Floris Grasmeijer

2025

Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin in Children with Cystic Fibrosis

Akkerman-Nijland, A. M., Hagedoorn, P., Rottier, B. L., Grasmeijer, F., Frijlink, H. E. W., van Luin, M., Ter Weijden, E., Merkus, P. J., Touw, D. J., Akkerman, O. W. & Koppelman, G. H., 7-mrt.-2025, In: Pharmaceutics. 17, 3, 14 blz., 347.

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2023

Pulmonary

de Boer, A., Hagedoorn, P. & Grasmeijer, F., jun.-2023, Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition. Le Brun, P., Crauste-Manciet, S., Krämer, I., Smith, J. & Woerdenbag, H. (uitgave). Springer International Publishing AG, blz. 299-335 37 blz.

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1 Citaat (Scopus)

125 Downloads (Pure)

2022

Dry powder inhalation, part 1: Ancient history and precursors to modern dry powder inhalers

de Boer, A. H., Hagedoorn, P. & Grasmeijer, F., 2022, In: Expert Opinion on Drug Delivery. 19, 9, blz. 1033-1044 12 blz.

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6 Citaten (Scopus)

139 Downloads (Pure)

Dry powder inhalation, part 2: the present and future

de Boer, A. H., Hagedoorn, P. & Grasmeijer, F., 2022, In: Expert Opinion on Drug Delivery. 19, 9, blz. 1045-1059 15 blz.

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11 Citaten (Scopus)

312 Downloads (Pure)

Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers

de Reus, Y. A., Hagedoorn, P., Sturkenboom, M. G. G., Grasmeijer, F., Bolhuis, M. S., Sibum, I., Kerstjens, H. A. M., Frijlink, H. W. & Akkerman, O. W., 5-aug.-2022, In: PLoS ONE. 17, 8, 12 blz., e0272034.

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5 Citaten (Scopus)

100 Downloads (Pure)

2021

Geïnhaleerde levodopa voor het couperen van OFF-fases bij de ziekte van Parkinson

Grasmeijer, F., Hagedoorn, P. & Luinstra, M., 11-okt.-2021, In: Tijdschrift voor Neurologie en Neurochirurgie. 122, 8, 5 blz., 8.

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18 Downloads (Pure)

Natural and bioinspired excipients for dry powder inhalation formulations

Zillen, D., Beugeling, M., Hinrichs, W. L. J., Frijlink, H. W. & Grasmeijer, F., dec.-2021, In: Current Opinion in Colloid and Interface Science. 56, 17 blz., 101497.

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37 Citaten (Scopus)

559 Downloads (Pure)

The pharmacokinetics of antibiotics in cystic fibrosis

Akkerman-Nijland, A. M., Akkerman, O. W., Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., Rottier, B. L., Koppelman, G. H. & Touw, D. J., jan.-2021, In: Expert Opinion on Drug Metabolism & Toxicology. 17, 1, blz. 53-68 16 blz.

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47 Citaten (Scopus)

415 Downloads (Pure)

2020

A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers

Hagedoorn, P., Bawary, W., Frijlink, H. W. & Grasmeijer, F., mrt.-2020, In: The Journal of Allergy and Clinical Immunology: In Practice. 8, 3, blz. 1124-1125.e4

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14 Citaten (Scopus)

184 Downloads (Pure)

Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops(R)High Dose Dry Powder Inhalation Device While Maintaining Dispersibility

Sibum, I., Hagedoorn, P., Botterman, C. O., Frijlink, H. W. & Grasmeijer, F., jul.-2020, In: Pharmaceutics. 12, 7, blz. 1-14 14 blz., 645.

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13 Citaten (Scopus)

102 Downloads (Pure)

Colistin dry powder inhalation with the Twincer (TM): An effective and more patient friendly alternative to nebulization

Akkerman-Nijland, A. M., Grasmeijer, F., Kerstjens, H. A. M., Frijlink, H. W., van der Vaart, H., Vonk, J. M., Hagedoorn, P., Rottier, B. L., Koppelman, G. H. & Akkerman, O. W., 24-sep.-2020, In: PLoS ONE. 15, 9, 12 blz., e0239658.

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13 Citaten (Scopus)

128 Downloads (Pure)

Comparing five antistatic valved holding chambers: How antistatic are they really?

Hagedoorn, P., Grasmeijer, F., Bawari, W., Frijlink, H. W. & Grasmeijer, F., 7-sep.-2020, In: European Respiratory Journal. 56, 2 blz.

Onderzoeksoutput › Academic

Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine

Sibum, I., Hagedoorn, P., Kluitman, M. P. G., Kloezen, M., Frijlink, H. W. & Grasmeijer, F., jan.-2020, In: Pharmaceutics. 12, 1, 14 blz., 24.

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36 Citaten (Scopus)

183 Downloads (Pure)

Ook antistatische voorzetkamers zijn niet één-op-een uitwisselbaar bij inhalatietherapie

Hagedoorn, P. & Grasmeijer, F., 1-feb.-2020, In: COPD & Astma bulletin huisartsengeneeskunde. 1, 1 blz.

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504 Downloads (Pure)

Optimisation of an isoniazid dry powder formulation for pulmonary administration

Sibum, I., Grasmeijer, F., Hagedoorn, P. & Frijlink, H. W., 1-apr.-2020, In: Journal of aerosol medicine and pulmonary drug delivery. 33, 2, blz. A2-A2 1 blz.

Onderzoeksoutput › Academic

Relative lung dose from antistatic valved holding chambers Reply

Hagedoorn, P., Bawary, W., Frijlink, H. W. & Grasmeijer, F., mrt.-2020, In: The Journal of Allergy and Clinical Immunology: In Practice. 8, 3, blz. 1166-1167 2 blz.

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101 Downloads (Pure)

2019

Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation

Sibum, I., Hagedoorn, P., Frijlink, H. W. & Grasmeijer, F., 13-mei-2019, In: Pharmaceutics. 11, 5, 15 blz., 233.

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28 Citaten (Scopus)

215 Downloads (Pure)

Formulating Amikacin for dry powder inhalation

Sibum, I., Grasmeijer, F., Hagedoorn, P. & Frijlink, H. W., 1-apr.-2019, In: Journal of aerosol medicine and pulmonary drug delivery. 32, 2, blz. A7-A7 1 blz.

Onderzoeksoutput › Academic

Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson's disease

Luinstra, M., Rutgers, W., van Laar, T., Grasmeijer, F., Begeman, A., Isufi, V., Steenhuis, L., Hagedoorn, P., de Boer, A. & Frijlink, H. W., 2019, In: Therapeutic advances in chronic disease. 10, 10 blz.

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14 Citaten (Scopus)

258 Downloads (Pure)

2018

Challenges for pulmonary delivery of high powder doses

Sibum, I., Hagedoorn, P., de Boer, A. H., Frijlink, H. W. & Grasmeijer, F., 5-sep.-2018, In: International Journal of Pharmaceutics. 548, 1, blz. 325-336 12 blz.

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63 Citaten (Scopus)

684 Downloads (Pure)

Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis

Akkerman, O. W., Grasmeijer, F., de Lange, W. C. M., Kerstjens, H. A. M., de Vries, G., Bolhuis, M. S., Alffenaar, J.-W., Frijlink, H. W., Smith, G., Gajraj, R., de Zwaan, R., Hagedoorn, P., Dedicoat, M., van Soolingen, D. & van der Werf, T. S., 22-mrt.-2018, In: European Respiratory Journal. 51, 3, 4 blz., 1702490.

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9 Citaten (Scopus)

324 Downloads (Pure)

FORMULATING ISONIAZID FOR DRY POWDER INHALATION BY SPRAY DRYING

Sibum, I., Grasmeijer, F., Hagedoorn, P. & Frijlink, H. W., apr.-2018, In: Journal of aerosol medicine and pulmonary drug delivery. 31, 2, blz. A2-A2 1 blz.

Onderzoeksoutput › Academic

PHARMACOKINETIC EVALUATION AND TOLERABILITY OF INHALED DRY POWDER LEVODOPA IN PARKINSON'S DISEASE PATIENTS

Luinstra, M., Rutgers, A. W. F., Vroegop, S. J., Begeman, A., Lexmond, A. J., Grasmeijer, F., Hagedoorn, P., de Boer, A. H. & Frijlink, H. W., apr.-2018, In: Journal of aerosol medicine and pulmonary drug delivery. 31, 2, blz. A9-A9 1 blz.

Onderzoeksoutput › Academic

RE-DESIGNING THE COLISTIMETHATE SODIUM TWINCER (R) FOR LARGE-SCALE PRODUCTION

Grasmeijer, F., Hagedoorn, P. & de Boer, A. H., apr.-2018, In: Journal of aerosol medicine and pulmonary drug delivery. 31, 2, blz. A12-A12 1 blz.

Onderzoeksoutput › Academic

2017

Characterisation of jet-milled and spray dried isoniazid for pulmonary administration

Sibum, I., Grasmeijer, F., Hagedoorn, P. & Frijlink, H. W., aug.-2017, In: Journal of aerosol medicine and pulmonary drug delivery. 30, 4, blz. A2 1 blz.

Onderzoeksoutput › Academic

Dry powder inhalation: past, present and future

de Boer, A., Hagedoorn, P., Hoppentocht, M., Buttini, F., Grasmeijer, F. & Frijlink, H. W., apr.-2017, In: Expert Opinion on Drug Delivery. 14, 4, blz. 499-512 14 blz.

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218 Citaten (Scopus)

1626 Downloads (Pure)

2016

A LEVODOPA WITH L-LEUCINE INHALATION POWDER FOR USE IN PARKINSON'S DISEASE

Luinstra, M., Grasmeijer, F., Hagedoorn, P. & Frijlink, H. W., jun.-2016, In: Journal of aerosol medicine and pulmonary drug delivery. 29, 3, blz. A15-A15 1 blz.

Onderzoeksoutput › Academic

In vitro evaluation of the Twincer colistin dry powder inhaler as a non-cough-inducing alternative to Colobreathe

Hagedoorn, P., Grasmeijer, F., Hoppentocht, M., Akkerman, O., Frijlink, H. & De Boer, A., 1-sep.-2016, In: European Respiratory Journal. 48, Suppl.60

Onderzoeksoutput › Academic

Open Access

2015

A levodopa dry powder inhaler for the treatment of Parkinson's disease patients in off periods

Luinstra, M., Grasmeijer, F., Hagedoorn, P., Moes, J. R., Frijlink, H. W. & De Boer, A. H., nov.-2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 97, blz. 22-29 8 blz.

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34 Citaten (Scopus)

228 Downloads (Pure)

Can patients with Parkinson's disease use dry powder inhalers during off periods?

Luinstra, M., Rutgers, A. W. F., Dijkstra, H., Grasmeijer, F., Hagedoorn, P., Vogelzang, J. M. J., Frijlink, H. W. & De Boer, A. H., 14-jul.-2015, In: PLoS ONE. 10, 7, 12 blz., e0132714.

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14 Citaten (Scopus)

261 Downloads (Pure)

Inhalation manoeuvre performed by Parkinson's patients during an off period

Luinstra, M., Rutgers, W., Dijkstra, H., Grasmeijer, F., Hagedoorn, P., Vogelzang, J., Frijlink, H. & De Boer, A., 1-sep.-2015, In: European Respiratory Journal. 46, Supl. 59

Onderzoeksoutput › Academic

Recent advances in the fundamental understanding of adhesive mixtures for inhalation

Grasmeijer, F., Grasmeijer, N., Hagedoorn, P., Frijlink, H. W. & de Boer, A. H., 2015, In: Current Pharmaceutical Design. 21, 40, blz. 5900-5914 15 blz.

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43 Citaten (Scopus)

91 Downloads (Pure)

The ability of Parkinson's disease patients to use dry powder inhalers during off periods

Luinstra, M., Rutgers, W. A. W. F., Dijkstra, H., Grasmeijer, F., Hagedoorn, P., Vogelzang, J., Frijlink, H. W. & De Boer, A. H., 1-jun.-2015, In: Movement Disorders. 30, blz. 101 1 blz.

Onderzoeksoutput › Academic

2014

Adhesive mixtures for inhalation: the cohesion between formulation variables, inhalation variables and dispersion performance

Grasmeijer, F., 2014, [S.l.]: [S.n.]. 193 blz.

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899 Downloads (Pure)

A proposed definition of the 'activity' of surface sites on lactose carriers for dry powder inhalation

Grasmeijer, F., Frijlink, H. W. & de Boer, A., 2-jun.-2014, In: European Journal of Pharmaceutical Sciences. 56, 1, blz. 102-104 3 blz.

Onderzoeksoutput › Academic › peer review

24 Citaten (Scopus)

CARS microscopy as a tool for studying the distribution of micronised drugs in adhesive mixtures for inhalation

Fussell, A. L., Grasmeijer, F., Frijlink, H. W., de Boer, A. H. & Offerhaus, H. L., jul.-2014, In: Journal of Raman Spectroscopy. 45, 7, blz. 495-500 6 blz.

Onderzoeksoutput: Article › Academic › peer review

22 Citaten (Scopus)

New mechanisms to explain the effects of added lactose fines on the dispersion performance of adhesive mixtures for inhalation

Grasmeijer, F., Lexmond, A. J., van den Noort, M., Hagedoorn, P., Hickey, A. J., Frijlink, H. W. & de Boer, A., 28-jan.-2014, In: PLoS ONE. 9, 1, 11 blz., e87825.

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