Frank Dekker

Zoekresultaten

• 2023

  Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto

  Zwinderman, R. H. & Dekker, F. J., 26-jan.-2023, Octrooi Nr. WO2023003468, 22-jul.-2022, Prioriteitsdatum 23-jul.-2021

  Onderzoeksoutput

  Open Access

  Bestand
  9 Downloads (Pure)
• 2022

  4-Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2

  Xiao, Z., Chen, D., Mulder, F., Song, S., van der Wouden, P. E., Cool, R. H., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 3-jan.-2022, In: Chemistry. 28, 1, e202103030.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  68 Downloads (Pure)

• Discovery of chromene compounds as inhibitors of PvdQ acylase of Pseudomonas aeruginosa

  Vogel, J. G. T., Wibowo, J. P., Fan, H., Setroikromo, R., Wang, K., Dömling, A., Dekker, F. J. & Quax, W. J., 27-okt.-2022, In: Microbes and infection. 24, 7 blz., 105017.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  15 Downloads (Pure)

• Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

  Song, S., Xiao, Z., Dekker, F. J., Poelarends, G. J. & Melgert, B. N., feb.-2022, In: Cellular and molecular life sciences. 79, 2, blz. 105 19 blz., 105.

  Onderzoeksoutput › peer review

  Open Access

  Bestand
  7 Citaten (Scopus)

  73 Downloads (Pure)

• Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras

  Zhao, C. & Dekker, F. J., 2022, In: ACS Pharmacology & Translational Science. 5, 9, blz. 710-723 14 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  46 Downloads (Pure)

• Thieno[2,3- d]pyrimidine-2,4(1 H,3 H)-dione Derivative Inhibits d -Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells

  Xiao, Z., Osipyan, A., Song, S., Chen, D., Schut, R. A., van Merkerk, R., van der Wouden, P. E., Cool, R. H., Quax, W. J., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 10-feb.-2022, In: Journal of Medicinal Chemistry. 65, 3, blz. 2059-2077

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  4 Citaten (Scopus)

  30 Downloads (Pure)
• 2021

  Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows

  Klont, F., Kwiatkowski, M., Faiz, A., van den Bosch, T., Pouwels, S. D., Dekker, F. J., Ten Hacken, N. H. T., Horvatovich, P. & Bischoff, R., 5-nov.-2021, In: Journal of Proteome Research. 20, 11, blz. 5218–5221 4 blz.

  Onderzoeksoutput: Letter › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  8 Downloads (Pure)

• Biaryl sulfonamides as cisoid azosteres for photopharmacology

  Kobauri, P., Szymanski, W., Cao, F., Thallmair, S., Marrink, S. J., Witte, M. D., Dekker, F. J. & Feringa, B. L., 27-apr.-2021, In: Chemical Communications. 57, 34, blz. 4126-4129 4 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  4 Citaten (Scopus)

  42 Downloads (Pure)

• Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes—a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS

  van Pijkeren, A., Dietze, J., Brotons, A. S., Egger, A-S., Lijster, T., Barcaru, A., Hotze, M., Kobler, P., Dekker, F. J., Horvatovich, P., Melgert, B. N., Ziegler, M., Thedieck, K., Heiland, I., Bischoff, R. & Kwiatkowski, M., 28-sep.-2021, In: Analytical Chemistry. 93, 38, blz. 12872-12880 9 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  33 Downloads (Pure)

• Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions

  Zwinderman, M. R. H., Lobo, T. J., van der Wouden, P. E., Spierings, D. C. J., van Vugt, M. A. T. M., Lansdorp, P. M., Guryev, V. & Dekker, F. J., 19-nov.-2021, In: ACS chemical biology. 16, 11, blz. 2193-2201 9 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  65 Downloads (Pure)

• Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

  Osipyan, A., Chen, D. & Dekker, F. J., jul.-2021, In: Drug Discovery Today. 26, 7, blz. 1728-1734

  Onderzoeksoutput › peer review

  Open Access

  Bestand
  9 Citaten (Scopus)

  56 Downloads (Pure)

• Experimental approaches toward histone acetyltransferase modulators as therapeutics

  Chen, D., Wapenaar, H. & Dekker, F. J., 1-jan.-2021, Medical Epigenetics. Tollefsbol, T. (redactie). 2nd redactie Elsevier, blz. 665-692 28 blz.

  Onderzoeksoutput › Academic › peer review

• HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway

  Cao, F., Xiao, Z., Chen, S., Zhao, C., Chen, D., Haisma, H. J. & Dekker, F. J., dec.-2021, In: Bioorganic Chemistry. 117, 8 blz., 105396.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  5 Citaten (Scopus)

  34 Downloads (Pure)

• Identification of a Bromodomain-like region in 15-Lipoxygenase-1 explains its Nuclear Localization

  Chen, D., Xiao, Z., Guo, H., Gogishvili, D., Setroikromo, R., van der Wouden, P. E. & Dekker, F. J., 27-sep.-2021, In: Angewandte Chemie (International ed. in English). 60, 40, blz. 21875-21883 21875 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  2 Citaten (Scopus)

  25 Downloads (Pure)

• Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells

  Xiao, Z., Song, S., Chen, D., van Merkerk, R., van der Wouden, P., Cool, R., Quax, W., Poelarends, G., Melgert, B. & Dekker, F. J., 2-aug.-2021, In: Angewandte Chemie (International ed. in English). 60, 32, blz. 17514-17521 9 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  13 Citaten (Scopus)

  53 Downloads (Pure)
• 2020

  7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor

  Xiao, Z., Chen, D., Song, S., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., Cool, R., Hirsch, A. K. H., Melgert, B., Quax, W. J., Poelarends, G. J. & Dekker, F. J., 22-okt.-2020, In: Journal of Medicinal Chemistry. 63, 20, blz. 11920-11933 14 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  12 Citaten (Scopus)

  270 Downloads (Pure)

• A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL

  Zhang, B., Chen, D., Liu, B., Dekker, F. J. & Quax, W. J., mei-2020, In: Biochemical Pharmacology. 175, 10 blz., 113914.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  12 Citaten (Scopus)

  105 Downloads (Pure)

• A novel mechanism of inhibition by phenylthiourea on PvdP, a tyrosinase synthesizing pyoverdine of Pseudomonas aeruginosa

  Wibowo, J. P., Batista, F. A., van Oosterwijk, N., Groves, M. R., Dekker, F. J. & Quax, W. J., 1-mrt.-2020, In: International Journal of Biological Macromolecules. 146, blz. 212-221 10 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  13 Citaten (Scopus)

  257 Downloads (Pure)

• Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs

  Sinitski, D., Gruner, K., Brandhofer, M., Kontos, C., Winkler, P., Reinstädler, A., Bourilhon, P., Xiao, Z., Cool, R. H., Kapurniotu, A., Dekker, F. J., Panstruga, R. & Bernhagen, J., 17-jan.-2020, In: The Journal of Biological Chemistry. 295, 3, blz. 850-867 18 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  6 Citaten (Scopus)

  165 Downloads (Pure)

• Development of phenylthiourea derivatives as allosteric inhibitors of pyoverdine maturation enzyme PvdP tyrosinase

  Wibowo, J. P., Xiao, Z., Voet, J. M., Dekker, F. J. & Quax, W. J., 1-sep.-2020, In: Bioorganic & Medicinal Chemistry Letters. 30, 17, 6 blz., 127409.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  2 Citaten (Scopus)

  81 Downloads (Pure)

• ElectrochemicalN-demethylation of tropane alkaloids

  Alipour Najmi, A., Xiao, Z., Bischoff, R., Dekker, F. J. & Permentier, H. P., 7-okt.-2020, In: Green Chemistry. 22, 19, blz. 6455-6463 9 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  8 Citaten (Scopus)

  123 Downloads (Pure)

• Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications

  Zhang, B., Chen, D., Dekker, F. & Quax, W. J., 9-okt.-2020, In: Cancer Drug Resistance. 2020, 3, blz. 1-13 13 blz., CDR 2020-58.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  1 Citaat (Scopus)

  334 Downloads (Pure)

• Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)

  Cao, F., de Weerd, S., Chen, D., Zwinderman, M. R. H., van der Wouden, P. E. & Dekker, F. J., 15-dec.-2020, In: European Journal of Medicinal Chemistry. 208, 112800.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  30 Citaten (Scopus)

  118 Downloads (Pure)

• Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

  Liu, B., Chen, S., Chen, D., Cao, F., Zwinderman, M., Kiemel, D., Aïssi, M., Dekker, F. J., Haisma, H. J. & La Rose, A., 24-jan.-2020, In: Nucleic Acids Research. 48, 2, blz. 517-532 16 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  20 Citaten (Scopus)

  146 Downloads (Pure)

• Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability inSchistosoma mansoni

  Carneiro, V. C., de Abreu Silva, I. C., Amaral, M. S., Pereira, A. S. A., Silveira, G. O., Pires, D. D. S., Verjovski-Almeida, S., Dekker, F. J., Rotili, D., Mai, A., Lopes-Torres, E. J., Robaa, D., Sippl, W., Pierce, R. J., Borrello, M. T., Ganesan, A., Lancelot, J., Thiengo, S., Fernandez, M. A., Revoredo Vicentino, A. R., & 3 anderenMourao, M. M., Coelho, F. S. & Fantappie, M. R., 1-jul.-2020, In: PLoS Neglected Tropical Diseases. 14, 7, blz. 1-29 29 blz., 0008332.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  5 Citaten (Scopus)

  95 Downloads (Pure)

• SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells

  Krabbendam, I. E., Honrath, B., Bothof, L., Silva-Pavez, E., Huerta, H., Peñaranda Fajardo, N. M., Dekker, F., Schmidt, M., Culmsee, C., César Cárdenas, J., Kruyt, F. & Dolga, A. M., jan.-2020, In: Biochemical Pharmacology. 171, 13 blz., 113714.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  9 Citaten (Scopus)

  102 Downloads (Pure)

• SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

  Krabbendam, I. E., Honrath, B., Dilberger, B., Iannetti, E. F., Branicky, R. S., Meyer, T., Evers, B., Dekker, F. J., Koopman, W. J. H., Beyrath, J., Bano, D., Schmidt, M., Bakker, B. M., Hekimi, S., Culmsee, C., Eckert, G. P. & Dolga, A. M., 23-apr.-2020, In: Cell death & disease. 11, 4, 18 blz., 263.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  15 Citaten (Scopus)

  142 Downloads (Pure)

• Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF)

  Xiao, Z., Fokkens, M., Chen, D., Kok, T., Proietti, G., Van Merkerk, R., Poelarends, G. J. & Dekker, F. J., 15-jan.-2020, In: European Journal of Medicinal Chemistry. 186, 13 blz., 111849.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  10 Citaten (Scopus)

  151 Downloads (Pure)

• The genetics of asthma and the promise of genomics-guided drug target discovery

  El-Husseini, Z. W., Gosens, R., Dekker, F. & Koppelman, G. H., okt.-2020, In: The Lancet. Respiratory Medicine. 8, 10, blz. 1045-1056 13 blz.

  Onderzoeksoutput › peer review

  Open Access

  Bestand
  52 Citaten (Scopus)

  390 Downloads (Pure)
• 2019

  Acetylation and Methylation in Asthma, COPD, and Lung Cancer

  Zwinderman, M., Cao, F. & Dekker, F., 2019, Chemical Epigenetics: Topics in Medicinal Chemistry. Mai, A. (redactie). Cham: Springer Nature, blz. 429-455 25 blz. (Topics in Medicinal Chemistry; vol. 33).

  Onderzoeksoutput › Professional

  Open Access

  Bestand
  1 Citaat (Scopus)

  6 Downloads (Pure)

• A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1

  van der Vlag, R., Guo, H., Hapko, U., Eleftheriadis, N., Monjas, L., Dekker, F. J. & Hirsch, A. K. H., 15-jul.-2019, In: European Journal of Medicinal Chemistry. 174, blz. 45-55 11 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  11 Citaten (Scopus)

  45 Downloads (Pure)

• A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices

  Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J. & Olinga, P., 27-feb.-2019, In: Nutrients. 11, 3, 14 blz., 507.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  11 Citaten (Scopus)

  319 Downloads (Pure)

• Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes sortase A

  Wójcik, M., Eleftheriadis, N., Zwinderman, M. R. H., Dömling, A. S. S., Dekker, F. J. & Boersma, Y. L., jan.-2019, In: European Journal of Medicinal Chemistry. 161, blz. 93-100 8 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  5 Citaten (Scopus)

  38 Downloads (Pure)

• Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages

  Cao, F., Zwinderman, M., van Merkerk, R., Ettema, P., Quax, W. & Dekker, F. J., 1-sep.-2019, In: European Journal of Medicinal Chemistry. 177, blz. 457-466 10 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  10 Citaten (Scopus)

  158 Downloads (Pure)

• Light-controlled inhibition of BRAFV600E kinase

  Hoorens, M. W. H., Ourailidou, M. E., Rodat, T., van der Wouden, P. E., Kobauri, P., Kriegs, M., Peifer, C., Feringa, B. L., Dekker, F. J. & Szymanski, W., 1-okt.-2019, In: European Journal of Medicinal Chemistry. 179, blz. 133-146 14 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  22 Citaten (Scopus)

  72 Downloads (Pure)

• Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

  Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., Quax, W. J., Olinga, P., Hirsch, A. K. H. & Dekker, F. J., 9-mei-2019, In: Journal of Medicinal Chemistry. 62, 9, blz. 4624-4637 14 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  11 Citaten (Scopus)

  273 Downloads (Pure)

• POLYUNSATURATED FATTY ACIDS AND 5-LIPOXYGENASE IN NON-ALCOHOLIC FATTY LIVER DISEASE

  Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Dekker, F. J., Olinga, P. & Gier, K., okt.-2019, In: Hepatology. 70, blz. 1311A-1311A 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry

  Prismawan, D., van der Vlag, R., Guo, H., Dekker, F. J. & Hirsch, A. K. H., mei-2019, In: Helvetica Chimica Acta. 102, 5, 14 blz., e1900040.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  2 Citaten (Scopus)

  149 Downloads (Pure)

• Small Multitarget Molecules Incorporating the Enone Moiety

  Liargkova, T., Eleftheriadis, N., Dekker, F., Voulgari, E., Avgoustakis, C., Sagnou, M., Mavroidi, B., Pelecanou, M. & Hadjipavlou-Litina, D., 7-jan.-2019, In: Molecules. 24, 1, 31 blz., 199.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  9 Citaten (Scopus)

  233 Downloads (Pure)

• Synthesis of peptoid-based class I selective histone deacetylase inhibitors with chemosensitizing properties

  Krieger, V., Hamacher, A., Cao, F., Stenzel, K., Gertzen, C. G. W., Schäker-Hübner, L., Kurz, T., Gohlke, H., Dekker, F. J., Kassack, M. U. & Hansen, F. K., 26-dec.-2019, In: Journal of Medicinal Chemistry. 62, 24, blz. 11260-11279 20 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  14 Citaten (Scopus)

  90 Downloads (Pure)

• Targeting HDAC Complexes in Asthma and COPD

  Zwinderman, M. R. H., de Weerd, S. & Dekker, F. J., 7-sep.-2019, In: Epigenomes. 3, 3, 25 blz., 19.

  Onderzoeksoutput › peer review

  Open Access

  Bestand
  17 Citaten (Scopus)

  164 Downloads (Pure)
• 2018

  Details in vroege ontwikkelfase enzymremmers onderschat: Aandacht voor remmingsmechanisme misschien tijdrovend, maar moeite waard

  Wapenaar, H. & Dekker, F., 23-mrt.-2018, In: Pharmaceutisch Weekblad.

  Onderzoeksoutput: Article › Professional

• Discovery of chromenes as inhibitors of macrophage migration inhibitory factor

  Kok, T., Wapenaar, H., Wang, K., Neochoritis, C. G., Zarganes-Tzitzikas, T., Proietti, G., Eleftheriadis, N., Kurpiewska, K., Kalinowska-Tłuścik, J., Cool, R. H., Poelarends, G. J., Dömling, A. & Dekker, F. J., 1-mrt.-2018, In: Bioorganic & Medicinal Chemistry. 26, 5, blz. 999-1005 7 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  4 Citaten (Scopus)

  37 Downloads (Pure)

• HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals

  Večeřa, J., Bártová, E., Krejčí, J., Legartová, S., Komůrková, D., Rudá-Kučerová, J., Štark, T., Dražanová, E., Kašpárek, T., Šulcová, A., Dekker, F. J., Szymanski, W., Seiser, C., Weitzer, G., Mechoulam, R., Micale, V. & Kozubek, S., jan.-2018, In: Journal of Cellular Physiology. 233, 1, blz. 530-548 19 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  48 Citaten (Scopus)

  76 Downloads (Pure)

• High yield production of human invariant chain CD74 constructs fused to solubility-enhancing peptides and characterization of their MIF-binding capacities

  Kok, T., Wasiel, A. A., Dekker, F. J., Poelarends, G. J. & Cool, R. H., aug.-2018, In: Protein Expression and Purification. 148, blz. 46-53

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  3 Citaten (Scopus)

  286 Downloads (Pure)

• Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders

  Kok, T., Wasiel, A. A., Cool, R. H., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., nov.-2018, In: Drug Discovery Today. 23, 11, blz. 1910-1918 9 blz.

  Onderzoeksoutput › peer review

  Open Access

  Bestand
  31 Citaten (Scopus)

  241 Downloads (Pure)

• The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors

  Cao, F., Zwinderman, M. R. H. & Dekker, F. J., 2-mrt.-2018, In: Molecules. 23, 3, 13 blz., 551.

  Onderzoeksoutput › peer review

  Open Access

  Bestand
  33 Citaten (Scopus)

  665 Downloads (Pure)
• 2017

  A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

  Bosch, van den, T., Leus, N. G. J., Wapenaar, H., Boichenko, A., Hermans, J., Bischoff, R., Haisma, H. J. & Dekker, F. J., jun.-2017, In: Pulmonary Pharmacology & Therapeutics. 44, blz. 88-95

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  11 Citaten (Scopus)

  3 Downloads (Pure)

• Design, multicomponent synthesis and anticancer activity of a focused histone deacetylase (HDAC) inhibitor library with peptoid-based cap groups

  Krieger, V., Hamacher, A., Gertzen, C. G. W., Senger, J., Zwinderman, M. R. H., Marek, M., Romier, C., Dekker, F. J., Kurz, T., Jung, M., Gohlke, H., Kassack, M. U. & Hansen, F. K., 2-jun.-2017, In: Journal of Medicinal Chemistry. 60, 13, blz. 5493-5506 14 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  30 Citaten (Scopus)

  144 Downloads (Pure)

• HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

  Leus, N. G. J., van den Bosch, T., van der Wouden, P. E., Krist, K., Ourailidou, M. E., Eleftheriadis, N., Kistemaker, L. E. M., Bos, S., Gjaltema, R. A. F., Mekonnen, S. A., Bischoff, R., Gosens, R., Haisma, H. J. & Dekker, F. J., 27-mrt.-2017, In: Scientific Reports. 7, 18 blz., 45047.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand
  53 Citaten (Scopus)

  363 Downloads (Pure)