Organisatieprofiel
Organisatieprofiel
Every living organism, from bacteria to plants and humans, is expected to harbor several viruses. These obligate cellular parasites arguably represent one of the most diverse biological entities known to us. Thanks to high-throughput sequencing in the last decade, the number of new viruses discovered has skyrocketed. However, very little is known about these viruses' transmission, evolution, and impact (i.e., their ecology) and how most viruses interact with their host.
Our group focuses on RNA viruses infecting eukaryotes, from unicellular organisms to whales. While we work on a wide range of hosts, we have a special place in our hearts for insects (including mosquitoes). Using an integrated combination of "wet" (experimental evolution, fieldwork, high-throughput sequencing) and "dry" (bioinformatics, phylodynamics, modeling, and simulations) approaches, we explore virus diversity and evolution across scales: from within- to between-hosts, from small transmission chains to epidemics and from deep to recent evolutionary processes.
Because viral evolution takes place at the same time scale as viral ecological processes, our work also uncovers elements of viral ecology: How do they spread? Where do they come from? What is their host range? What is their impact on their hosts? All critical pieces of information to understand and manage their impact on us, our domesticated animals and plants, our ecosystems, and even our biosphere.
Vingerafdruk
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Profielen
-
Anna Haider Rubio
- Faculty of Science and Engineering, De Vos lab - Microbial Eco-Evolutionary Medicine - Promovendus
- Faculty of Science and Engineering, Lequime lab - Virus Ecology and Evolution - Promovendus
Persoon: Wetenschappelijk Personeel
-
Sebastian Lequime
- Faculty of Science and Engineering, Lequime lab - Virus Ecology and Evolution - Universitair docent
Persoon: Wetenschappelijk Personeel
-
Yichen Liu
- Faculty of Science and Engineering, Thieltges lab - Marine Parasite Ecology - Promovendus
- Faculty of Science and Engineering, Lequime lab - Virus Ecology and Evolution - Promovendus
- Faculty of Science and Engineering, Van der Meij lab - Marine Evolutionary Ecology - Promovendus
Persoon: Wetenschappelijk Personeel
-
A missing link in microbial ecology? Unpacking the soil mobilome over a century-long soil chronosequence
Mei, S., jan.-2026, [Groningen]: University of Groningen. 146 blz.Onderzoeksoutput
Open AccessBestand115 Downloads (Pure) -
Characterization and transcriptome analysis of mercury-resistant Pseudomonas canadensis isolated from a chlor-alkali contaminated soil revealed mer-independent detoxification pathways
Meyer, L., Zhou, J., Pfendler, S., Mei, S., Wang, M., Capelli, N., Guyot, S. & Chalot, M., feb.-2026, In: Journal of Hazardous Materials Advances. 21, 15 blz., 101069.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand2 Downloads (Pure) -
Prevalence and distribution of two polycipiviruses in wild black garden ants (Lasius niger L.) in the Netherlands
Manfredonia, I., Chioso, L., Mateescu, I., Konu, M., Brons, J. K., Deelman-Driessen, C., Viljakainen, L., Wertheim, B. & Lequime, S., jul.-2026, In: Journal of invertebrate pathology. 217, 8 blz., 108611.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand
Activiteiten
-
Endogenous viral elements can bias virus discovery
Lequime, S. (Speaker)
1-apr.-2025Activiteit: Academic presentation › Academic
-
Incorporating empirical lab data into epidemiological risk assessments: taking into account host heterogeneity and within-host dynamics
Lequime, S. (Speaker)
21-mrt.-2025Activiteit: Academic presentation › Academic
-
Reconstructing old emergence with archival samples
Lequime, S. (Speaker)
30-okt.-2024Activiteit: Academic presentation › Academic
Datasets
-
-
Chikungunya intra-vector infection dynamics in a French Aedes albopictus population reveals low vector barrier intensity and supports an explosive epidemic potential
Viginier, B. (Creator), Cappuccio, L. (Creator), Garnier, C. (Creator), Martin, E. (Creator), Maisse, C. (Creator), Valiente Moro, C. (Creator), Minard, G. (Creator), Fontaine, A. (Creator), Lequime, S. (Creator), Ratinier, M. (Creator), Arnaud , F. (Creator) & Raquin, V. (Creator), ZENODO, 13-jun.-2023
Dataset
-
Additional file 1 of Long range PCR-based deep sequencing for haplotype determination in mixed HCMV infections
Brait, N. (Contributor), Külekçi, B. (Contributor) & Goerzer, I. (Contributor), figshare, 7-jan.-2022
DOI: 10.6084/m9.figshare.17983013.v1
Dataset
Knipsels
-
Genoom van de gewone strandkrab ontrafeld
Brons, J., Hackl, T., Iacovelli, R., Haslinger, K., Lequime, S. & van der Meij, S.
01/11/2025
1 item van Media-aandacht
Pers / media: Onderzoek › Popular
-
Virussen zijn geniaal, maar er zitten natuurlijk ook bad guys tussen
18/06/2025 → 23/06/2025
4 items van Media-aandacht
Pers / media: Onderzoek › Popular
-
Good practices for FAIR data management
09/04/2025
1 Mediabijdrage
Pers / media: Expert Comment › Professional
projecten
- 2 Afgelopen
-
Can ants be a reservoir of honey bee viruses?
Lequime, S. (Hoofdonderzoeker)
01/04/2023 → 01/04/2024
Project: Research
-
AL-Xtra: Evolutionary interactions between flaviviruses
Lequime, S. (Hoofdonderzoeker), Falcao Salles, J. (Hoofdonderzoeker) & Brait, N. (PhD student)
01/11/2020 → 01/11/2024
Project: Research
Prijzen
-
Open Research Award 2024
Brait, N. (Recipient), Lequime, S. (Recipient) & Hackl, T. (Recipient), 7-nov.-2024
Prijs: Prize › Academic
-
-