Nicola Grzeschik

2022

Coenzyme A precursors flow from mother to zygote and from microbiome to host

Yu, Y., van der Zwaag, M., Wedman, J. J., Permentier, H., Plomp, N., Jia, X., Kanon, B., Eggens-Meijer, E., Buist, G., Harmsen, H., Kok, J., Salles, J. F., Wertheim, B., Hayflick, S. J., Strauss, E., Grzeschik, N. A., Schepers, H. & Sibon, O. C. M., 21-jul.-2022, In: Molecular Cell. 82, 14, blz. 2650-2665.e12 29 blz.

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12 Citaten (Scopus)

195 Downloads (Pure)

2021

Coenzyme A levels influence protein acetylation, CoAlation and 4'-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule

Yu, Y., Moretti, I. F., Grzeschik, N. A., Sibon, O. C. M. & Schepers, H., apr.-2021, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 4, 6 blz., 118965.

Onderzoeksoutput: Review article › peer review

Open Access

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11 Citaten (Scopus)

102 Downloads (Pure)

2020

Vps13 is required for timely removal of nurse cell corpses

Faber, A. I. E., van der Zwaag, M., Schepers, H., Eggens-Meijer, E., Kanon, B., IJsebaart, C., Kuipers, J., Giepmans, B. N. G., Freire, R., Grzeschik, N. A., Rabouille, C. & Sibon, O. C. M., 29-okt.-2020, In: DEVELOPMENT. 147, 20, 15 blz., 191759.

Onderzoeksoutput: Article › Academic › peer review

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9 Citaten (Scopus)

160 Downloads (Pure)

2019

CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases

Lambrechts, R. A., Schepers, H., Yu, Y., van der Zwaag, M., Autio, K. J., Vieira-Lara, M. A., Bakker, B. M., Tijssen, M. A., Hayflick, S. J., Grzeschik, N. A. & Sibon, O. C., 7-nov.-2019, In: EMBO Molecular Medicine. 21 blz., 10488.

Onderzoeksoutput: Article › Academic › peer review

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47 Citaten (Scopus)

286 Downloads (Pure)

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

Yeshaw, W. M., van der Zwaag, M., Pinto, F., Lahaye, L. L., Faber, A. I., Gómez-Sánchez, R., Dolga, A. M., Poland, C., Monaco, A. P., van IJzendoorn, S., Grzeschik, N. A., Velayos-Baeza, A. & Sibon, O. C., 11-feb.-2019, In: eLife. 8, 37 blz., 43561.

Onderzoeksoutput: Article › Academic › peer review

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114 Citaten (Scopus)

1828 Downloads (Pure)

North Sea Progressive Myoclonus Epilepsy is Exacerbated by Heat, A Phenotype Primarily Associated with Affected Glia

Lambrechts, R. A., Polet, S. S., Hernandez-Pichardo, A., van Ninhuys, L., Gorter, J. A., Grzeschik, N. A., de Koning-Tijssen, M. A. J., de Koning, T. J. & Sibon, O. C. M., 15-dec.-2019, In: Neuroscience. 423, blz. 1-11 11 blz.

Onderzoeksoutput: Article › Academic › peer review

Open Access

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10 Citaten (Scopus)

318 Downloads (Pure)

2018

Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy

Iuso, A., Wiersma, M., Schüller, H.-J., Pode-Shakked, B., Marek-Yagel, D., Grigat, M., Schwarzmayr, T., Berutti, R., Alhaddad, B., Kanon, B., Grzeschik, N. A., Okun, J. G., Perles, Z., Salem, Y., Barel, O., Vardi, A., Rubinshtein, M., Tirosh, T., Dubnov-Raz, G. & Messias, A. C. & 18 anderen, Terrile, C., Barshack, I., Volkov, A., Avivi, C., Eyal, E., Mastantuono, E., Kumbar, M., Abudi, S., Braunisch, M., Strom, T. M., Meitinger, T., Hoffmann, G. F., Prokisch, H., Haack, T. B., Brundel, B. J. J. M., Haas, D., Sibon, O. C. M. & Anikster, Y., 7-jun.-2018, In: American Journal of Human Genetics. 102, 6, blz. 1018-1030 13 blz.

Onderzoeksoutput: Article › Academic › peer review

49 Citaten (Scopus)

2017

Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency

Di Meo, I., Colombelli, C., Srinivasan, B., de Villiers, M., Hamada, J., Jeong, S. Y., Fox, R., Woltjer, R. L., Tepper, P. G., Lahaye, L. L., Rizzetto, E., Harrs, C. H., de Boer, T., van der Zwaag, M., Jenko, B., Čusak, A., Pahor, J., Kosec, G., Grzeschik, N. A. & Hayflick, S. J. & 2 anderen, Tiranti, V. & Sibon, O. C. M., 12-sep.-2017, In: Scientific Reports. 7, 1, 12 blz., 11260.

Onderzoeksoutput: Article › Academic › peer review

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28 Citaten (Scopus)

459 Downloads (Pure)

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

Parsons, L. M., Grzeschik, N. A., Amaratunga, K., Burke, P., Quinn, L. M. & Richardson, H. E., 1-aug.-2017, In: G3 : Genes, Genomes, Genetics. 7, 8, blz. 2497-2509 13 blz.

Onderzoeksoutput › Academic › peer review

Open Access

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10 Citaten (Scopus)

253 Downloads (Pure)

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

Vonk, J. J., Yeshaw, W. M., Pinto, F., Faber, A. I. E., Lahaye, L. L., Kanon, B., van der Zwaag, M., Velayos-Baeza, A., Freire, R., van IJzendoorn, S. C., Grzeschik, N. A. & Sibon, O. C. M., 20-jan.-2017, In: PLoS ONE. 12, 1, 21 blz., e0170106.

Onderzoeksoutput: Article › Academic › peer review

Open Access

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30 Citaten (Scopus)

398 Downloads (Pure)

Note of concern: Guanine quadruplex structures localize to heterochromatin

Hoffmann, R. F., Moshkin, Y. M., Mouton, S., Grzeschik, N. A., Kalicharan, R. D., Kuipers, J., Wolters, A. H. G., Nishida, K., Romashchenko, A. V., Postberg, J., Lipps, H., Berezikov, E., Sibon, O. C. M., Giepmans, B. N. G. & Lansdorp, P. M., 2-jun.-2017, In: Nucleic Acids Research. 45, 10, blz. 6253-6253 1 blz.

Onderzoeksoutput: Editorial › Academic › peer review

Open Access

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3 Citaten (Scopus)

258 Downloads (Pure)

2016

Guanine quadruplex structures localize to heterochromatin

Hoffmann, R. F., Moshkin, Y. M., Mouton, S., Grzeschik, N. A., Kalicharan, R. D., Kuipers, J., Wolters, A. H. G., Nishida, K., Romashchenko, A. V., Postberg, J., Lipps, H., Berezikov, E., Sibon, O. C. M., Giepmans, B. N. G. & Lansdorp, P. M., 8-jan.-2016, In: Nucleic Acids Research. 44, 1, blz. 152-163 12 blz.

Onderzoeksoutput: Article › Academic › peer review

Open Access

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55 Citaten (Scopus)

348 Downloads (Pure)

2015

Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis

Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A., Podgorsek, A., Kosec, G., Petkovic, H., Hayflick, S., Tiranti, V., Reijngoud, D.-J., Grzeschik, N. A. & Sibon, O. C. M., okt.-2015, In: Nature Chemical Biology. 11, 10, blz. 784-792.e3 12 blz.

Onderzoeksoutput: Article › Academic › peer review

98 Citaten (Scopus)

Overexpression of Cystathionine gamma-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3

Snijder, P. M., Baratashvili, M., Grzeschik, N. A., Leuvenink, H. G. D., Kuijpers, L., Huitema, S., Schaap, O., Giepmans, B. N. G., Kuipers, J., Miljkovic, J. L., Mitrovic, A., Bos, E. M., Szabo, C., Kampinga, H. H., Dijkers, P. F., den Dunnen, W. F. A., Filipovic, M. R., van Goor, H. & Sibon, O. C. M., 2015, In: Molecular medicine. 21, blz. 758-768 11 blz.

Onderzoeksoutput: Article › Academic › peer review

Open Access

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37 Citaten (Scopus)

334 Downloads (Pure)

Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor

Portela, M., Parsons, L. M., Grzeschik, N. A. & Richardson, H. E., 19-mei-2015, In: Cell Cycle. 14, 10, blz. 1496-1506 11 blz.

Onderzoeksoutput › Academic › peer review

17 Citaten (Scopus)

2014

Lgl Regulates Notch Signaling via Endocytosis, Independently of the Apical aPKC-Par6-Baz Polarity Complex

Parsons, L. M., Portela, M., Grzeschik, N. A. & Richardson, H. E., 22-sep.-2014, In: Current Biology. 24, 18, blz. 2073-2084 12 blz.

Onderzoeksoutput › Academic › peer review

33 Citaten (Scopus)

Lgl regulates the hippo pathway independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK

Parsons, L. M., Grzeschik, N. A. & Richardson, H. E., 1-jun.-2014, In: Cancers. 6, 2, blz. 879-896 18 blz.

Onderzoeksoutput: Article › Academic › peer review

Open Access

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13 Citaten (Scopus)

294 Downloads (Pure)

2012

Cofilin/Twinstar Phosphorylation Levels Increase in Response to Impaired Coenzyme A Metabolism

Siudeja, K., Grzeschik, N. A., Rana, A., de Jong, J. & Sibon, O. C. M., 17-aug.-2012, In: PLoS ONE. 7, 8, 9 blz., e43145.

Onderzoeksoutput: Article › Academic › peer review

Open Access

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14 Citaten (Scopus)

260 Downloads (Pure)

2010

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F. & Richardson, H. E., 13-apr.-2010, In: Current Biology. 20, 7, blz. 573-581 9 blz.

Onderzoeksoutput › Academic › peer review

295 Citaten (Scopus)

Lgl, the SWH pathway and tumorigenesis It's a matter of context & competition!

Grzeschik, N. A., Parsons, L. M. & Richardson, H. E., 15-aug.-2010, In: Cell Cycle. 9, 16, blz. 3202-3212 11 blz.

Onderzoeksoutput › Academic › peer review

35 Citaten (Scopus)

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

Parsons, L. M., Grzeschik, N. A., Allott, M. L. & Richardson, H. E., 2010, In: Fly. 4, 4, blz. 288-293 6 blz.

Onderzoeksoutput › Academic › peer review

34 Citaten (Scopus)

2009

Lgl acts antagonistically to Crumbs and aPKC to regulate the Salvador/Warts/Hippo pathway

Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F. & Richardson, H. E., aug.-2009, In: Mechanisms of development. 126, blz. S61-S61 1 blz.

Onderzoeksoutput › Academic

Modelling cancer in Drosophila: The junctional neoplastic tumour suppressors, Lgl, Dlg and Scrib, in cell proliferation control and tumourigenesis

Richardson, H., Grzeschik, N., Parsons, L., Allott, M., Turkel, N., Goulding, K., Boulden, J., Harvey, K., Martin-Blanco, E. & Brumby, A., aug.-2009, In: Mechanisms of development. 126, blz. S26-S26 1 blz.

Onderzoeksoutput › Academic

Nicola Grzeschik

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