Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
- 27 resultaten
Zoekresultaten
-
2025
Presence of On-Target Resistant Mutation in Pre-Treatment Samples of ALK Fusion Gene Positive Lung Cancer Patients
Li, W., Zwierenga, F., Andini, K. D., Bucher, J. M., Scherpen, F., Hiltermann, T. J. N., Groen, H. J. M., van der Wekken, A. J., Kok, K. & Berg, A. V. D., apr.-2025, In: Cancers. 17, 7, 13 blz., 1090.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand24 Downloads (Pure) -
2022
The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magalhães, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., jun.-2022, In: Journal of Cell Science. 135, 11, 14 blz., jeb258608.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand5 Citaten (Scopus)156 Downloads (Pure) -
The Presence of EGFR T790M in TKI-Naïve Lung Cancer Samples of Patients Who Developed a T790M-Positive Relapse on First or Second Generation TKI Is Rare
Li, W., Kok, K., Tan, G. W., Meng, P., Mastik, M., Rifaela, N., Scherpen, F., Hiltermann, T. J. N., Groen, H. J. M., Wekken, A. J. V. D. & van den Berg, A., 19-jul.-2022, In: Cancers. 14, 14, 11 blz., 3511.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand2 Citaten (Scopus)74 Downloads (Pure) -
2021
Clinical Value of EGFR Copy Number Gain Determined by Amplicon-Based Targeted Next Generation Sequencing in Patients with EGFR-Mutated NSCLC
Wei, J., Meng, P., Terpstra, M. M., van Rijk, A., Tamminga, M., Scherpen, F., Ter Elst, A., Alimohamed, M. Z., Johansson, L. F., Stigt, J., Gijtenbeek, R. P. G., van Putten, J., Hiltermann, T. J. N., Groen, H. J. M., Kok, K., van der Wekken, A. J. & van den Berg, A., 19-feb.-2021, In: Targeted oncology. 12 blz.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand10 Citaten (Scopus)141 Downloads (Pure) -
CREB signaling activity correlates with differentiation and survival in medulloblastoma
Armandari, I., Zomerman, W. W., Plasschaert, S. L. A., Smit, M. J., Martini, T. E., Magalhaes, E. S. D. C., Hogeling, S. M., Rozema-Huizinga, G. C., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., de Bont, E. S. J. M. & Bruggeman, S. W. M., 9-aug.-2021, In: Scientific Reports. 11, 1, 12 blz., 16077.Onderzoeksoutput › Academic › peer review
Open AccessBestand5 Citaten (Scopus)102 Downloads (Pure) -
2019
Peptide microarray of pediatric acute myeloid leukemia is related to relapse and reveals involvement of DNA damage response and repair
Mahmud, H., Ter Elst, A., Scherpen, F. J. G., Boer, T.M.-D., Kampen, K. R., de Haas, V., Guryev, V., Peppelenbosch, M. M., Kornblau, S. M. & de Bont, E. S. J. M., 23-jul.-2019, In: Oncotarget. 10, 45, blz. 4679-4690 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand5 Citaten (Scopus)111 Downloads (Pure) -
2018
Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma
Zomerman, W. W., Plasschaert, S. L. A., Conroy, S., Scherpen, F. J., Meeuwsen-de Boer, T. G. J., Lourens, H. J., Guerrero Llobet, S., Smit, M. J., Slagter-Menkema, L., Seitz, A., Gidding, C. E. M., Hulleman, E., Wesseling, P., Meijer, L., van Kempen, L. C., van den Berg, A., Warmerdam, D. O., Kruyt, F. A. E., Foijer, F. & van Vugt, M. A. T. M. & 5 anderen, , 20-mrt.-2018, In: Cell reports. 22, 12, blz. 3206-3216 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand17 Citaten (Scopus)367 Downloads (Pure) -
VEGFC Antibody Therapy Drives Differentiation of AML
Kampen, K. R., Scherpen, F. J. G., Mahmud, H., ter Elst, A., Mulder, A. B., Guryev, V., Verhagen, H. J. M. P., De Keersmaecker, K., Smit, L., Kornblau, S. M. & de Bont, E. S. J. M., 15-okt.-2018, In: Cancer Research. 78, 20, blz. 5940-5948 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand12 Citaten (Scopus)145 Downloads (Pure) -
2017
Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML
Mahmud, H., Scherpen, F. J. G., Meeuwsen de Boer, T., Lourens, H.-J., Schoenherr, C., Eder, M., Scherr, M., Guryev, V. & de Bont, E. S., 15-sep.-2017, In: Oncotarget. 8, 40, blz. 67344-67354 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand12 Citaten (Scopus)289 Downloads (Pure) -
2016
Epidermal growth factor receptor is expressed and active in a subset of acute myeloid leukemia
Mahmud, H., Kornblau, S. M., ter Elst, A., Scherpen, F. J. G., Qiu, Y. H., Coombes, K. R. & de Bont, E. S. J. M., 3-aug.-2016, In: Journal of Hematology & Oncology. 9, 1, 3 blz., 64.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand22 Citaten (Scopus)330 Downloads (Pure) -
2015
Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
van der Sligte, N. E., Scherpen, F. J. G., Ter Elst, A., Guryev, V., van Leeuwen, F. N. & de Bont, E. S. J. M., 2015, In: Experimental Hematology & Oncology. 4, 10 blz., 23.Onderzoeksoutput › Academic › peer review
Open AccessBestand353 Downloads (Pure) -
EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System
Kampen, K. R., Scherpen, F. J. G., Garcia-Manero, G., Yang, H., Kaspers, G. J. L., Cloos, J., Zwaan, C. M., van den Heuvel-Eibrink, M. M., Kornblau, S. M. & De Bont, E. S. J. M., jun.-2015, In: Molecular Cancer Research. 13, 6, blz. 982-992 11 blz.Onderzoeksoutput › Academic › peer review
20 Citaten (Scopus) -
Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia
van der Sligte, N. E., Kampen, K. R., ter Elst, A., Scherpen, F. J. G., Meeuwsen-de Boer, T. G. J., Guryev, V., van Leeuwen, F. N., Kornblau, S. M. & de Bont, E. S. J. M., 20-jun.-2015, In: Oncotarget. 6, 17, blz. 14970-14981 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand29 Citaten (Scopus)305 Downloads (Pure) -
Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma
Sie, M., den Dunnen, W. F. A., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., Zomerman, W. W., Kampen, K. R., Hoving, E. W. & de Bont, E. S. J. M., 23-mrt.-2015, In: PLoS ONE. 10, 3, 16 blz., e0122555.Onderzoeksoutput › Academic › peer review
Open AccessBestand22 Citaten (Scopus)670 Downloads (Pure) -
Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: A new approach for target discovery
van der Sligte, N. E., Scherpen, F. J. G., Meeuwsen-de Boer, T. G. J., Lourens, H. J., ter Elst, A., Diks, S. H., Guryev, V., Peppelenbosch, M. P., van Leeuwen, F. N. & de Bont, E. S. J. M., apr.-2015, In: Proteomics. 15, 7, blz. 1245-1254 10 blz.Onderzoeksoutput › Academic › peer review
12 Citaten (Scopus) -
2014
Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML
Kampen, K. R., ter Elst, A., Mahmud, H., Scherpen, F. J. G., Diks, S. H., Peppelenbosch, M. P., de Haas, V., Guryev, V. & de Bont, E. S. J. M., mrt.-2014, In: Leukemia. 28, 3, blz. 589-599 11 blz.Onderzoeksoutput › Academic › peer review
35 Citaten (Scopus) -
2012
EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion
Sikkema, A. H., den Dunnen, W. F. A., Hulleman, E., van Vuurden, D. G., Garcia-Manero, G., Yang, H., Scherpen, F. J. G., Kampen, K. R., Hoving, E. W., Kamps, W. A., Diks, S. H., Peppelenbosch, M. P. & de Bont, E. L. S. J. M., sep.-2012, In: Neuro-Oncology. 14, 9, blz. 1125-1135 11 blz.Onderzoeksoutput › Academic › peer review
42 Citaten (Scopus) -
MBL2 and fever during neutropenia in children with acute lymphoblastic leukaemia
te Poele , E. M., Siedlinski, M., de Pagter, P. J. A., Bierings, M. B., Scherpen, F. J. G., Meeuwsen-de Boer, T. G. J., Koppelman, G. H., Postma, D. S., Kamps, W. A., Boezen, H. M. & De Bont, E. S. J. M., apr.-2012, In: British Journal of Haematology. 157, 1, blz. 132-135 4 blz.Onderzoeksoutput › Academic › peer review
4 Citaten (Scopus) -
2011
Identification of new possible targets for leukemia treatment by kinase activity profiling
Ter Elst, A., Diks, S. H., Kampen, K. R., Hoogerbrugge, P. M., Ruijtenbeek, R., Boender, P. J., Sikkema, A. H., Scherpen, F. J. G., Kamps, W. A., Peppelenbosch, M. P. & de Bont, E. S. J. M., jan.-2011, In: Leukemia and Lymphoma. 52, 1, blz. 122-130 9 blz.Onderzoeksoutput › Academic › peer review
19 Citaten (Scopus) -
Repression of Vascular Endothelial Growth Factor Expression by the Runt-Related Transcription Factor 1 in Acute Myeloid Leukemia
ter Elst, A., Ma, B., Scherpen, F. J. G., de Jonge, H. J. M., Douwes, J., Wierenga, A. T. J., Schuringa, J. J., Kamps, W. A. & de Bont, E. S. J. M., 1-apr.-2011, In: Cancer Research. 71, 7, blz. 2761-2771 11 blz.Onderzoeksoutput › Academic › peer review
28 Citaten (Scopus) -
Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-beta signalling
Weidenaar, A. C., ter Elst, A., Kampen, K. R., Meeuwsen-de Boer, G., de Jonge, H. J. M., Scherpen, F. J. G., den Dunnen, W. F. A., Kamps, W. A. & de Bont, E. S. J. M., 6-dec.-2011, In: British Jounal of Cancer. 105, 12, blz. 1856-1863 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand4 Citaten (Scopus)178 Downloads (Pure) -
2010
Tumour vasculature and angiogenic profile of paediatric pilocytic astrocytoma; is it much different from glioblastoma?
Sie, M., de Bont, E. S. J. M., Scherpen, F. J. G., Hoving, E. W. & den Dunnen, W. F. A., dec.-2010, In: Neuropathology and Applied Neurobiology. 36, 7, blz. 636-647 12 blz.Onderzoeksoutput › Academic › peer review
48 Citaten (Scopus) -
VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms
Roorda, B. D., ter Elst, A., Scherpen, F. J. G., Meemusen-de Boer, T. G. J., Kamps, W. A. & de Bont, E. S. J. M., mrt.-2010, In: European Journal of Cancer. 46, 5, blz. 974-982 9 blz.Onderzoeksoutput › Academic › peer review
13 Citaten (Scopus) -
2009
Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Sikkema, A. H., Diks, S. H., den Dunnen, W. F. A., ter Elst, A., Scherpen, F. J. G., Hoving, E. W., Ruijtenbeek, R., Boender, P. J., de Wijn, R., Kamps, W. A., Peppelenbosch, M. P. & de Bont, E. S. J. M., 15-jul.-2009, In: Cancer Research. 69, 14, blz. 5987-5995 9 blz.Onderzoeksoutput › Academic › peer review
94 Citaten (Scopus) -
2008
Endogenous vascular endothelial growth factor-C expression is associated with decreased drug responsiveness in childhood acute myeloid leukemia
de Jonge, H. J. M., Weidenaar, A. C., Ter Elst, A., Boezen, H., Scherpen, F. J. G., Bouma-Ter Steege, J. C. A., Kaspers, G. J. L., Goemans, B. F., Creutzig, U., Zimmermann, M., Kamps, W. A. & de Bont, E. S. J. M., 1-feb.-2008, In: Clinical Cancer Research. 14, 3, blz. 924-930 7 blz.Onderzoeksoutput › Academic › peer review
21 Citaten (Scopus) -
2002
Vascular endothelial growth factor secretion is an independent prognostic factor for relapse-free survival in pediatric acute myeloid leukemia patients
de Bont, E., Fidler, [. V., Meeuwsen, T., Scherpen, F., Hahlen, K. & Kamps, W., sep.-2002, In: Clinical Cancer Research. 8, 9, blz. 2856-2861 6 blz.Onderzoeksoutput › Academic › peer review
62 Citaten (Scopus) -
2001
Mobilized human CD34+hematopoietic stem cells enhance tumor growth in a nonobese diabetic/severe combined immunodeficient mouse model of human non-Hodgkin's lymphoma
de Bont, E., Guikema, J., Scherpen, F., Meeuwsen, T., Kamps, W., Vellenga, E. & Bos, N., 15-okt.-2001, In: Cancer Research. 61, 20, blz. 7654-7659 6 blz.Onderzoeksoutput › Academic › peer review
55 Citaten (Scopus)