Keyphrases
Proteolysis Targeting chimera (PROTAC)
86%
Histone Deacetylase 3 (HDAC3)
43%
Macrophages
43%
Anti-inflammatory Potential
43%
M1-like
43%
Hydrazide
43%
HDAC8
43%
Solid Tumors
43%
Hematological Malignancies
43%
Macrophage Polarization
18%
Primary Macrophages
12%
Independent Functions
12%
Deacetylase
12%
Non-enzymatic Function
12%
HDAC Inhibition
12%
Inhibitory Efficacy
8%
Small Molecules
6%
Genetic Depletion
6%
Inflammatory Gene Expression
6%
Anti-migration
6%
Contrast CT
6%
HDAC8 Inhibitor
6%
Micromolar Concentration
6%
Inflammatory Cytokines
6%
Inflammatory Process
6%
Small Molecule Therapeutics
6%
Drug-likeness
6%
Anti-inflammatory Cytokines
6%
THP-1 Cells
6%
Molecular Mechanism
6%
THP1
6%
Anti-inflammatory Activity
6%
Cytokine Secretion
6%
Histone Acetylation
6%
Antiproliferative Activity
6%
Cancer Types
6%
Cancer Cell Lines
6%
Enzymatic Function
6%
Hyperacetylation
6%
Biological Function
6%
Structural Maintenance of Chromosomes Proteins
6%
High Concentration
6%
Immunology and Microbiology
Protein Degradation
100%
Antineoplastic Activity
43%
Catalysis
43%
Antiproliferative Activity
43%
Leukemia Cell
43%
T Cell
43%
Macrophage
43%
Caspase
43%
Cell Death
43%
Biochemistry, Genetics and Molecular Biology
Small Molecule
49%
Protein Catabolism
48%
DNA Repair
43%
Ferroptosis
43%
Antineoplastic Activity
43%
HDAC8
43%
Homologous Recombination
24%
BRCA1 Protein
12%
Cell Death
11%
RAD51
6%
P53
6%
Anticancer
6%
Lipid Peroxidation
6%
DNA Damage
6%
Mitochondrion
6%
Genetics
6%
Catalysis
5%
Antiproliferative Activity
5%
Flow Cytometry
5%
Caspase 3
5%
T Cell
5%
