Annet Brouwers-Vos

Zoekresultaten

• 2022

  The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

  Erdem, A., Marin, S., Pereira-Martins, D. A., Cortés, R., Cunningham, A., Pruis, M. G., de Boer, B., van den Heuvel, F. A. J., Geugien, M., Wierenga, A. T. J., Brouwers-Vos, A. Z., Rego, E. M., Huls, G., Cascante, M. & Schuringa, J. J., 1-mrt-2022, In: Nature Communications. 13, 1, 16 blz., 1105.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  4 Downloads (Pure)
• 2021

  The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

  Maat, H., Atsma, T. J., Hogeling, S. M., Lopez, A. R., Jaques, J., Olthuis, M., de Vries, M. P., Gravesteijn, C., Brouwers-Vos, A. Z., van der Meer, N., Datema, S., Salzbrunn, J., Huls, G., Baas, R., Martens, J. H. A., van den Boom, V. & Schuringa, J. J., 21-mei-2021, In: iScience . 24, 5, 29 blz., 102435.

  Onderzoeksoutput › Academic › peer review

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  5 Citaten (Scopus)

  41 Downloads (Pure)
• 2020

  HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate

  Ruckert, M. T., Brouwers-Vos, A. Z., Nagano, L. F. P., Schuringa, J. J. & Silveira, V. S., nov-2020, In: Cancer Gene Therapy. 10-11, blz. 830-833 4 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  2 Citaten (Scopus)

  26 Downloads (Pure)
• 2019

  HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

  Wierenga, A. T. J., Cunningham, A., Erdem, A., Lopera, N. V., Brouwers-Vos, A. Z., Pruis, M., Mulder, A. B., Gunther, U. L., Martens, J. H. A., Vellenga, E. & Schuringa, J. J., 27-dec-2019, In: Cancer & Metabolism. 7, 1, 17 blz., 11.

  Onderzoeksoutput › Academic › peer review

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  75 Downloads (Pure)

• Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells

  Mattes, K., Geugien, M., Korthuis, P. M., Brouwers-Vos, A. Z., Fehrmann, R. S. N., Todorova, T. I., Steidl, U., Vellenga, E. & Schepers, H., mei-2019, In: Experimental Hematology. 73, blz. 38-49 12 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  1 Citaat (Scopus)

  90 Downloads (Pure)
• 2018

  Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones

  de Boer, B., Prick, J., Pruis, M. G., Keane, P., Imperato, M. R., Jaques, J., Brouwers-Vos, A. Z., Hogeling, S. M., Woolthuis, C. M., Nijk, M. T., Diepstra, A., Wandinger, S., Versele, M., Attar, R. M., Cockerill, P. N., Huls, G., Vellenga, E., Mulder, A. B., Bonifer, C. & Schuringa, J. J., 8-okt-2018, In: Cancer cell. 34, 4, blz. 674-+ 24 blz.

  Onderzoeksoutput › Academic › peer review
  42 Citaten (Scopus)
• 2017

  BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells

  Carretta, M., Brouwers-Vos, A. Z., Bosman, M., Horton, S. J., Martens, J. H. A., Vellenga, E. & Schuringa, J. J., 14-dec-2017, In: PLoS ONE. 12, 12, 18 blz., e0189102.

  Onderzoeksoutput › Academic › peer review

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  9 Citaten (Scopus)

  258 Downloads (Pure)
• 2016

  Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches

  Antonelli, A., Noort, W. A., Jaques, J., de Boer, B., de Jong-Korlaar, R., Brouwers-Vos, A. Z., Lubbers-Aalders, L., van Velzen, J. F., Bloem, A. C., Yuan, H., de Bruijn, J. D., Ossenkoppele, G. J., Martens, A. C. M., Vellenga, E., Groen, R. W. J. & Schuringa, J. J., 22-dec-2016, In: Blood. 128, 25, blz. 2949-2959 11 blz.

  Onderzoeksoutput › Academic › peer review
  44 Citaten (Scopus)

• Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation

  Sontakke, P., Koczula, K. M., Jaques, J., Wierenga, A. T. J., Brouwers-Vos, A. Z., Pruis, G., Günther, U. L., Vellenga, E. & Schuringa, J. J., 7-apr-2016, In: PLoS ONE. 11, 4, 16 blz., e0153226.

  Onderzoeksoutput › Academic › peer review

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  13 Citaten (Scopus)

  239 Downloads (Pure)

• Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model

  Sontakke, P., Carretta, M., Jaques, J., Brouwers-Vos, A. Z., Lubbers-Aalders, L., Yuan, H., de Bruijn, J. D., Martens, A. C. M., Vellenga, E., Groen, R. W. J. & Schuringa, J. J., okt-2016, In: Leukemia. 30, 10, blz. 2064-2073 10 blz.

  Onderzoeksoutput › Academic › peer review
  31 Citaten (Scopus)

• Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

  van den Boom, V., Maat, H., Geugien, M., Lopez, A. R., Sotoca, A. M., Jaques, J., Brouwers-Vos, A. Z., Fusetti, F., Groen, R. W. J., Yuan, H., Martens, A. C. M., Stunnenberg, H. G., Vellenga, E., Martens, J. H. A. & Schuringa, J. J., 12-jan-2016, In: Cell reports. 14, 2, blz. 332-346 15 blz.

  Onderzoeksoutput › Academic › peer review

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  81 Citaten (Scopus)

  332 Downloads (Pure)
• 2014

  Aging impairs long-term hematopoietic regeneration after autologous stem cell transplantation

  Woolthuis, C. M., Mariani, N., Verkaik-Schakel, R. N., Brouwers-Vos, A. Z., Schuringa, J. J., Vellenga, E., de Wolf, J. T. M. & Huls, G., jun-2014, In: Biology of Blood and Marrow Transplantation. 20, 6, blz. 865-871 7 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  25 Citaten (Scopus)

  173 Downloads (Pure)

• The TAK1-NF-κB axis as therapeutic target for AML

  Bosman, M. C. J., Schepers, H., Jaques, J., Vos, A., Quax, W. J., Schuringa, J. J. & Vellenga, E., 13-nov-2014, In: Blood. 124, 20, blz. 3130-3140 11 blz.

  Onderzoeksoutput › Academic › peer review
  35 Citaten (Scopus)
• 2013

  Loss of quiescence and impaired function of CD34(+)/CD38(low) cells one year following autologous stem cell transplantation

  Woolthuis, C. M., Brouwers-Vos, A. Z., Huls, G., de Wolf, J. T. M., Schuringa, J. J. & Vellenga, E., dec-2013, In: Haematologica. 98, 12, blz. 1964-1971 8 blz.

  Onderzoeksoutput › Academic › peer review

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  11 Citaten (Scopus)

  184 Downloads (Pure)

• The role of polycomb group proteins in hematopoietic stem cell (HSC) self-renewal and leukemogenesis

  van den Boom, V., Schepers, H., Brouwers-Vos, A. Z. & Schuringa, J., 2013, The role of polycomb group proteins in hematopoietic stem cell (HSC) self-renewal and leukemogenesis. Springer, blz. 142-173 33 blz.

  Onderzoeksoutput: Chapter › Academic

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  572 Downloads (Pure)
• 2011

  Gene expression profiling in the leukemic stem cell-enriched CD34(+) fraction identifies target genes that predict prognosis in normal karyotype AML

  de Jonge, H. J. M., Woolthuis, C. M., Vos, A. Z., Mulder, A., van den Berg, E., Kluin, P. M., van der Weide, K., de Bont, E. S. J. M., Huls, G., Vellenga, E. & Schuringa, J. J., dec-2011, In: Leukemia. 25, 12, blz. 1825-1833 9 blz.

  Onderzoeksoutput › Academic › peer review
  57 Citaten (Scopus)