Cisca Wijmenga

2025

High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation

Slager, J., Simpson, H. L., Gacesa, R., Chen, L., Tan, I. L., Gelderloos, J., Maatman, A., Wijmenga, C., Zhernakova, A., Fu, J., Weersma, R. K., Gonera, G., Jonkers, I. H. & Withoff, S., 2025, In: Gut Microbes. 17, 1, 24 blz., 2489071.

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1 Citaat (Scopus)

2 Downloads (Pure)

Human organoids and organ-on-chips in coeliac disease research

Simpson, H. L., Smits, E., Moerkens, R., Wijmenga, C., Mooiweer, J., Jonkers, I. H. & Withoff, S., feb.-2025, In: Trends in Molecular Medicine. 31, 2, blz. 117-137 21 blz.

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1 Citaat (Scopus)

46 Downloads (Pure)

2024

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells

Moerkens, R., Mooiweer, J., Ramírez-Sánchez, A. D., Oelen, R., Franke, L., Wijmenga, C., Barrett, R. J., Jonkers, I. H. & Withoff, S., 23-jul.-2024, In: Cell reports. 43, 7, 26 blz., 114247.

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19 Citaten (Scopus)

1442 Downloads (Pure)

Author Correction: Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines (Scientific Reports, (2023), 13, 1, (11713), 10.1038/s41598-023-38223-5)

Lifelines Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A., Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H., Burtin, C. & Janssen, D. J. A., dec.-2024, In: Scientific Reports. 14, 8390.

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Open Access

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses

Fernández-Pato, A., Sinha, T., Gacesa, R., Andreu-Sánchez, S., Gois, M. F. B., Gelderloos-Arends, J., Jansen, D. B. H., Kruk, M., Jaeger, M., Joosten, L. A. B., Netea, M. G., Weersma, R. K., Wijmenga, C., Harmsen, H. J. M., Fu, J., Zhernakova, A. & Kurilshikov, A., 16-feb.-2024, In: Scientific Reports. 14, 11 blz., 3911.

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12 Citaten (Scopus)

122 Downloads (Pure)

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

International Multiple Sclerosis Genetics Consortium, Lincoln, M. R., Connally, N., Axisa, P.-P., Gasperi, C., Mitrovic, M., van Heel, D., Wijmenga, C., Withoff, S., Jonkers, I. H., Padyukov, L., Rich, S. S., Graham, R. R., Gaffney, P. M., Langefeld, C. D., Vyse, T. J., Hafler, D. A., Chun, S., Sunyaev, S. R. & Cotsapas, C., mei-2024, In: Nature genetics. 56, 5, blz. 838-845 8 blz.

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8 Citaten (Scopus)

85 Downloads (Pure)

High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation

Slager, J., Simpson, H. L., Gacesa, R., Chen, L., Tan, I. L., Gelderloos, J., Maatman, A., Wijmenga, C., Zhernakova, A., Fu, J., Weersma, R. K., Gonera, G., Jonkers, I. H. & Withoff, S., 21-dec.-2024, BioRxiv.

Onderzoeksoutput: Voordruk › Academic

Open Access

Host genetic regulation of human gut microbial structural variation

Lifelines Cohort Study, Zhernakova, D. V., Wang, D., Liu, L., Andreu-Sánchez, S., Zhang, Y., Ruiz-Moreno, A. J., Peng, H., Plomp, N., Del Castillo-Izquierdo, Á., Gacesa, R., Lopera-Maya, E. A., Temba, G. S., Kullaya, V. I., van Leeuwen, S. S., Xavier, R. J., de Mast, Q., Joosten, L. A. B., Riksen, N. P. & Rutten, J. H. W. & 7 anderen, Netea, M. G., Sanna, S., Wijmenga, C., Weersma, R. K., Zhernakova, A., Harmsen, H. J. M. & Fu, J., 25-jan.-2024, In: Nature. 625, blz. 813–821 9 blz.

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63 Citaten (Scopus)

681 Downloads (Pure)

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

Moerkens, R., Mooiweer, J., Smits, E., Berg, M., Ramírez-Sánchez, A. D., Modderman, R., Puschhof, J., Pleguezuelos-Manzano, C., Barrett, R. J., Wijmenga, C., Jonkers, I. H. & Withoff, S., 1-jul.-2024, BioRxiv.

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Open Access

Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study

Demirkan, A., van Dongen, J., Finnicum, C. T., Westra, H. J., Jankipersadsing, S., Willemsen, G., Ijzerman, R. G., Boomsma, D. I., Ehli, E. A., Bonder, M. J., Fu, J., Franke, L., Wijmenga, C., de Geus, E. J. C., Kurilshikov, A. & Zhernakova, A., dec.-2024, In: BMC Genomics. 25, 11 blz., 1224.

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NMR metabolomics-guided DNA methylation mortality predictors

BBMRI Consortium, Bizzarri, D., Reinders, M. J. T., Kuiper, L., Beekman, M., Deelen, J., van Meurs, J. B. J., van Dongen, J., Pool, R., Boomsma, D. I., Ghanbari, M. & Franke, L., sep.-2024, In: EBioMedicine. 107, 17 blz., 105279.

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3 Citaten (Scopus)

77 Downloads (Pure)

Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data

Bios Consortium , van Hilten, A., van Rooij, J., Ikram, M. A., Niessen, W. J., van Meurs, J. B. J. & Roshchupkin, G. V., dec.-2024, In: npj Systems Biology and Applications. 10, 10 blz., 81.

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6 Citaten (Scopus)

69 Downloads (Pure)

Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing

Tan, I. L., Modderman, R., Stachurska, A., Almeida, R., de Vries, R., Heersema, D. J., Gacesa, R., Wijmenga, C., Jonkers, I. H., Meilof, J. F. & Withoff, S., 2024, In: Brain Communications. 6, 4, 18 blz., fcae209.

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2 Citaten (Scopus)

65 Downloads (Pure)

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Lifelines NEXT cohort study, Garmaeva, S., Sinha, T., Gulyaeva, A., Kuzub, N., Spreckels, J. E., Andreu-Sánchez, S., Gacesa, R., Vich Vila, A., Brushett, S., Kruk, M., Dekens, J., Sikkema, J., Kuipers, F., Shkoporov, A. N., Hill, C., Scherjon, S., Wijmenga, C., Fu, J. & Kurilshikov, A. & 1 anderen, Zhernakova, A., 2-mrt.-2024, In: Nature Communications. 15, 1, 19 blz., 1945.

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13 Citaten (Scopus)

129 Downloads (Pure)

2023

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

BBJ, BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation Scotland, Genes & Health, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, UKBB & Wang, Y. & 22 anderen, Namba, S., Lopera, E., Tsuo, K., Läll, K., Kanai, M., Zhou, W., Wu, K. H. H., Favé, M. J., Bhatta, L., Awadalla, P., Brumpton, B., Deelen, P., Hveem, K., Lo Faro, V., Mägi, R., Murakami, Y., Sanna, S., Smoller, J. W., Uzunovic, J., Wolford, B. N., Martin, A. R. & Hirbo, J. B., 11-jan.-2023, In: Cell Genomics. 3, 1, 18 blz., 100241.

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58 Citaten (Scopus)

206 Downloads (Pure)

Gut feelings: the relations between depression, anxiety, psychotropic drugs and the gut microbiome

Brushett, S., Gacesa, R., Vila, A. V., Gois, M. F. B., Andreu-Sánchez, S., Swarte, J. C., Klaassen, M. A. Y., Collij, V., Sinha, T., Bolte, L. A., Wu, J., Swertz, M., Kroon, M. L. A. D., Reijneveld, S. A., Wijmenga, C., Weersma, R. K., Fu, J., Loo, H. M. V., Kurilshikov, A. & Zhernakova, A., 18-dec.-2023, In: Gut Microbes. 15, 2, 14 blz., 2281360.

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14 Citaten (Scopus)

122 Downloads (Pure)

HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44⁺ Natural Killer Cells in Ulcerative Colitis

Hamburg Intestinal Tissue Study Group, International Inflammatory Bowel Disease Genetics Consortium, Baumdick, M. E., Niehrs, A., Degenhardt, F., Schwerk, M., Hinrichs, O., Jordan-Paiz, A., Padoan, B., Wegner, L. H. M., Schloer, S., Zecher, B. F., Malsy, J., Joshi, V. R., Illig, C., Schröder-Schwarz, J., Möller, K. J., Martin, M. P., Yuki, Y. & Ozawa, M. & 12 anderen, Sauter, J., Schmidt, A. H., Perez, D., Giannou, A. D., Carrington, M., Davis, R. S., Schumacher, U., Sauter, G., Huber, S., Puelles, V. G., Melling, N. & Franke, A., okt.-2023, In: Gastroenterology. 165, 4, blz. 946-962.e13 30 blz.

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12 Citaten (Scopus)

88 Downloads (Pure)

Impact of occupational pesticide exposure on the human gut microbiome

Gois, M. F. B., Fernández-Pato, A., Huss, A., Gacesa, R., Wijmenga, C., Weersma, R. K., Fu, J., Vermeulen, R. C. H., Zhernakova, A., Lenters, V. C. & Kurilshikov, A., 10-aug.-2023, In: Frontiers in Microbiology. 14, 11 blz., 1223120.

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12 Citaten (Scopus)

106 Downloads (Pure)

Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity

TANDEM Consortium$, Eckold, C., van Doorn, C. L. R., Ruslami, R., Ronacher, K., Riza, A.-L., van Veen, S., Lee, J.-S., Kumar, V., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K., Joosten, S. A., Critchley, J. A., Hill, P. C., van Crevel, R., Wijmenga, C., Haks, M. C. & Ioana, M. & 6 anderen, Alisjahbana, B., Walzl, G., Ottenhoff, T. H. M., Dockrell, H. M., Vianello, E. & Cliff, J. M., sep.-2023, In: Clinical and Translational Medicine. 13, 9, 21 blz., e1375.

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iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies

Palasantzas, V. E. J. M., Tamargo-Rubio, I., Le, K., Slager, J., Wijmenga, C., Jonkers, I. H., Kumar, V., Fu, J. & Withoff, S., apr.-2023, In: Trends in Genetics. 39, 4, blz. 268-284 17 blz.

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50 Citaten (Scopus)

198 Downloads (Pure)

Ons microbioom: een afspiegeling van ons dagelijks leven

Wijmenga, C., 5-apr.-2023

Onderzoeksoutput: Other contribution › Popular

Open Access

OTTERS: a powerful TWAS framework leveraging summary-level reference data

eQTLgen Consortium, Dai, Q., Zhou, G., Zhao, H., Võsa, U., Franke, L., Battle, A., Teumer, A., Lehtimäki, T., Raitakari, O. T., Esko, T., Epstein, M. P. & Yang, J., dec.-2023, In: Nature Communications. 14, 13 blz., 1271.

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22 Citaten (Scopus)

197 Downloads (Pure)

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Bourgonje, A. R., Andreu-Sánchez, S., Vogl, T., Hu, S., Vich Vila, A., Gacesa, R., Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka, I. N., van Dullemen, H. M., Weinberger, A., Visschedijk, M. C., Festen, E. A. M., Faber, K. N., Wijmenga, C., Dijkstra, G., Segal, E., Fu, J. & Zhernakova, A. & 1 anderen, Weersma, R. K., 13-jun.-2023, In: Immunity. 56, 6, blz. 1393-1409.e6 23 blz.

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31 Citaten (Scopus)

353 Downloads (Pure)

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire

Lifelines Cohort Study, Andreu-Sánchez, S., Bourgonje, A. R., Vogl, T., Kurilshchikov, A., Leviatan, S., Ruiz-Moreno, A. J., Hu, S., Sinha, T., Vich Vila, A., Klompus, S., Kalka, I. N., de Leeuw, K., Arends, S., Jonkers, I., Withoff, S., Brouwer, E., Weinberger, A., Wijmenga, C. & Segal, E. & 3 anderen, Weersma, R. K., Fu, J. & Zhernakova, A., 13-jun.-2023, In: Immunity. 56, 6, blz. 1376-1392.e8 26 blz.

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19 Citaten (Scopus)

326 Downloads (Pure)

Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers

The Netherlands A. C. M./P. L. N. Registry, Lifelines Cohort Study, Lopera-Maya, E. A., Li, S., de Brouwer, R., Nolte, I. M., van Breen, J., Jongbloed, J. D. H., Swertz, M. A., Snieder, H., Franke, L., Wijmenga, C., de Boer, R. A., Deelen, P., van der Zwaag, P. A. & Sanna, S., dec.-2023, In: Journal of cardiovascular translational research. 16, blz. 1251–1266 16 blz.

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3 Citaten (Scopus)

70 Downloads (Pure)

Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines

Lifelines Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A., Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H., Burtin, C. & Janssen, D. J. A., dec.-2023, In: Scientific Reports. 13, 9 blz., 11713.

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4 Citaten (Scopus)

119 Downloads (Pure)

Workplace impact on employees: A Lifelines Corona Research Initiative on the return to work

Lifelines Corona Research initiative, Mobach, M. P., Boezen, H. M., Mierau, J. O., Franke, H. L., Dekens, J., Deelen, P., Lanting, P., Vonk, J. M., Nolte, I., Ori, A. P. S., Claringbould, A., Boulogne, F., Dijkema, M. X. L., Wiersma, H. H., Warmerdam, R., Jankipersadsing, S. A., van Blokland, I., de Bock, G. T. H. & Rosmalen, J. G. M. & 1 anderen, Wijmenga, C., 5-jan.-2023, In: PLoS ONE. 18, 1, 19 blz., e0279902.

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3 Citaten (Scopus)

117 Downloads (Pure)

2022

A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Chu, X., Janssen, A. W. M., Koenen, H., Chang, L., He, X., Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga, C., Xu, C.-J., Netea, M. G., Tack, C. J., Li, Y. & Buettner, C., 31-mei-2022, In: eLife. 11, 17 blz., 73709.

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6 Citaten (Scopus)

72 Downloads (Pure)

An integrative genomics approach identifies KDM4 as a modulator of trained immunity

Moorlag, S. J. C. F. M., Matzaraki, V., van Puffelen Heijden, J. H., van der Heijden, C., Keating, S., Groh, L., Bakker, O. B., Koeken, V. A. C. M., de Bree, L. C. J., Smeekens, S. P., Oosting, M., Gamboa, R. A., Riksen, N. P., Xavier, R. J., Wijmenga, C., Kumar, V., van Crevel, R., Novakovic, B., Joosten, L. A. B. & Li, Y. & 1 anderen, Netea, M. G., mrt.-2022, In: European Journal of Immunology. 52, 3, blz. 431-446 16 blz.

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37 Citaten (Scopus)

192 Downloads (Pure)

Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project (Nature Genetics, (2022), 54, 2, (143-151), 10.1038/s41588-021-00992-y)

Lifelines Cohort Study, Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Andreu-Sánchez, S., Chen, L., Vila, A. V., Gacesa, R., Sinha, T., Collij, V., Klaassen, M. A. Y., Bolte, L. A., Gois, M. F. B., Neerincx, P. B. T., Swertz, M. A., Harmsen, H. J. M., Wijmenga, C., Fu, J. & Weersma, R. K. & 2 anderen, Zhernakova, A. & Sanna, S., 1-sep.-2022, In: Nature genetics. 54, 9, blz. 1448 1 blz.

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7 Citaten (Scopus)

Discovery, diversity, and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts

Gulyaeva, A., Garmaeva, S., Ruigrok, R. A. A. A., Wang, D., Riksen, N. P., Netea, M. G., Wijmenga, C., Weersma, R. K., Fu, J., Vila, A. V., Kurilshikov, A. & Zhernakova, A., 11-jan.-2022, In: Cell reports. 38, 2, 21 blz., 110204.

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36 Citaten (Scopus)

186 Downloads (Pure)

DNA methylation in peripheral tissues and left-handedness

BIOS Consortium, Odintsova, V. V., Suderman, M., Hagenbeek, F. A., Caramaschi, D., Hottenga, J. J., Pool, R., Dolan, C. V., Ligthart, L., van Beijsterveldt, C. E. M., Willemsen, G., de Geus, E. J. C., Beck, J. J., Ehli, E. A., Cuellar-Partida, G., Evans, D. M., Medland, S. E., Relton, C. L., Boomsma, D. I. & van Dongen, J., dec.-2022, In: Scientific Reports. 12, 16 blz., 5606.

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15 Citaten (Scopus)

3 Downloads (Pure)

Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

Lifelines Cohort Study, Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Andreu-Sánchez, S., Chen, L., Vich-Vila, A., Gacesa, R., Sinha, T., Collij, V., Klassen, M. A. Y., Bolte, L. A., Brandao-Gois, M. F., Neerincx, P. B. T., Swertz, M. A., Harmsen, H. J. M., Wijmenga, C., Fu, J. & Weersma, R. K. & 2 anderen, Zhernakova, A. & Sanna, S., apr.-2022, In: European Journal of Human Genetics. 30, SUPPL 1, blz. 589-589 1 blz.

Onderzoeksoutput › Academic

Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Lifelines Cohort Study, Andreu-Sánchez, S., Chen, L., Vila, A. V., Gacesa, R., Sinha, T., Collij, V., Klaassen, M. A. Y., Bolte, L. A., Brandao Gois, M. F., Neerincx, P. B. T., Swertz, M. A., Harmsen, H. J. M., Wijmenga, C., Fu, J. & Weersma, R. K. & 2 anderen, Zhernakova, A. & Sanna, S., feb.-2022, In: Nature genetics. 54, blz. 143-151 9 blz.

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273 Citaten (Scopus)

1573 Downloads (Pure)

Environmental factors shaping the gut microbiome in a Dutch population

Gacesa, R., Kurilshikov, A., Vich Vila, A., Sinha, T., Klaassen, M. A. Y., Bolte, L. A., Andreu-Sánchez, S., Chen, L., Collij, V., Hu, S., Dekens, J. A. M., Lenters, V. C., Björk, J. R., Swarte, J. C., Swertz, M. A., Jansen, B. H., Gelderloos-Arends, J., Jankipersadsing, S., Hofker, M. & Vermeulen, R. C. H. & 6 anderen, Sanna, S., Harmsen, H. J. M., Wijmenga, C., Fu, J., Zhernakova, A. & Weersma, R. K., 2022, In: Nature. blz. 732–739 25 blz.

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422 Citaten (Scopus)

3329 Downloads (Pure)

Genetic, parental and lifestyle factors influence telomere length

Andreu-Sánchez, S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S., Zhernakova, D. V., Sinha, T., Kurilshikov, A., Cenit, M. C., Jan Bonder, M., Franke, L., Wijmenga, C., Fu, J., van der Wijst, M. G. P., Melé, M., Lansdorp, P. & Zhernakova, A., 9-jun.-2022, In: Communications biology. 5, 1, 13 blz., 565.

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42 Citaten (Scopus)

144 Downloads (Pure)

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

BIOS Consortium, Brain MEND Consortium, Hop, P. J., Zwamborn, R. A. J., Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H. J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al Khleifat, A., Iacoangeli, A., Ticozzi, N. & Ratti, A. & 25 anderen, Cooper-Knock, J., Morrison, K. E., Shaw, P. J., Basak, A. N., Chiò, A., Calvo, A., Moglia, C., Canosa, A., Brunetti, M., Grassano, M., Gotkine, M., Lerner, Y., Zabari, M., Vourc'H, P., Corcia, P., Couratier, P., Mora Pardina, J. S., Salas, T., Dion, P., Ross, J. P., Henderson, R. D., Mathers, S., McCombe, P. A., Needham, M. & Veldink, J. H., 23-feb.-2022, In: Science Translational Medicine. 14, 633, 16 blz., eabj0264.

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61 Citaten (Scopus)

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Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, Biobank of the Americas, BioBank Japan Project & BioMe & 54 anderen, BioVU, CanPath - Ontario Health Study, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, Zhou, W., Kanai, M., Wu, K. H. H., Rasheed, H., Tsuo, K., Hirbo, J. B., Wang, Y., Bhattacharya, A., Zhao, H., Namba, S., Surakka, I., Wolford, B. N., Lo Faro, V., Lopera-Maya, E. A., Läll, K., Favé, M. J., Partanen, J. J., Chapman, S. B., Karjalainen, J., Kurki, M., Maasha, M., Brumpton, B. M., Chavan, S., Chen, T. T., Daya, M., Ding, Y., Feng, Y. C. A., Guare, L. A., Gignoux, C. R., Graham, S. E., Hornsby, W. E., Ingold, N., Ismail, S. I., Johnson, R., Laisk, T., Lin, K., Lv, J., Millwood, I. Y., Moreno-Grau, S., Nam, K., Palta, P., Pandit, A., de Bock, G. H., Jansonius, N. M., Boezen, M., Franke, L., Snieder, H., Vonk, J. M., Wijmenga, C. & Sanna, S., 12-okt.-2022, In: Cell Genomics. 2, 10, 15 blz., 100192.

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Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation

Swarte, J. C., Li, Y., Hu, S., Björk, J. R., Gacesa, R., Vich Vila, A., Douwes, R. M., Collij, V., Kurilshikov, A., Post, A., Klaassen, M. A. Y., Eisenga, M. F., Gomes-Neto, A. W., Kremer, D., Jansen, B. H., Knobbe, T. J., Berger, S. P., Sanders, J.-S. F., Heiner-Fokkema, M. R. & Porte, R. J. & 10 anderen, Cuperus, F. J. C., de Meijer, V. E., Wijmenga, C., Festen, E. A. M., Zhernakova, A., Fu, J., Harmsen, H. J. M., Blokzijl, H., Bakker, S. J. L. & Weersma, R. K., 31-aug.-2022, In: Science Translational Medicine. 14, 660, 15 blz., eabn7566.

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In-depth characterisation of the serum antibody epitope repertoire in Inflammatory Bowel Disease by high-throughput phage-displayed immunoprecipitation sequencing

Bourgonje, A. R., Andreu-Sánchez, S., Vogl, T., Hu, S., Vich Vila, A., Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka, I. N., van Dullemen, H. M., Weinberger, A., Visschedijk, M. C., Festen, E. A. M., Faber, K. N., Wijmenga, C., Dijkstra, G., Segal, E., Fu, J., Zhernakova, A. & Weersma, R. K., 21-jan.-2022, In: Journal of Crohn's and Colitis. 16, Suppl(1), blz. S100-S102 3 blz.

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Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Lifelines Cohort Study, Chen, L., Zhernakova, D. V., Kurilshikov, A., Andreu-Sánchez, S., Wang, D., Augustijn, H. E., Vich Vila, A., Weersma, R. K., Medema, M. H., Netea, M. G., Kuipers, F., Wijmenga, C., Zhernakova, A. & Fu, J., nov.-2022, In: Nature Medicine. 28, blz. 2333–2343 24 blz.

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Integrated fecal microbiome–metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome

Mujagic, Z., Kasapi, M., Jonkers, D. M. A. E., Garcia-Perez, I., Vork, L., Weerts, Z. Z. R. M., Serrano-Contreras, J. I., Zhernakova, A., Kurilshikov, A., Scotcher, J., Holmes, E., Wijmenga, C., Keszthelyi, D., Nicholson, J. K., Posma, J. M. & Masclee, A. A. M., 2022, In: Gut Microbes. 14, 1, 19 blz., 2063016.

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Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

Global Biobank Meta-analysis Initiative, Kanai, M., Elzur, R., Zhou, W., Daly, M. J. & Finucane, H. K., 14-dec.-2022, In: Cell Genomics. 2, 12, 22 blz., 100210.

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Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations

Estonian Biobank Research Team, Lepamets, M., Auwerx, C., Nõukas, M., Claringbould, A., Porcu, E., Kals, M., Jürgenson, T., Morris, A. P., Võsa, U., Bochud, M., Stringhini, S., Wijmenga, C., Franke, L., Peterson, H., Vilo, J., Lepik, K., Mägi, R. & Kutalik, Z., 13-okt.-2022, In: Human Genetics and Genomics Advances. 3, 4, 12 blz., 100133.

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Role of the gut microbiome in mediating lactose intolerance symptoms

Brandao Gois, M. F., Sinha, T., Spreckels, J. E., Vich Vila, A., Bolte, L. A., Weersma, R. K., Wijmenga, C., Fu, J., Zhernakova, A. & Kurilshikov, A., 1-jan.-2022, In: Gut. 71, 1, blz. 215-217 2 blz.

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Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

Ramírez-Sánchez, A. D., Chu, X., Modderman, R., Kooy-Winkelaar, Y., Koletzko, S., Korponay-Szabó, I. R., Troncone, R., Wijmenga, C., Mearin, L., Withoff, S., Jonkers, I. H. & Li, Y., 15-mrt.-2022, In: Frontiers in Immunology. 13, 14 blz., 843086.

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Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

Doestzada, M., Zhernakova, D. V., C L van den Munckhof, I., Wang, D., Kurilshikov, A., Chen, L., Bloks, V. W., van Faassen, M., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G., Wijmenga, C., Riksen, N. P., Zhernakova, A., Kuipers, F. & Fu, J., 15-dec.-2022, In: BMC Medicine. 20, 1, 15 blz., 485.

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Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment

TANDEM Consortium, van Doorn, C. L. R., Eckold, C., Ronacher, K., Ruslami, R., van Veen, S., Lee, J.-S., Kumar, V., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K., Hill, P. C., Joosten, S. A., van Crevel, R., Wijmenga, C., Critchley, J. A., Walzl, G., Alisjahbana, B. & Haks, M. C. & 4 anderen, Dockrell, H. M., Ottenhoff, T. H. M., Vianello, E. & Cliff, J. M., aug.-2022, In: EBioMedicine. 82, 17 blz., 104173.

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