Additional file 1 of A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype

  • Sarah Rank Rønnow (Contributor)
  • Jannie Marie Bülow Sand (Contributor)
  • Line Mærsk Staunstrup (Contributor)
  • Thomas Bahmer (Contributor)
  • Michael Wegmann (Contributor)
  • Lars Lunding (Contributor)
  • Janette Burgess (Contributor)
  • Klaus Rabe (Contributor)
  • Grith Lykke Sorensen (Contributor)
  • Oliver Fuchs (Contributor)
  • Erika V. Mutius (Contributor)
  • Gesine Hansen (Contributor)
  • Matthias Volkmar Kopp (Contributor)
  • Morten Karsdal (Contributor)
  • Diana Julie Leeming (Contributor)
  • Markus Weckmann (Contributor)



Additional file 1: Table e1. Basic demographics of the PERF cohort. E-Figure1. A) Correlation betweenserum C1M level and blood neutrophils. Data were analysed using spearman’scorrelation (r = 0.214). B) Patients were stratified into highversus low percentage blood neutrophils levels based on the median. C1M wassignificantly increased in patients with high neutrophil levels (n = 122) compared to low (n = 128) (p = 0.0130). C) C1Mwas significantly increased in obese (BMI>30) patients (n = 60) compared to normal-weight (BMI<25) patients (n = 85) (p < 0.0001). D) Obeseasthmatics with high blood neutrophils (n= 29) had a significant increase in C1M compared to normal-weight asthmaticswith low blood neutrophils (n = 39) (p < 0.0001). Data arepresented as a Tukey box plot and analyzed using the Mann-Whitney test.Asterisks indicate statistically significance: *p < 0.05, ****p < 0.0001.
Datum van beschikbaarheid14-apr.-2022
Uitgeverfigshare Academic Research System
Datum van data-aanmaak13-apr.-2022

Citeer dit