Hein Schepers

2022

Coenzyme A precursors flow from mother to zygote and from microbiome to host

Yu, Y., van der Zwaag, M., Wedman, J. J., Permentier, H., Plomp, N., Jia, X., Kanon, B., Eggens-Meijer, E., Buist, G., Harmsen, H., Kok, J., Salles, J. F., Wertheim, B., Hayflick, S. J., Strauss, E., Grzeschik, N. A., Schepers, H. & Sibon, O. C. M., 21-jul.-2022, In: Molecular Cell. 82, 14, blz. 2650-2665.e12 29 blz.

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12 Citaten (Scopus)

195 Downloads (Pure)

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Huiting, W., Dekker, S. L., van der Lienden, J. C. J., Mergener, R., Musskopf, M. K., Furtado, G. V., Gerrits, E., Coit, D., Oghbaie, M., Di Stefano, L. H., Schepers, H., van Waarde-Verhagen, M. A. W. H., Couzijn, S., Barazzuol, L., LaCava, J., Kampinga, H. H. & Bergink, S., 24-feb.-2022, In: eLife. 11, 29 blz., e70726.

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11 Citaten (Scopus)

142 Downloads (Pure)

2021

The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury

Rocchi, C., Cinat, D., Serrano Martinez, P., Jellema-de Bruin, A. L., Baanstra, M., Brouwer, U., Del Angel Zuivre, C., Schepers, H., van Os, R., Barazzuol, L. & Coppes, R. P., 7-dec.-2021, In: Science signaling. 14, 712, 11 blz., 0599.

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10 Citaten (Scopus)

277 Downloads (Pure)

2020

Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle

Cong, Y., Ulasli, M., Schepers, H., Mauthe, M., V'kovski, P., Kriegenburg, F., Thiel, V., de Haan, C. A. M. & Reggiori, F., feb.-2020, In: Journal of Virology. 94, 4, 21 blz., ARTN e01925-19.

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264 Citaten (Scopus)

127 Downloads (Pure)

Vps13 is required for timely removal of nurse cell corpses

Faber, A. I. E., van der Zwaag, M., Schepers, H., Eggens-Meijer, E., Kanon, B., IJsebaart, C., Kuipers, J., Giepmans, B. N. G., Freire, R., Grzeschik, N. A., Rabouille, C. & Sibon, O. C. M., 29-okt.-2020, In: DEVELOPMENT. 147, 20, 15 blz., 191759.

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9 Citaten (Scopus)

160 Downloads (Pure)

2019

CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions

Jung, J., Buisman, S. C., Weersing, E., Dethmers-Ausema, A., Zwart, E., Schepers, H., Dekker, M. R., Lazare, S. S., Hammerl, F., Skokova, Y., Kooistra, S. M., Klauke, K., Poot, R. A., Bystrykh, L. V. & de Haan, G., 12-feb.-2019, In: Cell reports. 26, 7, blz. 1906-1918.e8 21 blz.

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26 Citaten (Scopus)

316 Downloads (Pure)

CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases

Lambrechts, R. A., Schepers, H., Yu, Y., van der Zwaag, M., Autio, K. J., Vieira-Lara, M. A., Bakker, B. M., Tijssen, M. A., Hayflick, S. J., Grzeschik, N. A. & Sibon, O. C., 7-nov.-2019, In: EMBO Molecular Medicine. 21 blz., 10488.

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47 Citaten (Scopus)

286 Downloads (Pure)

Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern

Berger, G., Gerritsen, M., Yi, G., Koorenhof-Scheele, T. N., Kroeze, L. I., Stevens-Kroef, M., Yoshida, K., Shiraishi, Y., van den Berg, E., Schepers, H., Huls, G., Mulder, A. B., Ogawa, S., Martens, J. H. A., Jansen, J. H. & Vellenga, E., 22-okt.-2019, In: Blood. 3, 20, blz. 3111-3122 12 blz.

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6 Citaten (Scopus)

35 Downloads (Pure)

Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells

Mattes, K., Geugien, M., Korthuis, P. M., Brouwers-Vos, A. Z., Fehrmann, R. S. N., Todorova, T. I., Steidl, U., Vellenga, E. & Schepers, H., mei-2019, In: Experimental Hematology. 73, blz. 38-49 12 blz.

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3 Citaten (Scopus)

163 Downloads (Pure)

2018

Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT

Berger, G., Kroeze, L. I., Koorenhof-Scheele, T. N., de Graaf, A. O., Yoshida, K., Ueno, H., Shiraishi, Y., Miyano, S., van den Berg, E., Schepers, H., van der Reijden, B. A., Ogawa, S., Vellenga, E. & Jansen, J. H., 19-apr.-2018, In: Blood. 131, 16, blz. 1846-1857 12 blz.

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38 Citaten (Scopus)

42 Downloads (Pure)

2017

CITED2 affects leukemic cell survival by interfering with p53 activation

Mattes, K., Berger, G., Geugien, M., Vellenga, E. & Schepers, H., 1-jan.-2017, In: Cell death & disease. 8, 10, 10 blz., 3132.

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16 Citaten (Scopus)

377 Downloads (Pure)

2015

CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia

Korthuis, P. M., Berger, G., Bakker, B., Rozenyeld-Geugien, M., Jaques, J., de Haan, G., Schuringa, J. J., Vellenga, E. & Schepers, H., mrt.-2015, In: Leukemia. 29, 3, blz. 625-635 11 blz.

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25 Citaten (Scopus)

Impact of genetic variation in the SMIM1 gene on Vel expression levels

Haer-Wigman, L., Stegmann, T. C., Solati, S., Ait Soussan, A., Beckers, E., van der Harst, P., van Hulst-Sundermeijer, M., Ligthart, P., van Rhenen, D., Schepers, H., de Haas, M. & van der Schoot, C. E., jun.-2015, In: Transfusion. 55, 6, blz. 1457-1466 10 blz.

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22 Citaten (Scopus)

2014

The TAK1-NF-κB axis as therapeutic target for AML

Bosman, M. C. J., Schepers, H., Jaques, J., Vos, A., Quax, W. J., Schuringa, J. J. & Vellenga, E., 13-nov.-2014, In: Blood. 124, 20, blz. 3130-3140 11 blz.

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52 Citaten (Scopus)

2013

SMIM1 underlies the Vel blood group and influences red blood cell traits

Cvejic, A., Haer-Wigman, L., Stephens, J. C., Kostadima, M., Smethurst, P. A., Frontini, M., van den Akker, E., Bertone, P., Bielczyk-Maczynska, E., Farrow, S., Fehrmann, R. S. N., Gray, A., de Haas, M., Haver, V. G., Jordan, G., Karjalainen, J., Kerstens, H. H. D., Kiddle, G., Lloyd-Jones, H. & Needs, M. & 22 anderen, Poole, J., Soussan, A. A., Rendon, A., Rieneck, K., Sambrook, J. G., Schepers, H., Sillje, H. H. W., Sipos, B., Swinkels, D., Tamuri, A. U., Verweij, N., Watkins, N. A., Westra, H.-J., Stemple, D., Franke, L., Soranzo, N., Stunnenberg, H. G., Goldman, N., van der Harst, P., van der Schoot, C. E., Ouwehand, W. H. & Albers, C. A., mei-2013, In: Nature Genetics. 45, 5, blz. 542-545 4 blz.

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86 Citaten (Scopus)

2012

Seventy-five genetic loci influencing the human red blood cell

van der Harst, P., Zhang, W., Mateo Leach, I., Rendon, A., Verweij, N., Sehmi, J., Paul, D. S., Elling, U., Allayee, H., Li, X., Radhakrishnan, A., Tan, S.-T., Voss, K., Weichenberger, C. X., Albers, C. A., Al-Hussani, A., Asselbergs, F. W., Ciullo, M., Danjou, F. & Dina, C. & 175 anderen, Esko, T., Evans, D. M., Franke, L., Gögele, M., Hartiala, J., Hersch, M., Holm, H., Hottenga, J.-J., Kanoni, S., Kleber, M. E., Lagou, V., Langenberg, C., Lopez, L. M., Lyytikäinen, L.-P., Melander, O., Murgia, F., Nolte, I. M., O'Reilly, P. F., Padmanabhan, S., Parsa, A., Pirastu, N., Porcu, E., Portas, L., Prokopenko, I., Ried, J. S., Shin, S.-Y., Tang, C. S., Teumer, A., Traglia, M., Ulivi, S., Westra, H.-J., Yang, J., Zhao, J. H., Anni, F., Abdellaoui, A., Attwood, A., Balkau, B., Bandinelli, S., Bastardot, F., Benyamin, B., Boehm, B. O., Cookson, W. O., Das, D., de Bakker, P. I. W., de Boer, R. A., de Geus, E. J. C., de Moor, M. H., Dimitriou, M., Domingues, F. S., Döring, A., Engström, G., Eyjolfsson, G. I., Ferrucci, L., Fischer, K., Galanello, R., Garner, S. F., Genser, B., Gibson, Q. D., Girotto, G., Gudbjartsson, D. F., Harris, S. E., Hartikainen, A.-L., Hastie, C. E., Hedblad, B., Illig, T., Jolley, J., Kähönen, M., Kema, I. P., Kemp, J. P., Liang, L., Lloyd-Jones, H., Loos, R. J. F., Meacham, S., Medland, S. E., Meisinger, C., Memari, Y., Mihailov, E., Miller, K., Moffatt, M. F., Nauck, M., Novatchkova, M., Nutile, T., Olafsson, I., Onundarson, P. T., Parracciani, D., Penninx, B. W., Perseu, L., Piga, A., Pistis, G., Pouta, A., Puc, U., Raitakari, O., Ring, S. M., Robino, A., Ruggiero, D., Ruokonen, A., Saint-Pierre, A., Sala, C., Salumets, A., Sambrook, J., Schepers, H., Schmidt, C. O., Silljé, H. H. W., Sladek, R., Smit, J. H., Starr, J. M., Stephens, J., Sulem, P., Tanaka, T., Thorsteinsdottir, U., Tragante, V., van Gilst, W. H., van Pelt, L. J., van Veldhuisen, D. J., Völker, U., Whitfield, J. B., Willemsen, G., Winkelmann, B. R., Wirnsberger, G., Algra, A., Cucca, F., d'Adamo, A. P., Danesh, J., Deary, I. J., Dominiczak, A. F., Elliott, P., Fortina, P., Froguel, P., Gasparini, P., Greinacher, A., Hazen, S. L., Jarvelin, M.-R., Khaw, K. T., Lehtimäki, T., Maerz, W., Martin, N. G., Metspalu, A., Mitchell, B. D., Montgomery, G. W., Moore, C., Navis, G., Pirastu, M., Pramstaller, P. P., Ramirez-Solis, R., Schadt, E., Scott, J., Shuldiner, A. R., Smith, G. D., Smith, J. G., Snieder, H., Sorice, R., Spector, T. D., Stefansson, K., Stumvoll, M., Tang, W. H. W., Toniolo, D., Tönjes, A., Visscher, P. M., Vollenweider, P., Wareham, N. J., Wolffenbuttel, B. H. R., Boomsma, D. I., Beckmann, J. S., Dedoussis, G. V., Deloukas, P., Ferreira, M. A., Sanna, S., Uda, M., Hicks, A. A., Penninger, J. M., Gieger, C., Kooner, J. S., Ouwehand, W. H., Soranzo, N. & Chambers, J. C., 20-dec.-2012, In: Nature. 492, 7429, blz. 369-375 7 blz.

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259 Citaten (Scopus)

208 Downloads (Pure)

2009

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells

Kranc, K. R., Schepers, H., Rodrigues, N. P., Bamforth, S., Villadsen, E., Ferry, H., Bouriez-Jones, T., Sigvardsson, M., Bhattacharya, S., Jacobsen, S. E. & Enver, T., 4-dec.-2009, In: Cell stem cell. 5, 6, blz. 659-665 7 blz.

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95 Citaten (Scopus)

125 Downloads (Pure)

2008

Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases

Fatrai, S., Schepers, H., Tadema, H., Vellenga, E., Daenen, S. M. G. J. & Schuringa, J. J., okt.-2008, In: Experimental Hematology. 36, 10, blz. 1254-1265 12 blz.

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36 Citaten (Scopus)

2007

Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells

van Gosliga, D., Schepers, H., Rizo, A., van der Kolk, D., Vellenga, E. & Schuringa, J. J., okt.-2007, In: Experimental Hematology. 35, 10, blz. 1538-1549 12 blz.

Onderzoeksoutput › Academic › peer review

78 Citaten (Scopus)

Reintroduction of C/EBP alpha in leukemic CD34(+) stem/progenitor cells impairs self-renewal and partially restores myelopoiesis

Schepers, H., Wierenga, A. T. J., van Gosliga, D., Eggen, B. J. L., Vellenga, E. & Schuringa, J. J., 15-aug.-2007, In: Blood. 110, 4, blz. 1317-1325 9 blz.

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42 Citaten (Scopus)

492 Downloads (Pure)

STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells

Schepers, H., van Gosliga, D., Wierenga, A. T. J., Eggen, B. J. L., Schuringa, J. J. & Vellenga, E., 15-okt.-2007, In: Blood. 110, 8, blz. 2880-2888 9 blz.

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88 Citaten (Scopus)

885 Downloads (Pure)

2006

Cellular effects of imatinib on medullary thyroid cancer cells, harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations

de Groot, J. W. B., Menacho, I. P., Schepers, H., Drenth-Diephuis, L. J., Osinga, J., Plukker, J. T., Links, T. P., Eggen, B. J. L. & Hofstra, R. M. W., 2006, In: Surgery. 139, 6, blz. 806 - 814 9 blz.

Onderzoeksoutput › Academic › peer review

59 Citaten (Scopus)

320 Downloads (Pure)