Supplementary Material for: Urinary Fetuin-A Fragments Predict Progressive eGFR Decline in Two Independent Type 2 Diabetes Cohorts of Different Ethnicities

Introduction There is a great clinical need for novel markers to predict kidney function decline in patients with type 2 diabetes. We explored the potential of post-translationally modified fetuin-A fragments in urine (uPTM-FetA) as such a marker. Methods We included patients with type 2 diabetes from two independent, non-overlapping prospective cohort studies. A cut-off for uPTM-FetA, measured via ELISA method, was determined using the Youden index in the primary cohort of patients with type 2 diabetes from Taiwan. Kidney endpoint was defined as an eGFR decline ≥30% from baseline, reaching of an eGFR