Dirk Slotboom

Zoekresultaten

• 2022

  A conserved sequence motif in the E. coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency

  Partipilo, M., Yang, G., Mascotti, L., Slotboom, D. & Fraaije, M., sep.-2022, In: The Journal of Biological Chemistry. 298, 9, 13 blz., 102304.

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  8 Downloads (Pure)

• Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance

  Walter, J. D., Scherer, M., Hutter, C. A. J., Garaeva, A. A., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J. C., Egloff, P., Sorgenfrei, M., Hürlimann, L. M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., van Geest, G., Bruggmann, R., Zimmer, G., Slotboom, D. J., & 3 anderenPaulino, C., Plattet, P. & Seeger, M. A., 5-apr.-2022, In: Embo Reports. 23, 4, 19 blz., e54199.

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  7 Citaten (Scopus)

  21 Downloads (Pure)

• Correction to: On the Role of a Conserved Methionine in the Na+-Coupling Mechanism of a Neurotransmitter Transporter Homolog (Neurochemical Research, (2022), 47, 1, (163-175), 10.1007/s11064-021-03253-w)

  Zhou, W., Trinco, G., Slotboom, D. J., Forrest, L. R. & Faraldo-Gómez, J. D., jan.-2022, In: NEUROCHEMICAL RESEARCH. 47, 1, blz. 176 1 blz.

  Onderzoeksoutput: Erratum

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  3 Downloads (Pure)

• High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS

  Maity, S., Trinco, G., Buzón, P., Anshari, Z. R., Kodera, N., Ngo, K. X., Ando, T., Slotboom, D. J. & Roos, W. H., 8-feb.-2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 6, 9 blz., e2113927119.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  1 Citaat (Scopus)

  47 Downloads (Pure)

• Membrane transport of cobalamin

  Nijland, M., Martínez Felices, J. M., Slotboom, D. J. & Thangaratnarajah, C., 22-mrt.-2022, Vitamins and Hormones. Litwack, G. (redactie). ACADEMIC PRESS INC ELSEVIER SCIENCE, blz. 121-148 28 blz. (Vitamins and Hormones; vol. 119).

  Onderzoeksoutput › Academic › peer review
  2 Citaten (Scopus)

• On the Role of a Conserved Methionine in the Na+-Coupling Mechanism of a Neurotransmitter Transporter Homolog

  Zhou, W., Trinco, G., Slotboom, D. J., Forrest, L. R. & Faraldo-Gómez, J. D., jan.-2022, In: NEUROCHEMICAL RESEARCH. 47, 1, blz. 163-175 13 blz.

  Onderzoeksoutput › Academic › peer review

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  1 Citaat (Scopus)

  10 Downloads (Pure)
• 2021

  Iminoboronates as Dual-Purpose Linkers in Chemical Probe Development

  van der Zouwen, A. J. N., Jeucken, A., Steneker, R., Hohmann, K. F., Lohse, J., Slotboom, D. J. & Witte, M., 15-feb.-2021, In: Chemistry. 27, 10, blz. 3292-3296 5 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  4 Citaten (Scopus)

  39 Downloads (Pure)

• Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM

  Thangaratnarajah, C., Rheinberger, J., Paulino, C. & Slotboom, D. J., 24-aug.-2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 34, 9 blz., e2105014118.

  Onderzoeksoutput › Academic › peer review

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  2 Citaten (Scopus)

  122 Downloads (Pure)

• Kinetic mechanism of Na+-coupled aspartate transport catalyzed by GltTk

  Trinco, G., Arkhipova, V., Garaeva, A., Hutter, C. A. J., Seeger, M. A., Guskov, A. & Slotboom, D., 17-jun.-2021, In: Communications biology. 4, 11 blz., 751.

  Onderzoeksoutput › Academic › peer review

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  4 Citaten (Scopus)

  28 Downloads (Pure)

• Minimal Pathway for the Regeneration of Redox Cofactors

  Partipilo, M., Ewins, E. J., Frallicciardi, J., Robinson, T., Poolman, B. & Slotboom, D. J., 27-dec.-2021, In: JACS Au. 1, 12, blz. 2280-2293 14 blz.

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  43 Downloads (Pure)

• Rational design of ASCT2 inhibitors using an integrated experimental-computational approach

  Garibsingh, R-A. A., Ndaru, E., Garaeva, A. A., Shi, Y., Zielewicz, L., Zakrepine, P., Bonomi, M., Slotboom, D. J., Paulino, C., Grewer, C. & Schlessinger, A., 14-sep.-2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, 10 blz., e2104093118.

  Onderzoeksoutput › Academic › peer review

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  15 Citaten (Scopus)

  23 Downloads (Pure)

• Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue

  Arkhipova, V., Fu, H., Hoorens, M., Trinco, G., Lameijer, L., Marin, E., Feringa, B. L., Poelarends, G., Szymanski, W., Slotboom, D. & Guskov, A., mrt.-2021, In: Journal of the American Chemical Society. 143, 3, blz. 1513-1520 8 blz.

  Onderzoeksoutput › Academic › peer review

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  15 Citaten (Scopus)

  92 Downloads (Pure)
• 2020

  A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds

  Rempel, S., Gati, C., Nijland, M., Thangaratnarajah, C., Karyolaimos, A., Gier, J-W. L. D., Guskov, A. & Slotboom, D., 16-apr.-2020, In: Nature. 580, 7803, blz. 409-412 4 blz.

  Onderzoeksoutput › Academic › peer review

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  47 Citaten (Scopus)

  74 Downloads (Pure)

• An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

  Jochim, A., Adolf, L., Belikova, D., Schilling, N. A., Setyawati, I., Chin, D., Meyers, S., Verhamme, P., Heinrichs, D. E., Slotboom, D. J. & Heilbronner, S., jun.-2020, In: eLife. 9, 20 blz., e57322.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  11 Citaten (Scopus)

  73 Downloads (Pure)

• Bacterial multi-solute transporters

  Slotboom, D. J., Ettema, T. W., Nijland, M. & Thangaratnarajah, C., dec.-2020, In: FEBS Letters. 594, 23, blz. 3898-3907 10 blz.

  Onderzoeksoutput › peer review

  Open Access

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  6 Citaten (Scopus)

  53 Downloads (Pure)

• Elevator-type mechanisms of membrane transport

  Garaeva, A. A. & Slotboom, D. J., jun.-2020, In: Biochemical Society Transactions. 48, 3, blz. 1227-1241 15 blz., BST20200290.

  Onderzoeksoutput › peer review

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  33 Citaten (Scopus)

  86 Downloads (Pure)

• Highly potent bispecific sybodies neutralize SARS-CoV-2

  Walter, J. D., Hutter, C. A., Garaeva, A. A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J. C., Egloff, P., Sorgenfrei, M., Hürlimann, L. M., Gonda, I., Meier, G., Remme, S., Thavarasah, S., van der Geest, G., Bruggman, R., Zimmer, G., Slotboom, D., & 3 anderenPaulino, C., Plattet, P. & Seeger, M. A., nov.-2020, BioRxiv.

  Onderzoeksoutput: Working paper › Academic

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  78 Downloads (Pure)

• In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters

  Setyawati, I., Stanek, W. K., Dosz-Majsnerowska, M., Ziel-Swier, L., Pardon, E., Steyaert, J., Guskov, A. & Slotboom, D., 22-dec.-2020, In: eLife. 9, blz. 1-21 21 blz., e64389.

  Onderzoeksoutput › Academic › peer review

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  9 Citaten (Scopus)

  43 Downloads (Pure)

• Membrane mediated toppling mechanism of the folate energy coupling factor transporter

  Faustino, I., Abdizadeh, H., Souza, P. C. T., Jeucken, A., Stanek, W. K., Guskov, A., Slotboom, D. & Marrink, S., 1-dec.-2020, In: Nature Communications. 11, 1, 10 blz., 1763.

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  13 Citaten (Scopus)

  103 Downloads (Pure)

• Molecular insight into a new low affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis

  Leth, M. L., Ejby, M., Madland, E., Kitaoku, Y., Slotboom, D. J., Guskov, A., Aachmann, F. L. & Abou Hachem, M., 1-mei-2020, In: The FEBS Journal. 287, 10, blz. 2105-2117 13 blz.

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  5 Citaten (Scopus)

  45 Downloads (Pure)

• Structural and Functional Characterization of NadR from Lactococcus lactis

  Stetsenko, A., Singh, R., Jähme, M., Guskov, A. & Slotboom, D., 22-apr.-2020, In: Molecules. 25, 8, 14 blz., 1940.

  Onderzoeksoutput › Academic › peer review

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  2 Citaten (Scopus)

  68 Downloads (Pure)

• Structural and functional diversity calls for a new classification of ABC transporters

  Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y., & 23 anderenLewinson, O., Lill, R., Martinoia, E., Murakami, S., Pinket, H. W., Poolman, B., Rosenbaum, D., Sarkadi, B., Schmitt, L., Schneider, E., Shi, Y., Shyng, S-L., Slotboom, D. J., Tajkhorshid, E., Tieleman, D. P., Ueda, K., Váradi, A., Wen, P-C., Yan, N., Zhang, P., Zheng, H., Zimmer, J. & Tampé, R., dec.-2020, In: FEBS Letters. 594, 23, blz. 3767-3775 9 blz., 1873-3468.13935.

  Onderzoeksoutput › Academic › peer review

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  86 Citaten (Scopus)

  46 Downloads (Pure)

• Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

  Arkhipova, V., Guskov, A. & Slotboom, D., 21-feb.-2020, In: Nature Communications. 11, 1, 9 blz., 998.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  35 Citaten (Scopus)

  105 Downloads (Pure)
• 2019

  A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

  Garaeva, A. A., Guskov, A., Slotboom, D. J. & Paulino, C., 31-jul.-2019, In: Nature Communications. 10, 8 blz., 3427.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand
  51 Citaten (Scopus)

  242 Downloads (Pure)

• Binding and transport of D-aspartate by the glutamate transporter homologue GltTk

  Arkhipova, V. I., Trinco, G., Thijs, E., Jensen, S., Slotboom, D. & Guskov, A., 1-mei-2019, In: eLife. 8, 12 blz., e45286.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  16 Citaten (Scopus)

  300 Downloads (Pure)

• ECF-Type ATP-Binding Cassette Transporters

  Rempel, S., Stanek, W. K. & Slotboom, D. J., jun.-2019, In: Annual Review of Biochemistry. 88, blz. 551-576 26 blz., annurev-biochem-013118-111705.

  Onderzoeksoutput › Academic › peer review

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  42 Citaten (Scopus)

  133 Downloads (Pure)

• Energy-Coupling Factor Transporters as Novel Antimicrobial Targets

  Bousis, S., Setyawati, I., Diamanti, E., Slotboom, D. J. & Hirsch, A. K. H., feb.-2019, In: Advanced Therapeutics. 2, 2, 17 blz., 1800066.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  13 Citaten (Scopus)

  88 Downloads (Pure)

• Models to determine the kinetic mechanisms of ion-coupled transporters

  Lolkema, J. S. & Slotboom, D. J., 10-jan.-2019, In: The Journal of General Physiology. 151, 3, blz. 369-380 11 blz.

  Onderzoeksoutput › Academic › peer review

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  5 Citaten (Scopus)

  220 Downloads (Pure)

• Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide binding profiles

  Ejby, M., Guskov, A., Pichler, M. J., Zanten, G. C., Schoof, E., Saburi, W., Slotboom, D. J. & Abou Hachem, M., jul.-2019, In: Molecular Microbiology. 112, 1, blz. 114-130 17 blz., 14257.

  Onderzoeksoutput › Academic › peer review

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  17 Citaten (Scopus)

  108 Downloads (Pure)
• 2018

  Cryo-EM structure of the human neutral amino acid transporter ASCT2

  Garaeva, A., Oostergetel, G., Gati, C., Guskov, A., Batista Paulino, C. & Slotboom, D., 5-jun.-2018, In: Nature Structural & Molecular Biology. 25, blz. 515-521 7 blz.

  Onderzoeksoutput › Academic › peer review

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  84 Citaten (Scopus)

  39 Downloads (Pure)

• Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM

  Rempel, S., Colucci, E., Gier, J-W. D., Guskov, A. & Slotboom, D., 2-aug.-2018, In: Nature Communications. 9, 1, 8 blz., 3038.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  22 Citaten (Scopus)

  321 Downloads (Pure)

• Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

  Luís da Silva Santos Guimarães, J. A., Rempel, S., Mous, S. T. M., Tambascia Pereira, C., ter Beek, J., Gier, J-W. D., Guskov, A. & Slotboom, D., 2018, In: eLife. 7, 16 blz., e35828.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  25 Citaten (Scopus)

  303 Downloads (Pure)

• Glutamate Transporter Inhibitors with Photo-Controlled Activity

  Hoorens, M. W. H., Fu, H., Duurkens, R. H., Trinco, G., Arkhipova, V., Feringa, B. L., Poelarends, G. J., Slotboom, D. J. & Szymanski, W., jun.-2018, In: Advanced Therapeutics. 1, 2, 7 blz., 1800028.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  14 Citaten (Scopus)

  159 Downloads (Pure)
• 2017

  Analysis of the quality of crystallographic data and the limitations of structural models

  Arkhipova, V. I., Guskov, A. & Slotboom, D., dec.-2017, In: The Journal of General Physiology. 149, 12, 13 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  9 Citaten (Scopus)

  370 Downloads (Pure)

• Dynamic combinatorial chemistry to identify binders of ThiT, an S-component of the energy-coupling factor transporter for thiamine

  Monjas, L., Swier, L. J. Y. M., Setyawati, I., Slotboom, D. J. & Hirsch, A. K. H., 20-okt.-2017, In: ChemMedChem. 12, 20, blz. 1693-1696 4 blz.

  Onderzoeksoutput › Academic › peer review

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  8 Citaten (Scopus)

  295 Downloads (Pure)

• Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations

  Swier, L. J. Y. M., Monjas, L., Reeßing, F., Oudshoorn, R. C., Aisyah, A., Primke, T., Bakker, M. M., Van Olst, E., Ritschel, T., Faustino, I., Marrink, S. J., Hirsch, A. K. H. & Slotboom, D. J., 2017, In: MedChemCommun. 8, 5, blz. 1121-1130

  Onderzoeksoutput › Academic › peer review

  Open Access

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  11 Citaten (Scopus)

  22 Downloads (Pure)

• Isolation and characterization of the E. coli membrane protein production strain Mutant56(DE3)

  Baumgarten, T., Schlegel, S., Wagner, S., Löw, M., Eriksson, J., Bonde, I., Herrgård, M. J., Heipieper, H. J., Nørholm, M. H. H., Slotboom, D. J. & de Gier, J-W., 24-mrt.-2017, In: Scientific Reports. 7, blz. 1-14 14 blz., 45089.

  Onderzoeksoutput › Academic › peer review

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  31 Citaten (Scopus)

  287 Downloads (Pure)

• PnuT uses a facilitated diffusion mechanism for thiamine uptake

  Jaehme, M., Singh, R., Garaeva, A. A., Duurkens, R. H. & Slotboom, D-J., dec.-2017, In: Journal of general physiology. 150, 1, blz. 41-50 9 blz., jgp.201711850.

  Onderzoeksoutput › Academic › peer review

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  9 Citaten (Scopus)

  288 Downloads (Pure)

• Single-Molecule Fluorescence Studies of Membrane Transporters Using Total Internal Reflection Microscopy

  Goudsmits, J. M. H., van Oijen, A. M. & Slotboom, D. J., 2017, In: Methods in Enzymology. 594, blz. 101-121 21 blz.

  Onderzoeksoutput › Academic › peer review

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  3 Citaten (Scopus)

  41 Downloads (Pure)

• Single-molecule visualization of conformational changes and substrate transport in the vitamin B-12 ABC importer BtuCD-F

  Goudsmits, J. M. H., Slotboom, D. J. & van Oijen, A. M., 21-nov.-2017, In: Nature Communications. 8, 10 blz., 1652.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  21 Citaten (Scopus)

  302 Downloads (Pure)

• Structure and elevator mechanism of the Na+-citrate transporter CitS

  Lolkema, J. & Slotboom, D., aug.-2017, In: Current Opinion in Structural Biology. 45, blz. 1-9 9 blz.

  Onderzoeksoutput › peer review

  Open Access

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  7 Citaten (Scopus)

  42 Downloads (Pure)

• Tailoring Escherichia coli for the L-rhamnose PBAD promoter-based production of membrane and secretory proteins

  Hjelm, A., Karyolaimos, A., Zhang, Z., Rujas, E., Vikström, D., Slotboom, D. J. & de Gier, J-W., apr.-2017, In: ACS Synthetic Biology. 6, 6, blz. 985-994 10 blz., acssynbio.6b00321.

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  19 Citaten (Scopus)

  75 Downloads (Pure)

• Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides

  Lohse, J., Swier, L. J. Y. M., Oudshoorn, R. C., Médard, G., Kuster, B., Slotboom, D. J. & Witte, M. D., apr.-2017, In: BIOCONJUGATE CHEMISTRY. 28, 4, blz. 913-917 5 blz.

  Onderzoeksoutput › Academic › peer review

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  19 Citaten (Scopus)

  346 Downloads (Pure)

• The structural basis of proton driven zinc transport by ZntB

  Gati, C., Stetsenko, A., Slotboom, D., Scheres, S. & Guskov, A., 3-nov.-2017, In: Nature Communications. 8, 8 blz., 1313.

  Onderzoeksoutput › Academic › peer review

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  16 Citaten (Scopus)

  299 Downloads (Pure)

• The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli

  Kuipers, G., Karyolaimos, A., Zhang, Z., Ismail, N., Trinco, G., Vikstrom, D., Slotboom, D. J. & de Gier, J-W., 16-dec.-2017, In: Microbial Cell Factories. 16, 11 blz., 226.

  Onderzoeksoutput › Academic › peer review

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  7 Citaten (Scopus)

  291 Downloads (Pure)
• 2016

  An ATP Binding Cassette Transporter Mediates the Uptake of alpha-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates

  Ejby, M., Fredslund, F., Andersen, J. M., Zagar, A. V., Henriksen, J. R., Andersen, T. L., Svensson, B., Slotboom, D. J. & Abou Hachem, M., 16-sep.-2016, In: The Journal of Biological Chemistry. 291, 38, blz. 20220-20231 12 blz.

  Onderzoeksoutput › Academic › peer review

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  37 Citaten (Scopus)

  19 Downloads (Pure)

• Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk

  Guskov, A., Jensen, S., Faustino, I., Marrink, S. J. & Slotboom, D. J., 2016, In: Nature Communications. 7, blz. 1-6 6 blz., 13420.

  Onderzoeksoutput › Academic › peer review

  Open Access

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  66 Citaten (Scopus)

  319 Downloads (Pure)

• Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria

  Monjas, L., Swier, L. J. Y. M., de Voogd, A. R., Oudshoorn, R. C., Hirsch, A. K. H. & Slotboom, D. J., 2016, In: MedChemCommun. 7, 5, blz. 966-971 6 blz.

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  6 Citaten (Scopus)

  20 Downloads (Pure)

• Pnu Transporters: Ain't They SWEET?

  Jähme, M., Guskov, A. & Slotboom, D. J., feb.-2016, In: Trends in Biochemical Sciences. 41, 2, blz. 117-118 2 blz.

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  4 Citaten (Scopus)

  8 Downloads (Pure)

• Relative rates of amino acid import via the ABC transporter GlnPQ determine the growth performance of Lactococcus lactis

  Fulyani, F., Schuurman-Wolters, G., Slotboom, D-J. & Poolman, B., feb.-2016, In: Journal of Bacteriology. 198, 3, blz. 477-485 9 blz., JB.00685-15.

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  13 Citaten (Scopus)

  6 Downloads (Pure)