Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
Zoekresultaten
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2025
Vvax001, a Therapeutic Vaccine for Patients with HPV16-positive High-grade Cervical Intraepithelial Neoplasia: a Phase II Trial
Eerkens, A. L., Esajas, M. D., Brummel, K., Vledder, A., van Rooij, N., Plat, A., Avalos Haro, S. B., Paijens, S. T., Slagter-Menkema, L., Schuuring, E., Werner, N., Kosterink, J. G. W., Kroesen, B.-J., Wilschut, J. C., Daemen, T., Bart, J., Nijman, H. W., de Bruyn, M. & Yigit, R., 24-jan.-2025, (E-pub ahead of print) In: Clinical Cancer Research.Onderzoeksoutput › Academic › peer review
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2024
B cells critical for outcome in high grade serous ovarian carcinoma
Vledder, A., Paijens, S. T., Loiero, D., Maagdenberg, A., Duiker, E. W., Bart, J., Hendriks, A. M., Jalving, M., Werner, N., van Rooij, N., Plat, A., Wisman, G. B. A., Yigit, R., Roelofsen, T., Kruse, A. J., de Lange, N. M., Koelzer, V. H., de Bruyn, M. & Nijman, H. W., 15-dec.-2024, In: International Journal of Cancer. 155, 12, blz. 2265-2276 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer
Grau Bejar, J. F., Yaniz Galende, E., Zeng, Q., Genestie, C., Rouleau, E., de Bruyn, M., Klein, C., Le Formal, A., Edmond, E., Moreau, M., Plat, A., Gouy, S., Maulard, A., Pautier, P., Michels, J., Oaknin, A., Colomba-Blameble, E. & Leary, A., 1-jul.-2024, In: Journal for immunotherapy of cancer. 12, 7, 15 blz., e009143.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study
Eerkens, A. L., Brummel, K., Vledder, A., Paijens, S. T., Requesens, M., Loiero, D., van Rooij, N., Plat, A., Haan, F.-J., Klok, P., Yigit, R., Roelofsen, T., de Lange, N. M., Klomp, R., Church, D., Ter Elst, A., Wardenaar, R., Spierings, D., Foijer, F. & Koelzer, V. H. & 6 anderen, , dec.-2024, In: Nature Communications. 15, 17 blz., 7695.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2023
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors
Ważyńska, M. A., Butera, R., Requesens, M., Plat, A., Zarganes-Tzitzikas, T., Neochoritis, C. G., Plewka, J., Skalniak, L., Kocik-Krol, J., Musielak, B., Magiera-Mularz, K., Rodriguez, I., Blok, S. N., de Bruyn, M., Nijman, H. W., Elsinga, P. H., Holak, T. A. & Dömling, A., 27-jul.-2023, In: Journal of Medicinal Chemistry. 66, 14, blz. 9577-9591 15 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET
Fan, X., Ważyńska, M. A., Kol, A., Perujo Holland, N., Fernandes, B., van Duijnhoven, S. M. J., Plat, A., van Eenennaam, H., Elsinga, P. H., Nijman, H. W. & de Bruyn, M., 20-nov.-2023, In: EJNMMI Research. 13, 1, 11 blz., 100.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2022
Development of 89 Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
Kol, A., Fan, X., Wazynska, M. A., Van Duijnhoven, S. M. J., Giesen, D., Plat, A., Van Eenennaam, H., Elsinga, P. H., Nijman, H. W. & De Bruyn, M., 5-dec.-2022, In: Journal for immunotherapy of cancer. 10, 12, 32 blz., e004877.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Expression of CD39 Identifies Activated Intratumoral CD8+T Cells in Mismatch Repair Deficient Endometrial Cancer
Lubbers, J. M., Ważyńska, M. A., van Rooij, N., Kol, A., Workel, H. H., Plat, A., Paijens, S. T., Vlaming, M. R., Spierings, D. C. J., Elsinga, P. H., Bremer, E., Nijman, H. W. & de Bruyn, M., 11-apr.-2022, In: Cancers. 14, 8, 13 blz., 1924.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival
Vlaming, M., Bilemjian, V., Freile, J. Á., Melo, V., Plat, A., Huls, G., Nijman, H., de Bruyn, M. & Bremer, E., 21-okt.-2022, In: Frontiers in Immunology. 13, 11 blz., 1031746.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2021
Association of homozygous variants of STING1 with outcome in human cervical cancer
Lubbers, J. M., Koopman, B., de Klerk-Sluis, J. M., van Rooij, N., Plat, A., Pijper, H., Koopman, T., van Hemel, B. M., Hollema, H., Wisman, B., Nijman, H. W. & de Bruyn, M., jan.-2021, In: Cancer science. 112, 1, blz. 61-71 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer
Kol, A., Lubbers, J. M., Terwindt, A. L. J., Workel, H. H., Plat, A., Wisman, G. B. A., Bart, J., Nijman, H. W. & De Bruyn, M., 12-jun.-2021, In: OncoImmunology. 10, 1, 12 blz., 1936391.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients
Paijens, S. T., Vledder, A., Loiero, D., Duiker, E. W., Bart, J., Hendriks, A. M., Jalving, M., Workel, H. H., Hollema, H., Werner, N., Plat, A., Wisman, G. B. A., Yigit, R., Arts, H., Kruse, A. J., de Lange, N. M., Koelzer, V. H., de Bruyn, M. & Nijman, H. W., 6-jun.-2021, In: OncoImmunology. 10, 1, 11 blz., 1935104.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2020
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome
Merkus-Brunekreeft, K., Paijens, S., Wouters, M., Komdeur, F., Eggink, F., Lubbers-Marsman, J., Workel, H., Slikke, van der, E. C., Propper, N. E. J., Leffers, N., Adam, J., Pijper, H., Plat, A., Kol, A., Nijman, H. & Bruyn, de, M., 13-mei-2020, In: OncoImmunology. 9, 1, blz. 1-12 12 blz., 1760705.Onderzoeksoutput › Academic › peer review
Open Access -
Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer
Horeweg, N., de Bruyn, M., Nout, R. A., Stelloo, E., Kedzierska, K. Z., León-Castillo, A., Plat, A., Mertz, K. D., Osse, M., Jürgenliemk-Schulz, I. M., Lutgens, L. C., Jobsen, J. J., van der Steen-Banasik, E. M., Smit, V. T. H. B. M., Creutzberg, C. L., Bosse, T., Nijman, H. W., Koelzer, V. H. & Church, D. N., 1-dec.-2020, In: Cancer immunology research. 8, 12, blz. 1508-1519 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Transcriptional Activity and Stability of CD39+CD103+CD8+T Cells in Human High-Grade Endometrial Cancer
Workel, H. H., van Rooij, N., Plat, A., Spierings, D. C. J., Fehrmann, R. S. N., Nijman, H. W. & de Bruyn, M., jun.-2020, In: International Journal of Molecular Sciences. 21, 11, 18 blz., 3770.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2019
A transcriptionally distinct CXCL13+CD103+CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer
Workel, H. H., Lubbers, J. M., Arnold, R., Prins, T. M., van der Vlies, P., de Lange, K., Bosse, T., Van Gool, I. C., Eggink, F. A., Wouters, M. C., Komdeur, F. L., van der Slikke, E. C., Creutzberg, C. L., Kol, A., Plat, A., Glaire, M., Church, D. N., Nijman, H. W. & de Bruyn, M., mei-2019, In: Cancer immunology research. 7, 5, blz. 784-796 13 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2018
L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition
Versluis, M., Plat, A., de Bruyn, M., Matias-Guiu, X., Trovic, J., Krakstad, C., Nijman, H. W., Bosse, T., de Bock, G. H. & Hollema, H., nov.-2018, In: Virchows Archiv : an International Journal of Pathology. 473, 5, blz. 591-598 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2017
CD103+tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+T cells associated with prognostic benefit and therapy response in cervical cancer
Komdeur, F. L., Prins, T. M., van de Wall, S., Plat, A., Wisman, G. B. A., Hollema, H., Daemen, T., Church, D. N., De Bruyn, M. & Nijman, H. W., 2017, In: OncoImmunology. 6, 9, 14 blz., 1338230.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Mutagenesis of nisin's leader peptide proline strongly modulates export of precursor nisin
Plat, A., Kuipers, A., Crabb, J., Rink, R. & Moll, G. N., mrt.-2017, In: Antonie Van Leeuwenhoek: International Journal of General and Molecular Microbiology. 110, 3, blz. 321-330 10 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment
Versluis, M. A. C., Marchal, S., Plat, A., de Bock, G. H., van Hall, T., de Bruyn, M., Hollema, H. & Nijman, H. W., nov.-2017, In: European Journal of Cancer. 86, blz. 285-295 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
2016
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy
Komdeur, F. L., Wouters, M. C. A., Workel, H. H., Tijans, A. M., Terwindt, A. L. J., Brunekreeft, K. L., Plat, A., Klip, H. G., Eggink, F. A., Leffers, N., Helfrich, W., Samplonius, D. F., Bremer, E., Wisman, G. B. A., Daemen, T., Duiker, E. W., Hollema, H., Nijman, H. W. & de Bruyn, M., 15-nov.-2016, In: Oncotarget. 7, 46, blz. 75130-75144 15 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma
Workel, H. H., Komdeur, F. L., Wouters, M. C. A., Plat, A., Klip, H. G., Eggink, F. A., Wisman, G. B. A., Arts, H. J. G., Oonk, M. H. M., Mourits, M. J. E., Yigit, R., Versluis, M., Duiker, E. W., Hollema, H., de Bruyn, M. & Nijman, H. W., jun.-2016, In: European Journal of Cancer. 60, blz. 1-11 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Discovery, production and modification of 5 novel lantibiotics using the promiscuous nisin modification machinery
van Heel, A. J., Kloosterman, T. G., Montalban-Lopez, M., Deng, J., Plat, A., Baudu, B., Hendriks, D., Moll, G. N. & Kuipers, O. P., 13-jun.-2016, In: ACS Synthetic Biology. 5, 10, blz. 1146-1154 9 blz., 6b00033.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer
Stelloo, E., Versluis, M. A., Nijman, H. W., de Bruyn, M., Plat, A., Osse, E. M., van Dijk, R. H., Nout, R. A., Creutzberg, C. L., de Bock, G. H., Smit, V. T., Bosse, T. & Hollema, H., 28-jun.-2016, In: Oncotarget. 7, 26, blz. 39885-39893 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer
Wouters, M. C. A., Komdeur, F. L., Workel, H. H., Klip, H. G., Plat, A., Kooi, N. M., Wisman, G. B. A., Mourits, M. J. E., Arts, H. J. G., Oonk, M. H. M., Yigit, R., de Jong, S., Melief, C. J. M., Hollema, H., Duiker, E. W., Daemen, T., de Bruyn, M. & Nijman, H. W., 1-feb.-2016, In: Clinical Cancer Research. 22, 3, blz. 714-724 11 blz.Onderzoeksoutput › Academic › peer review
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2015
Prediction model for regional or distant recurrence in endometrial cancer based on classical pathological and immunological parameters
Versluis, M. A., de Jong, R. A., Plat, A., Bosse, T., Smit, V. T., Mackay, H., Powell, M., Leary, A., Mileshkin, L., Kitchener, H. C., Crosbie, E. J., Edmondson, R. J., Creutzberg, C. L., Hollema, H., Daemen, T., de Bock, G. H. & Nijman, H. W., 1-sep.-2015, In: British Jounal of Cancer. 113, 5, blz. 786-793 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy
Wouters, M. C. A., Komdeur, F. L., Workel, H. H., Brunekreeft, K. L., Plat, A., Klip, H. G., Eggink, F. A., Wisman, G. B. A., Arts, H. J. G., Oonk, M. H. M., Mourits, M. J. E., Yigit, R., Versluis, M., Duiker, E. W., Bremer, E., Helfrich, W., Hollema, H., Nijman, H. W. & De Bruyn, M., 2015, In: International journal of molecular medicine. 36, blz. S42-S42 1 blz.Onderzoeksoutput › Academic
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The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide
Baron, W., Ozgen, H., Klunder, B., de Jonge, J. C., Nomden, A., Plat, A., Trifilieff, E., de Vries, H. & Hoekstra, D., jan.-2015, In: Molecular and Cellular Biology. 35, 1, blz. 288-302 15 blz.Onderzoeksoutput › Academic › peer review
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2004
Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype
van Dijk, K., Plat, A., van Dijk, A., Piersma-Wichers, M., de Vries-Bots, A., Slomp, J., de Jong van den Berg, L. & Brouwers, J., jan.-2004, In: Thrombosis and Haemostasis. 91, 1, blz. 95-101 7 blz.Onderzoeksoutput › Academic › peer review