Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

  • Gerrit, L.J. Onderwater (Creator)
  • Lannie Ligthart (Creator)
  • Mariska Bot (Creator)
  • Ayse Demirkan (Creator)
  • Jingyuan Yang-Fu (Creator)
  • Carla J. H. van der Kallen (Creator)
  • Lisanne S Vijfhuizen (Creator)
  • Rene Pool (Creator)
  • Jun Liu (Creator)
  • F. H. M. Vanmolkot (Creator)
  • Marian Beekman (Creator)
  • Ke-xin Wen (Creator)
  • Najaf Amin (Creator)
  • Carisha S Thesing (Creator)
  • Judith A. Pijpers (Creator)
  • Dennis A. Kies (Creator)
  • R Zielman (Creator)
  • Irene Boer, de (Creator)
  • Marleen M. J. van Greevenbroek (Creator)
  • Ilja C W Arts (Creator)
  • Yuri Milaneschi (Creator)
  • Miranda T. Schram (Creator)
  • Pieter C. Dagnelie (Creator)
  • Lude Franke (Contributor)
  • M. Arfan Ikram (Creator)
  • M. D. Ferrari (Creator)
  • Jelle Goeman (Creator)
  • P. Eline Slagboom (Creator)
  • Cisca Wijmenga (Contributor)
  • Coen Da Stehouwer (Creator)
  • Dorret Boomsma (Creator)
  • Cornelia M. van Duijn (Creator)
  • Brenda W. Penninx (Creator)
  • Peter A. C. 't Hoen (Creator)
  • Gisela M. Terwindt (Creator)
  • Arn M. J. M. van den Maagdenberg (Creator)



Objective: To identify a plasma metabolomic biomarker signature for migraine.

Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analyses.

Results: Decreases in the level of apolipoprotein A1 (β −0.10; 95% confidence interval [CI] −0.16, −0.05; adjusted p = 0.029) and free cholesterol to total lipid ratio present in small high-density lipoprotein subspecies (HDL) (β −0.10; 95% CI −0.15, −0.05; adjusted p = 0.029) were associated with migraine status. In addition, only in male participants, a decreased level of omega-3 fatty acids (β −0.24; 95% CI −0.36, −0.12; adjusted p = 0.033) was associated with migraine. Global test analysis further supported that HDL traits (but not other lipoproteins) were associated with migraine status.

Conclusions: Metabolic profiling of plasma yielded alterations in HDL metabolism in migraine patients and decreased omega-3 fatty acids only in male migraineurs.
Datum van beschikbaarheid3-apr.-2019
UitgeverDryad Digital Repository
Geografische dekkingThe Netherlands

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