Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
- 1 - 50 van 68 resultaten
Zoekresultaten
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2024
Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering
Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., apr.-2024, In: Peptides. 174, 26 blz., 171152.Onderzoeksoutput › Academic › peer review
Open AccessBestand3 Citaten (Scopus)119 Downloads (Pure) -
An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains.
Guo, L., Kuipers, O. P. & Broos, J., 20-sep.-2024, In: ACS chemical biology. 19, 9, blz. 2023-2031 9 blz., 4c00337.Onderzoeksoutput › Academic › peer review
Open AccessBestand12 Downloads (Pure) -
Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V
Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., mei-2024, In: Microbiological Research. 282, 11 blz., 127640.Onderzoeksoutput › Academic › peer review
Open AccessBestand3 Citaten (Scopus)63 Downloads (Pure) -
Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity
Guo, L., Kuipers, O. P. & Broos, J., 28-jun.-2024, In: Journal of Natural Products. 87, 6, blz. 1548-1555 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand1 Citaat (Scopus)13 Downloads (Pure) -
Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains.
Guo, L., Wambui, J., Wang, C., Broos, J., Stephan, R. & Kuipers, O. P., 19-jan.-2024, In: ACS Synthetic Biology. 13, 1, blz. 370–383 15 blz., 3c00612.Onderzoeksoutput › Academic › peer review
Open AccessBestand6 Citaten (Scopus)45 Downloads (Pure) -
2023
Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles
Guo, L., Wambui, J., Wang, C., Muchaamba, F., Fernandez-Cantos, M. V., Broos, J., Tasara, T., Kuipers, O. P. & Stephan, R., okt.-2023, In: Microbiology Spectrum. 11, 5, 21 blz., e0531922.Onderzoeksoutput › Academic › peer review
Open AccessBestand8 Citaten (Scopus)72 Downloads (Pure) -
Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity
Guo, L., Wang, C., Broos, J. & Kuipers, O. P., jul.-2023, In: The Journal of Biological Chemistry. 229, 7, 12 blz., 104845.Onderzoeksoutput › Academic › peer review
Open AccessBestand14 Citaten (Scopus)100 Downloads (Pure) -
2022
Probing the Conformational States of Thimet Oligopeptidase in Solution
Marcondes, M. F. M., Santos, G. S., Bronze, F., Machado, M. F. M., Perez, K. R., Hesselink, R., de Vries, M. P., Broos, J. & Oliveira, V., 1-jul.-2022, In: International Journal of Molecular Sciences. 23, 13, 18 blz., 7297.Onderzoeksoutput › Academic › peer review
Open AccessBestand52 Downloads (Pure) -
The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach
Shao, J., Kuiper, B. P., Thunnissen, A.-M. W. H., Cool, R. H., Zhou, L., Huang, C., Dijkstra, B. W. & Broos, J., sep.-2022, In: Journal of the American Chemical Society. 144, 30, blz. 13815-13822 8 blz., 04986.Onderzoeksoutput › Academic › peer review
Open AccessBestand45 Citaten (Scopus)183 Downloads (Pure) -
2018
Cyano-tryptophans as dual infrared and fluorescence spectroscopic labels to assess structural dynamics in proteins
van Wilderen, L. J. G. W., Brunst, H., Gustmann, H., Wachtveitl, J., Broos, J. & Bredenbeck, J., 2018, In: PPCP : Physical Chemistry Chemical Physics. 20, 30, blz. 19906-19915 C8CP00846A.Onderzoeksoutput › Academic › peer review
Open AccessBestand28 Citaten (Scopus)95 Downloads (Pure) -
2017
On the efficient bio-incorporation of 5-hydroxy-tryptophan in recombinant proteins expressed in Escherichia coli with T7 RNA polymerase-based vectors
Oliveira-Souza, W. P., Bronze, F., Broos, J., Marcondes, M. F. M. & Oliveira, V., 21-okt.-2017, In: Biochemical and Biophysical Research Communications. 492, 3, blz. 343-348 6 blz., j.bbrc.2017.08.111.Onderzoeksoutput › Academic › peer review
Open AccessBestand2 Citaten (Scopus)96 Downloads (Pure) -
2016
Development of Chemically Defined Media to Express Trp-Analog-Labeled Proteins in a Lactococcus lactis Trp Auxotroph
Shao, J., Marcondes, M. F. M., Oliveira, V. & Broos, J., 2016, In: Journal of Molecular Microbiology and Biotechnology. 26, 4, blz. 269-276 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand1 Citaat (Scopus)245 Downloads (Pure) -
Incorporation of tryptophan analogues into the lantibiotic nisin
Zhou, L., Shao, J., Li, Q., van Heel, A. J., de Vries, M. P., Broos, J. & Kuipers, O. P., mei-2016, In: Amino Acids. 48, 5, blz. 1309-1318 10 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand37 Citaten (Scopus)327 Downloads (Pure) -
2015
Biosynthetic incorporation of the azulene moiety in proteins with high efficiency
Shao, J., Korendovych, I. V. & Broos, J., jan.-2015, In: Amino Acids. 47, 1, blz. 213-216 4 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand16 Citaten (Scopus)67 Downloads (Pure) -
Picosecond Fluorescence Dynamics of Tryptophan and 5-Fluorotryptophan in Monellin: Slow Water-Protein Relaxation Unmasked
Xu, J., Chen, B., Callis, P. R., Muiño, P. L., Rozeboom, H. J., Broos, J., Toptygin, D., Brand, L. & Knutson, J. R., 24-feb.-2015, In: The Journal of Physical Chemistry. B: Materials, Surfaces, Interfaces, & Biophysical. 119, 11, blz. 4230-4239 10 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand18 Citaten (Scopus)64 Downloads (Pure) -
2014
Biosynthetic Incorporation of Tryptophan Analogs in Proteins
Broos, J., 2014, In: Methods in Molecular Biology. 1076, blz. 359-370 12 blz.Onderzoeksoutput › Academic › peer review
12 Citaten (Scopus) -
Isolation of Escherichia coli Mannitol Permease, EIImtl, Trapped in Amphipol A8-35 and Fluorescein-Labeled A8-35
Opacic, M., Giusti, F., Popot, J.-L. & Broos, J., okt.-2014, In: Journal of membrane biology. 247, 9-10, blz. 1019-1030 12 blz.Onderzoeksoutput › Academic › peer review
2 Citaten (Scopus) -
2013
An expression system for the efficient incorporation of an expanded set of tryptophan analogues
Petrovic, D. M., Leenhouts, K., van Roosmalen, M. L. & Broos, J., mei-2013, In: Amino Acids. 44, 5, blz. 1329-1336 8 blz.Onderzoeksoutput › Academic › peer review
17 Citaten (Scopus)46 Downloads (Pure) -
Emitting State of 5‑Hydroxyindole, 5‑Hydroxytryptophan, and 5‑Hydroxytryptophan Incorporated in Proteins
Petrovic, D. M., Hesp, B. H. & Broos, J., 19-sep.-2013, In: The Journal of Physical Chemistry B. 117, 37, blz. 10792-10797 6 blz.Onderzoeksoutput › Academic › peer review
6 Citaten (Scopus)1 Downloads (Pure) -
Femtosecond Fluorescence Dynamics of Tryptophan and 5-Fluorotryptophan in Monellin: Slow Water Relaxation Unmasked
Xu, J., Chen, B., Callis, P., Rozeboom, H., Broos, J. & Knutson, J., 29-jan.-2013, In: Biophysical Journal. 104, 2, blz. 681a-681a 1 blz.Onderzoeksoutput › Academic
Open AccessBestand285 Downloads (Pure) -
2012
Chloro- and Bromo-Tryptophan Analogs as Phosphorescent Probes in Proteins
Broos, J., Petrovic, D. M., Leenhouts, K., Roosmalen, M. L. V., Gonelli, M. & Strambini, G. B., 31-jan.-2012, In: Biophysical Journal. 102, 3, blz. 209a-209a 1 blz.Onderzoeksoutput › Academic
Open AccessBestand283 Downloads (Pure) -
Monitoring lysin motif-ligand interactions via tryptophan analog fluorescence spectroscopy
Petrovic, D. M., Leenhouts, K., van Roosmalen, M. L., KleinJan, F. & Broos, J., 15-sep.-2012, In: Analytical Biochemistry. 428, 2, blz. 111-118 8 blz.Onderzoeksoutput › Academic › peer review
15 Citaten (Scopus)53 Downloads (Pure) -
Structural investigation of the transmembrane C domain of the mannitol permease from Escherichia coli using 5-FTrp fluorescence spectroscopy
Opacic, M., Hesp, B. H., Fusetti, F., Dijkstra, B. & Broos, J., mrt.-2012, In: Biochimica et Biophysica Acta-Biomembranes. 1818, 3, blz. 861-868 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand8 Citaten (Scopus)475 Downloads (Pure) -
2011
5-Fluorotryptophan as Fluorescent Probe to Characterize an Oligomeric Membrane Protein
Broos, J., 2011, In: Biophysical Journal. 100, 3, blz. 609a-609aOnderzoeksoutput › Academic
Open AccessBestand271 Downloads (Pure) -
2010
Localization of the substrate binding site in the homodimeric mannitol transporter, EIImtl, of Escherichia coli
Opacic, M., Vos, E. P. P., Hesp, B. H. & Broos, J., 13-aug.-2010, In: The Journal of Biological Chemistry. 285, 33, blz. 25324-25331 8 blz.Onderzoeksoutput › Academic › peer review
12 Citaten (Scopus) -
2009
5-Fluorotryptophan as dual probe for ground-state heterogeneity and excited-state dynamics in apoflavodoxin
Visser, N. V., Westphal, A. H., Nabuurs, S. M., van Hoek, A., Mierlo, C. P. M. V., Visser, A. J. W. G., Broos, J. & van Amerongen, H., 3-sep.-2009, In: FEBS Letters. 583, 17, blz. 2785-2788 4 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand14 Citaten (Scopus)479 Downloads (Pure) -
Domain complementation studies reveal residues critical for the activity of the mannitol permease from Escherichia coli
Vos, E. P. P., ter Horst, R., Poolman, B. & Broos, J., feb.-2009, In: Biochimica et Biophysica Acta-Biomembranes. 1788, 2, blz. 581-586 6 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand6 Citaten (Scopus)306 Downloads (Pure) -
Structure of the Cytoplasmic Loop between Putative Helices II and III of the Mannitol Permease of Escherichia coli: A Tryptophan and 5-Fluorotryptophan Spectroscopy Study
Vos, E. P. P., Bokhove, M., Hesp, B. H. & Broos, J., 16-jun.-2009, In: Biochemistry. 48, 23, blz. 5284-5290 7 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand6 Citaten (Scopus)345 Downloads (Pure) -
2008
Domain complementation studies reveal residues critical for the activity of the mannitol permease from Escherichia coli
Vos, E. P., ter Horst, R. & Broos, J., 2008, In: Biochimica et Biophysica Acta.Onderzoeksoutput › Academic › peer review
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Lactococcus lactis as expression host for the biosynthetic incorporation of tryptophan analogues into recombinant proteins
El Khattabi, M., van Roosmalen, M. L., Jager, D., Metselaar, H., Permentier, H., Leenhouts, K. & Broos, J., 2008, In: Biochemical Journal. 409, 1, blz. 193-198 6 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand14 Citaten (Scopus)431 Downloads (Pure) -
Mutations in transhydrogenase change the fluorescence emission state of TRP72 from L-1(a) to L-1(b)
Jensen, K. T., Strambini, G., Gonnelli, M., Broos, J. & Jackson, J. B., 1-okt.-2008, In: Biophysical Journal. 95, 7, blz. 3419-3428 10 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand7 Citaten (Scopus)364 Downloads (Pure) -
2007
Tagging multiphoton ionization events by two-dimensional photoelectron spectroscopy
de Groot, M., Broos, J. & Buma, W. J., 28-mei-2007, In: Journal of Chemical Physics. 126, 20, blz. 204312 - 204312 1 blz., 204312.Onderzoeksoutput › Academic › peer review
Open AccessBestand5 Citaten (Scopus)373 Downloads (Pure) -
The emitting state of tryptophan in proteins with highly blue-shifted fluorescence
Broos, J., Tveen-Jensen, K., de Waal, E., Hesp, B. H., Jackson, J. B., Canters, G. W. & Callis, P. R., 2007, In: Angewandte Chemie-International Edition. 46, 27, blz. 5137-5139 3 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand33 Citaten (Scopus)700 Downloads (Pure) -
2006
Intra-domain and inter-domain motions in proton-translocating transhydrogenase
Jensen, K. T., Jackson, J. B., Broos, J. & Strambini, G. B., 2006, In: Biochimica et Biophysica Acta-Bioenergetics. blz. 244 - 244 1 blz.Onderzoeksoutput › Academic › peer review
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Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri
Hamiaux, C., Eerde, A. V., Parsot, C., Broos, J. & Dijkstra, B. W., 2006, In: Embo Reports. 62, 11, blz. 794-799 6 blz.Onderzoeksoutput › Academic
24 Citaten (Scopus) -
The oligomeric state and stability of the mannitol transporter, EnzymeII(mtl), from Escherichia coli: A fluorescence correlation spectroscopy study
Veldhuis, G., Hink, M., Krasnikov, V., Van Den Bogaart, G., Hoeboer, J., Visser, A. J. W. G., Broos, J. & Poolman, B., aug.-2006, In: Protein Science. 15, 8, blz. 1977-1986 10 blz.Onderzoeksoutput › Academic › peer review
5 Citaten (Scopus) -
2005
Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins
Liu, T., Callis, P., Hesp, B., de Groot, M., Buma, W., Broos, J., Liu, T., Callis, P. R. & Buma, W. J., 23-mrt.-2005, In: Journal of the American Chemical Society. 127, 11, blz. 4104-4113 10 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand81 Citaten (Scopus)618 Downloads (Pure) -
Merging homogeneous catalysis with biocatalysis: papain as hydrogenation catalyst
Panella, L., Broos, J., Jin, J., Fraaije, M. W., Janssen, D. B., Jeronimus-Stratingh, C., Feringa, B. L., Minnaard, A. J. & Vries, J. G. D., 2005, In: Chemical Communications. 103, 45, blz. 5656-5658 3 blz.Onderzoeksoutput › Academic › peer review
83 Citaten (Scopus) -
Stoichiometry and Substrate Affinity of the Mannitol Transporter, EnzymeIImtl, from Escherichia coli
Veldhuis, G., Broos, J., Poolman, B. & Scheek, R. M., 2005, In: Biophysical Journal. 89, 1, blz. 201 - 210 10 blz.Onderzoeksoutput › Academic
Open AccessBestand12 Citaten (Scopus)279 Downloads (Pure) -
Substrate-induced Conformational Changes in the Membrane-embedded IICmtl-domain of the Mannitol Permease from Escherichia coli, EnzymeIImtl, Probed by Tryptophan Phosphorescence Spectroscopy
Veldhuis, G., Gabellieri, E., Poolman, B., Strambini, G. B. & Broos, J., 2005, In: The Journal of Biological Chemistry. 280, 42, blz. 35148 - 35156 9 blz.Onderzoeksoutput › Academic
Open AccessBestand17 Citaten (Scopus)253 Downloads (Pure) -
The first cytoplasmic loop of the mannitol permease from Escherichia coli is accessible for sulfhydryl reagents from the periplasmic side of the membrane
Vervoort, E. B., Bultema, J. B., Schuurman-Wolters, G. K., Geertsma, E. R., Broos, J. & Poolman, B., 2005, In: Journal of Molecular Biology. 346, 3, blz. 733 - 743 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand21 Citaten (Scopus)344 Downloads (Pure) -
2004
Evaluation of the flow-dialysis technique for analysis of protein-ligand interactions: An experimental and a Monte Carlo study
Veldhuis, G., Broos, J., Poolman, B. & Scheek, R., apr.-2004, In: Biophysical Journal. 86, 4, blz. 1959-1968 10 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand13 Citaten (Scopus)279 Downloads (Pure) -
In vivo synthesized proteins with monoexponential fluorescence decay kinetics
Broos, J., Maddalena, F. & Hesp, B., 14-jan.-2004, In: Journal of the American Chemical Society. 126, 1, blz. 22-23 2 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand28 Citaten (Scopus)502 Downloads (Pure) -
2003
Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein
Broos, J., Gabellieri, E., Biemans-Oldehinkel, E. & Strambini, G. B., sep.-2003, In: Protein Science. 12, 9, blz. 1991-2000 10 blz.Onderzoeksoutput › Academic › peer review
30 Citaten (Scopus)44 Downloads (Pure) -
Tryptophan phosphorescence spectroscopy reveals that a domain in the NAD(H)-binding component (dI) of transhydrogenase from Rhodospirillum rubrum has an extremely rigid and conformationally homogeneous protein core
Broos, J., Gabellieri, E., van Boxel, G., Jackson, J., Strambini, G. & Strambini, G. B., 28-nov.-2003, In: The Journal of Biological Chemistry. 278, 48, blz. 47578-47584 7 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand15 Citaten (Scopus)215 Downloads (Pure) -
2002
Impact of the enzyme flexibility on the enzyme enantio- selectivity in organic media towards specific and non-specific substrates
Broos, J., 2002, In: Biocatalysis and Biotransformation. 20, 4, blz. 291 - 295 5 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand18 Citaten (Scopus)348 Downloads (Pure) -
The smallest resonance energy transfer acceptor for tryptophan
Broos, J., Pas, H. & Robillard, G., 19-jun.-2002, In: Journal of the American Chemical Society. 124, 24, blz. 6812-6813 2 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand11 Citaten (Scopus)348 Downloads (Pure) -
2001
Mapping of the dimer interface of the Escherichia coli mannitol permease by cysteine cross-linking
van Montfort, B. A., Schuurman-Wolters, G. K., Wind, J., Broos, J., Robillard, G. T. & Poolman, B., 2001, In: The Journal of Biological Chemistry. 277, 17, blz. 14717 - 14723 7 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand24 Citaten (Scopus)221 Downloads (Pure) -
Studying membrane transport protein dynamics with tryptophan phosphorescence specroscopy
Broos, J., Strambini, G. B., Gonnelli, M., Wolters, G. S., Robillard, G. T. & Gonelli, M., 2001, In: Biophysical Journal. 80, 1, blz. 1050 1 blz.Onderzoeksoutput › Academic › peer review
253 Citaten (Scopus) -
2000
Membrane protein-ligand interactions in E-coli vesicles and living cells monitored via a biosynthetically incorporated tryptophan analog
Broos, J., ter Veld, F. & Robillard, G. T., 2000, In: Biophysical Journal. 78, 1, blz. 949Pos 1 blz.Onderzoeksoutput › Academic › peer review