Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
- 26 resultaten
Zoekresultaten
-
2024
Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation
Song, S., van Dijk, F., Vasse, G. F., Liu, Q., Gosselink, I. F., Weltjens, E., Remels, A. H., de Jager, M. H., Bos, S., Li, C., Stoeger, T., Rehberg, M., Kutschke, D., van Eck, G., Wu, X., Willems, S. H., Boom, D., Kooter, I. M., Spierings, D. & Wardenaar, R. & 5 anderen, , 15-feb.-2024, In: American Journal of Respiratory and Critical Care Medicine. 209, 4, blz. 427 - 443 17 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand7 Citaten (Scopus)33 Downloads (Pure) -
Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
Putri, K. S. S., Adhyatmika, A., Boorsma, C. E., Habibie, H., Ruigrok, M. J. R., Heukels, P., Timens, W., de Jager, M. H., Hinrichs, W. L. J., Olinga, P. & Melgert, B. N., jun.-2024, In: Lung. 202, blz. 331–342 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand1 Downloads (Pure) -
2021
Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices
Vasse, G. F., Van Os, L., De Jager, M., Jonker, M. R., Borghuis, T., Van Den Toorn, L. T., Jellema, P., White, E. S., Van Rijn, P., Harmsen, M. C., Heijink, I. H., Melgert, B. N. & Burgess, J. K., 28-jul.-2021, In: Frontiers in Pharmacology. 12, 15 blz., 669037.Onderzoeksoutput › Academic › peer review
Open AccessBestand7 Citaten (Scopus)79 Downloads (Pure) -
2018
Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter
Li, M., Vokral, I., Evers, B., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., 30-aug.-2018, In: European Journal of Pharmaceutical Sciences. 121, blz. 65-73 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand9 Citaten (Scopus)101 Downloads (Pure) -
Regional Differences in Intestinal Drug Metabolism
Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., Mutsaers, H. A. & Olinga, P., dec.-2018, In: Drug Metabolism and Disposition. 46, 11, blz. 1879-1885Onderzoeksoutput › Academic › peer review
Open AccessBestand12 Citaten (Scopus)74 Downloads (Pure) -
2017
Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study
Estrada-Ortiz, N., Guarra, F., de Graaf, I. A. M., Marchetti, L., de Jager, M. H., Groothuis, G. M. M., Gabbiani, C. & Casini, A., 7-sep.-2017, In: ChemMedChem. 12, 17, blz. 1429-1435 7 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand46 Citaten (Scopus)75 Downloads (Pure) -
P-gp activity and inhibition in the different regions of human intestine ex vivo
Li, M., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., mrt.-2017, In: Biopharmaceutics & drug disposition. 38, 2, blz. 127-138 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand18 Citaten (Scopus)91 Downloads (Pure) -
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
Li, M., de Graaf, I. A. M., van de Steeg, E., de Jager, M. H. & Groothuis, G. M. M., apr.-2017, In: Toxicology in Vitro. 40, blz. 26-33 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand23 Citaten (Scopus)91 Downloads (Pure) -
2016
The Consequence of Drug–Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices
Li, M., de Graaf, I., Siissalo, S., de Jager, M., van Dam, A. & Groothuis, G., 1-mei-2016, In: Drug Metabolism and Disposition. 44, 5, blz. 683-691 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand16 Citaten (Scopus)66 Downloads (Pure) -
2015
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo
Li, M., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., aug.-2015, In: Toxicology in Vitro. 29, 5, blz. 1070-1078 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand16 Citaten (Scopus)54 Downloads (Pure) -
2014
Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Warmerdam, E., de Jager, M. H., Groothuis, G. M. M., Picquet, M. & Casini, A., 17-feb.-2014, In: Inorganic Chemistry. 53, 4, blz. 2296-2303 8 blz.Onderzoeksoutput › Academic › peer review
194 Citaten (Scopus) -
2013
Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine
Siissalo, S., De Waard, H., De Jager, M. H., Hayeshi, R., Frijlink, H. W., Hinrichs, W. L. J., Dinter-Heidorn, H., Van Dam, A., Proost, J. H., Groothuis, G. M. M. & De Graaf, I. A. M., aug.-2013, In: Drug Metabolism and Disposition. 41, 8, blz. 1557-1565 9 blz.Onderzoeksoutput › Academic › peer review
8 Citaten (Scopus) -
2010
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
de Graaf, I. A. M., Olinga, P., de Jager, M. H., Merema, M. T., de Kanter, R., van de Kerkhof, E. G. & Groothuis, G. M. M., sep.-2010, In: Nature protocols. 5, 9, blz. 1540-1551 12 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand311 Citaten (Scopus)216 Downloads (Pure) -
Reduced Ischemia-Reoxygenation Injury in Rat Intestine After Luminal Preservation With a Tailored Solution
Roskott, A. M., Nieuwenhuijs, V. B., Leuvenink, H. G. D., Dijkstra, G., Ottens, P., de Jager, M. H., Pereira, P. G. D., Fidler, V., Groothuis, G. M. M., Ploeg, R. J. & de Graaf, I. A. M., 27-sep.-2010, In: Transplantation. 90, 6, blz. 622-629 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand20 Citaten (Scopus)642 Downloads (Pure) -
2007
Induction of phase I and II drug metabolism in rat small intestine and colon in vitro
van de Kerkhof, E. G., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., jun.-2007, In: Drug Metabolism and Disposition. 35, 6, blz. 898-907 10 blz.Onderzoeksoutput: Article › Academic › peer review
34 Citaten (Scopus) -
2006
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction
de Graaf, I., de Kanter, R., de Jager, M., Camacho, R., Langenkamp, E., van de Kerkhof, E. & Groothuis, G., apr.-2006, In: Drug Metabolism and Disposition. 34, 4, blz. 591-599 9 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand42 Citaten (Scopus)90 Downloads (Pure) -
Innovative methods to study human intestinal drug metabolism in vitro: Precision-cut slices compared with Ussing chamber preparations
van de Kerkhof, E. G., Ungell, A.-L. B., Sjoberg, A. K., de Jager, M. H., Hilgendorf, C., de Graaf, I. A. M. & Groothuis, G. M. M., nov.-2006, In: Drug Metabolism and Disposition. 34, 11, blz. 1893-1902 10 blz.Onderzoeksoutput › Academic › peer review
89 Citaten (Scopus) -
2005
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies
de Kanter, R., Tuin, A., van de Kerkhof, E. G., Martignoni, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Meijer, D. K. F. & Groothuis, G., 2005, In: Journal of Pharmacological and Toxicological Methods. 51, 1, blz. 65 - 72 8 blz.Onderzoeksoutput: Article › Academic › peer review
49 Citaten (Scopus) -
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies
van de Kerkhof, E., de Graaf, I., de Jager, M., Meijer, D. & Groothuis, G., nov.-2005, In: Drug Metabolism and Disposition. 33, 11, blz. 1613-1620 8 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand52 Citaten (Scopus)113 Downloads (Pure) -
2004
Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon
de Kanter, R., Monshouwer, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Proost, J. H., Meijer, D. K. F. & Groothuis, G., 2004, In: Xenobiotica. 34, 3, blz. 229-241 13 blz.Onderzoeksoutput: Article › Academic › peer review
53 Citaten (Scopus) -
2002
Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices
De Kanter, R., De Jager, M., Draaisma, A., Jurva, J., Olinga, P., Meijer, D. & Groothuis, G., mei-2002, In: Xenobiotica. 32, 5, blz. 349-362 14 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand76 Citaten (Scopus)81 Downloads (Pure) -
2001
Rat liver slices as a tool to study LPS-induced inflammatory response in the liver
Olinga, P., Merema, M. T., de Jager, M. H., Derks, F., Melgert, B. N., Moshage, H., Slooff, M. J. H., Meijer, D. K. F., Poelstra, K. & Groothuis, G. M. M., aug.-2001, In: Journal of Hepatology. 35, 2, blz. 187-194 8 blz.Onderzoeksoutput › Academic › peer review
80 Citaten (Scopus) -
The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake
Olinga, P., Hof, I., Smit, M., de Jager, M., Swart, P., Slooff, M., Meijer, D., Groothuis, G. & Merema, M. T., 2001, In: Journal of Pharmacological and Toxicological Methods. 45, 1, blz. 55-63 9 blz.Onderzoeksoutput: Article › Academic › peer review
66 Citaten (Scopus) -
1999
Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney
Olinga, P., de Jager, M. H., Meijer, D. K. F., Groothuis, G. & Merema, M. T., 1999, In: Toxicology in Vitro. 13, 4-5, blz. 737 - 744 8 blz.Onderzoeksoutput: Article › Academic › peer review
58 Citaten (Scopus) -
1998
A rapid and simple method for cryopreservation of human liver slices
de Kanter, R., Olinga, P., Hof, I. H., de Jager, M. H., Verwillegen, W. A., Slooff, M. J., Meijer, D. K. F., Groothuis, G. & Koster, H., mrt.-1998, In: Xenobiotica. 28, 3, blz. 225-234 10 blz.Onderzoeksoutput › Academic › peer review
40 Citaten (Scopus) -
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver
Olinga, P., Hof, I. H., de Jager, M. H., de Jong, K., Slooff, M. J., Meijer, D. K. F., Groothuis, G. & Merema, M. T., apr.-1998, In: Xenobiotica. 28, 4, blz. 349 - 360 12 blz.Onderzoeksoutput › Academic › peer review
36 Citaten (Scopus)