Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
- 50 - 78 van 78 resultaten
Zoekresultaten
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2012
The role of metabolism in Diclofenac-induced intestinal toxicity in human ex vivo
Niu, X., Makkinje, M., de Graaf, I. & Groothuis, G., 2012, In: ISSX Online Abstracts. Supplement 7, 1, 1 blz.Onderzoeksoutput: Meeting Abstract › Academic
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The role of metabolism in diclofenac-induced intestinal toxicity in rat and human in vitro
Niu, X., Makkinje, M., de Graaf, I. & Groothuis, G., mrt.-2012, In: The Toxicologist. Supplement to Toxicological Sciences. 126, 1, blz. 393-392 1 blz.Onderzoeksoutput: Meeting Abstract › Academic
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Transport of the Coumarin Metabolite 7-Hydroxycoumarin Glucuronide Is Mediated via Multidrug Resistance-Associated Proteins 3 and 4
Wittgen, H. G. M., van den Heuvel, J. J. M. W., van den Broek, P. H. H., Siissalo, S., Groothuis, G. M. M., de Graaf, I. A. M., Koenderink, J. B. & Russel, F. G. M., jun.-2012, In: Drug Metabolism and Disposition. 40, 6, blz. 1076-1079 4 blz.Onderzoeksoutput: Article › Academic › peer review
16 Citaten (Scopus) -
2011
On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices
van Midwoud, P. M., Janssen, J., Merema, M. T., de Graaf, I. A. M., Groothuis, G. M. M. & Verpoorte, E., 1-jan.-2011, In: Analytical Chemistry. 83, 1, blz. 84-91 8 blz.Onderzoeksoutput: Article › Academic › peer review
38 Citaten (Scopus) -
Promoting physical activity in children with juvenile idiopathic arthritis through an internet-based program: Results of a pilot randomised controlled trial
Lelieveld, O., Armbrust, W., Geertzen, J., De Graaf, I., Van Leeuwen, M., Sauer, P., Van Weert, E. & Bouma, J., 1-jun.-2011, In: Physiotherapy. 97, Suppliment 1, blz. aS680-681Onderzoeksoutput: Meeting Abstract › Academic
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2010
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
de Graaf, I. A. M., Olinga, P., de Jager, M. H., Merema, M. T., de Kanter, R., van de Kerkhof, E. G. & Groothuis, G. M. M., sep.-2010, In: Nature protocols. 5, 9, blz. 1540-1551 12 blz.Onderzoeksoutput: Article › Academic › peer review
Open AccessBestand328 Citaten (Scopus)445 Downloads (Pure) -
Reduced Ischemia-Reoxygenation Injury in Rat Intestine After Luminal Preservation With a Tailored Solution
Roskott, A. M., Nieuwenhuijs, V. B., Leuvenink, H. G. D., Dijkstra, G., Ottens, P., de Jager, M. H., Pereira, P. G. D., Fidler, V., Groothuis, G. M. M., Ploeg, R. J. & de Graaf, I. A. M., 27-sep.-2010, In: Transplantation. 90, 6, blz. 622-629 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand20 Citaten (Scopus)651 Downloads (Pure) -
Selection of low toxicity cryoprotectant solutions for investigating the basic mechanism of chilling injury in precision-cut rat liver slices
Guan, N., Blomsma, S., van Midwoud, P., Fahy, G. M., Groothuis, G. & de Graaf, I., dec.-2010, In: Cryobiology. 61, 3, blz. 369-370 2 blz.Onderzoeksoutput: Meeting Abstract › Academic
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Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro - A quantitative study
Asgeirsdottir, S. A., Talman, E. G., de Graaf, I. A., Kamps, J. A. A. M., Satchell, S. C., Mathieson, P. W., Ruiters, M. H. J. & Molema, G., 25-jan.-2010, In: Journal of Controlled Release. 141, 2, blz. 241-251 11 blz.Onderzoeksoutput: Article › Academic › peer review
33 Citaten (Scopus) -
2009
Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function
van Meurs, M., Kurniati, N. F., Wulfert, F. M., Asgeirsdottir, S. A., de Graaf, I. A., Satchell, S. C., Mathieson, P. W., Jongman, R. M., Kuempers, P., Zijlstra, J. G., Heeringa, P. & Molema, G., aug.-2009, In: American journal of physiology-Renal physiology. 297, 2, blz. F272-F281 10 blz.Onderzoeksoutput › Academic › peer review
54 Citaten (Scopus) -
2008
Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro
van de Kerkhof, E., De Graaf, I. A. M., Ungell, A.-L. B. & Groothuis, G. M. M., mrt.-2008, In: Drug Metabolism and Disposition. 36, 3, blz. 604-613 10 blz.Onderzoeksoutput › Academic › peer review
75 Citaten (Scopus) -
2007
Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification
de Graaf, I. A. M., Draaisma, A. L., Schoeman, O., Fahy, G. M., Groothuis, G. M. M. & Koster, H. J., feb.-2007, In: Cryobiology. 54, 1, blz. 1-12 12 blz.Onderzoeksoutput › Academic › peer review
56 Citaten (Scopus) -
Induction of phase I and II drug metabolism in rat small intestine and colon in vitro
van de Kerkhof, E. G., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., jun.-2007, In: Drug Metabolism and Disposition. 35, 6, blz. 898-907 10 blz.Onderzoeksoutput: Article › Academic › peer review
34 Citaten (Scopus) -
In vitro methods to study intestinal drug metabolism
van de Kerkhof, E. G., de Graaf, I. A. M. & Groothuis, G. M. M., okt.-2007, In: Current drug metabolism. 8, 7, blz. 658-675 18 blz.Onderzoeksoutput › peer review
119 Citaten (Scopus) -
Precision-cut tissue slices as a tool to predict metabolism of novel drugs
de Graaf, I. A. M., Groothuis, G. M. M. & Olinga, P., dec.-2007, In: Expert Opinion on Drug Metabolism & Toxicology. 3, 6, blz. 879-898 20 blz.Onderzoeksoutput: Review article › peer review
118 Citaten (Scopus) -
2006
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction
de Graaf, I., de Kanter, R., de Jager, M., Camacho, R., Langenkamp, E., van de Kerkhof, E. & Groothuis, G., apr.-2006, In: Drug Metabolism and Disposition. 34, 4, blz. 591-599 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand42 Citaten (Scopus)122 Downloads (Pure) -
Innovative methods to study human intestinal drug metabolism in vitro: Precision-cut slices compared with Ussing chamber preparations
van de Kerkhof, E. G., Ungell, A.-L. B., Sjoberg, A. K., de Jager, M. H., Hilgendorf, C., de Graaf, I. A. M. & Groothuis, G. M. M., nov.-2006, In: Drug Metabolism and Disposition. 34, 11, blz. 1893-1902 10 blz.Onderzoeksoutput › Academic › peer review
91 Citaten (Scopus) -
2005
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies
de Kanter, R., Tuin, A., van de Kerkhof, E. G., Martignoni, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Meijer, D. K. F. & Groothuis, G., 2005, In: Journal of Pharmacological and Toxicological Methods. 51, 1, blz. 65 - 72 8 blz.Onderzoeksoutput › Academic › peer review
50 Citaten (Scopus) -
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies
van de Kerkhof, E., de Graaf, I., de Jager, M., Meijer, D. & Groothuis, G., nov.-2005, In: Drug Metabolism and Disposition. 33, 11, blz. 1613-1620 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand52 Citaten (Scopus)157 Downloads (Pure) -
2004
Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon
de Kanter, R., Monshouwer, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Proost, J. H., Meijer, D. K. F. & Groothuis, G., 2004, In: Xenobiotica. 34, 3, blz. 229-241 13 blz.Onderzoeksoutput › Academic › peer review
53 Citaten (Scopus) -
2003
Cryopreservation of precision-cut tissue slices for application in drug metabolism research
de Graaf, I. A. M. & Koster, H., feb.-2003, In: Toxicol.In Vitro. 17, 1, blz. 1-17 17 blz.Onderzoeksoutput: Article › Academic › peer review
32 Citaten (Scopus) -
2002
Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism
De Graaf, I. A. M., Van Meijeren, C. E., Pektaş, F. & Koster, H. J., okt.-2002, In: Drug Metabolism and Disposition. 30, 10, blz. 1129-36 8 blz.Onderzoeksoutput › Academic › peer review
45 Citaten (Scopus) -
Incubation at 37 degrees C prior to cryopreservation decreases viability of liver slices after cryopreservation by rapid freezing
de Graaf, I. A. M., Geerlinks, A. & Koster, H. J., aug.-2002, In: Cryobiology. 45, 1, blz. 1-9 9 blz.Onderzoeksoutput › Academic › peer review
5 Citaten (Scopus) -
2001
Water crystallization within rat precision-cut liver slices in relation to their viability
de Graaf, I. A. & Koster, H. J., nov.-2001, In: Cryobiology. 43, 3, blz. 224-37 14 blz.Onderzoeksoutput › Academic › peer review
15 Citaten (Scopus) -
2000
Assessment of some critical factors in the freezing technique for the cryopreservation of precision-cut rat liver slices
Maas, W. J. M., de Graaf, I. A., Schoen, E. D., Koster, H. J., van de Sandt, J. J. & Groten, J. P., mei-2000, In: Cryobiology. 40, 3, blz. 250-263 14 blz.Onderzoeksoutput › Academic › peer review
36 Citaten (Scopus) -
Increased post-thaw viability and phase I and II biotransformation activity in cryopreserved rat liver slices after improvement of a fast-freezing method
de Graaf, I. A. M., van der Voort, D., Brits, J. H. & Koster, H. J., sep.-2000, In: Drug Metabolism and Disposition. 28, 9, blz. 1100-6 7 blz.Onderzoeksoutput › Academic › peer review
37 Citaten (Scopus) -
Intercellular communication and cell proliferation in precision-cut rat liver slices: effect of medium composition and DDT
de Graaf, I. A., Tajima, O., Groten, J. P. & Wolterbeek, A. P., 1-jun.-2000, In: Cancer letters. 154, 1, blz. 53-62 10 blz.Onderzoeksoutput › Academic › peer review
7 Citaten (Scopus) -
1996
Paraquat Exposure of Knapsack Spray Operators on Banana Plantations in Costa Rica
van Wendel de Joode, B. N., Wesseling, B., de Graaf, I. & Kromhout, S. B., okt.-1996, In: International Journal of Occupational and Environmental Health. 2, 4, blz. 294-304 11 blz.Onderzoeksoutput › Academic › peer review
44 Citaten (Scopus)