimuli from a LCD screen reached the mouse eye. To reduce stress and enhance behavioural relevance, we here developed a set-up in which visual MMN can be measured in freely moving mice.
To allow for tethered EEG recordings, mice are implanted with skull electrodes on the visual cortex. Visual stimuli are presented in a LED-illuminated sphere in which mice can move freely. Standard and deviant stimuli are light flashes differing in light intensity. MMN will be assessed from difference waves, which are created by subtraction of average standard from average deviant ERP responses.
First results will be presented on the poster. We hypothesize that mismatch negativity will be observed in freely moving mice in a light-intensity oddball paradigm.
|Evenementstitel||Dutch Neuroscience meeting 2018: null|