Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
Persoonlijk profiel
Speerpunten
Ik onderzoek hoe iemands genetische aanleg (DNA) en niet-coderende RNA moleculen (micro-RNAs (miRNAs) en long non-coding RNAs (lncRNAs)) bijdragen aan de kans op het krijgen van complex genetische, immuun-gemedieerde ziekten zoals Coeliakie, Inflammatoire Darm Ziekte (IBD), Non-alcoholische Steatohepatitis (NASH) en Multipele Sclerose (MS).
Ik gebruik voornamelijk patientenmateriaal en cellijnmodellen als modelsystemen voor ziektes die ik manipuleer en uitlees met de nieuwste 'genomics technologien' zoals bijvoorbeeld CRISPR/Cas9, SNP (single nucleotide polymorphism) arrays, single-cell RNA sequencing, single-cell ATACseq, en oLINK targeted proteomics.
Recentelijk focus ik op de ontwikkeling van organen-op-chip platforms. Hiertoe gebruik ik patientencellen die ik genetisch reprogrammeer tot zogenaamde induced pluriptent stem cells (iPSCs) en die ik op hun beurt differentieer tot darmwandcellen, immuuncellen, bloedvatcellen, of levercellen. De microfluidische darm-op-chip of lever-op-chip systemen die ik vervaardig zijn de meest veelbelovende modelsystemen voor 'personlized medicine' applicaties en onderzoeksvraagstellingen omdat de uitgangscellen zijn verkregen van patienten, wat betekend dat de erfelijke aanleg die aan de basis van de ziekte ligt aanwezig is.
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels
Uniken Venema, W. T. C., Ramírez-Sánchez, A. D., Bigaeva, E., Withoff, S., Jonkers, I., McIntyre, R. E., Ghouraba, M., Raine, T., Weersma, R. K., Franke, L., Festen, E. A. M. & van der Wijst, M. G. P., 14-jun-2022, In: Scientific Reports. 12, 14 blz., 9897.Onderzoeksoutput › Academic › peer review
Open AccessBestand -
Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers
Ramírez-Sánchez, A. D., Chu, X., Modderman, R., Kooy-Winkelaar, Y., Koletzko, S., Korponay-Szabó, I. R., Troncone, R., Wijmenga, C., Mearin, L., Withoff, S., Jonkers, I. H. & Li, Y., 15-mrt-2022, In: Frontiers in Immunology. 13, 14 blz., 843086.Onderzoeksoutput › Academic › peer review
Open AccessBestand23 Downloads (Pure) -
A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease
Tan, I. L., Barisani, D., Panceri, R., Modderman, R., Visschedijk, M., Weersma, R. K., Wijmenga, C., Jonkers, I., Coutinho de Almeida, R. & Withoff, S., 21-okt-2021, In: International Journal of Molecular Sciences. 22, 21, 16 blz., 11382.Onderzoeksoutput › Academic › peer review
Open AccessBestand2 Citaten (Scopus)19 Downloads (Pure) -
Circulating miRNAs as Potential Biomarkers for Celiac Disease Development
Tan, I. L., Coutinho de Almeida, R., Modderman, R., Stachurska, A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M., Martinez-Ojinaga, E., Shamir, R., Auricchio, R., Korponay-Szabó, I. R., Castillejo, G., Szajewska, H., Koletzko, S., Zhernakova, A., Kumar, V., Li, Y., Visschedijk, M. C., Weersma, R. K. & 5 anderen, , 7-dec-2021, In: Frontiers in Immunology. 12, 16 blz., 734763.Onderzoeksoutput › Academic › peer review
Open AccessBestand1 Citaat (Scopus)39 Downloads (Pure) -
Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability
Matzaraki, V., Le, K. T. T., Jaeger, M., Aguirre-Gamboa, R., Johnson, M. D., Sanna, S., Rosati, D., Franke, L., Zhernakova, A., Fu, J., Withoff, S., Jonkers, I., Li, Y., Joosten, L. A. B., Netea, M. G., Wijmenga, C. & Kumar, V., 26-aug-2021, In: Frontiers in Immunology. 12, 13 blz., 662171.Onderzoeksoutput › Academic › peer review
Open AccessBestand2 Citaten (Scopus)47 Downloads (Pure)
Datasets
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Additional file 17 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
Chu, X. (Contributor), Aguirre Gamboa, R. (Contributor), Koenen, H. J. P. M. (Contributor), de Bree, C. (Contributor), Franke, L. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Bakker, O. (Contributor), Xu, C. (Contributor), Jonkers, I. (Contributor), Jansen, T. (Contributor), Withoff, S. (Contributor), Najhawan, M. (Contributor), Oosting, M. (Contributor), Jain, M. (Contributor), Mourits, V. P. (Contributor), Dao, K. (Contributor), Smeekens, S. P. (Contributor), Li, Y. (Contributor), Watrous, J. D. (Contributor), Clevers, H. (Contributor), Jaeger, M. (Contributor), Mathews, I. T. (Contributor), Joosten, I. (Contributor), Koeken, V. A. C. M. (Contributor), Xavier, R. J. (Contributor), Sharma, S. (Contributor), Netea, M. G. (Contributor), Beumer, J. (Contributor), Wijmenga, C. (Contributor), Joosten, L. A. B. (Contributor), Moorlag, S. (Contributor), Netea-Maier, R. T. (Contributor) & Sanna, S. (Contributor), figshare Academic Research System, 7-jul-2021
DOI: 10.6084/m9.figshare.14921200.v1
Dataset
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Additional file 23 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
Chu, X. (Contributor), Sanna, S. (Contributor), Koenen, H. J. P. M. (Contributor), Dao, K. (Contributor), Mathews, I. T. (Contributor), Withoff, S. (Contributor), Najhawan, M. (Contributor), Jonkers, I. (Contributor), Moorlag, S. (Contributor), Netea-Maier, R. T. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Mourits, V. P. (Contributor), Netea, M. G. (Contributor), Wijmenga, C. (Contributor), Xu, C. (Contributor), Oosting, M. (Contributor), Watrous, J. D. (Contributor), Sharma, S. (Contributor), Franke, L. (Contributor), Smeekens, S. P. (Contributor), Beumer, J. (Contributor), Jansen, T. (Contributor), Xavier, R. J. (Contributor), Koeken, V. A. C. M. (Contributor), de Bree, C. (Contributor), Li, Y. (Contributor), Bakker, O. (Contributor), Joosten, L. A. B. (Contributor), Joosten, I. (Contributor), Clevers, H. (Contributor), Aguirre Gamboa, R. (Contributor), Jaeger, M. (Contributor) & Jain, M. (Contributor), figshare Academic Research System, 7-jul-2021
DOI: 10.6084/m9.figshare.14921221.v1
Dataset
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Additional file 3 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
Chu, X. (Contributor), Li, Y. (Contributor), Xavier, R. J. (Contributor), Aguirre Gamboa, R. (Contributor), Joosten, I. (Contributor), Sanna, S. (Contributor), Netea, M. G. (Contributor), Netea-Maier, R. T. (Contributor), Joosten, L. A. B. (Contributor), Xu, C. (Contributor), Oosting, M. (Contributor), Beumer, J. (Contributor), Jansen, T. (Contributor), Jain, M. (Contributor), Clevers, H. (Contributor), Mathews, I. T. (Contributor), Withoff, S. (Contributor), Smeekens, S. P. (Contributor), Franke, L. (Contributor), Watrous, J. D. (Contributor), Bakker, O. (Contributor), Koeken, V. A. C. M. (Contributor), Mourits, V. P. (Contributor), de Bree, C. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Jonkers, I. (Contributor), Dao, K. (Contributor), Sharma, S. (Contributor), Wijmenga, C. (Contributor), Moorlag, S. (Contributor), Koenen, H. J. P. M. (Contributor), Najhawan, M. (Contributor) & Jaeger, M. (Contributor), figshare Academic Research System, 7-jul-2021
DOI: 10.6084/m9.figshare.14921233.v1
Dataset
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Additional file 11 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
Chu, X. (Contributor), Moorlag, S. (Contributor), Clevers, H. (Contributor), Koenen, H. J. P. M. (Contributor), Bakker, O. (Contributor), Watrous, J. D. (Contributor), Li, Y. (Contributor), Smeekens, S. P. (Contributor), Jain, M. (Contributor), Sharma, S. (Contributor), Dao, K. (Contributor), Joosten, I. (Contributor), de Bree, C. (Contributor), Sanna, S. (Contributor), Franke, L. (Contributor), Xu, C. (Contributor), Jonkers, I. (Contributor), Beumer, J. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Xavier, R. J. (Contributor), Najhawan, M. (Contributor), Koeken, V. A. C. M. (Contributor), Wijmenga, C. (Contributor), Mathews, I. T. (Contributor), Netea-Maier, R. T. (Contributor), Netea, M. G. (Contributor), Mourits, V. P. (Contributor), Withoff, S. (Contributor), Joosten, L. A. B. (Contributor), Aguirre Gamboa, R. (Contributor), Jansen, T. (Contributor), Oosting, M. (Contributor) & Jaeger, M. (Contributor), figshare Academic Research System, 7-jul-2021
DOI: 10.6084/m9.figshare.14920794.v1
Dataset
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Additional file 18 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
Chu, X. (Contributor), de Bree, C. (Contributor), Dao, K. (Contributor), Sanna, S. (Contributor), Moorlag, S. (Contributor), Jansen, T. (Contributor), Wijmenga, C. (Contributor), Jain, M. (Contributor), Bakker, O. (Contributor), Xavier, R. J. (Contributor), Li, Y. (Contributor), Aguirre Gamboa, R. (Contributor), Koenen, H. J. P. M. (Contributor), Netea-Maier, R. T. (Contributor), Joosten, L. A. B. (Contributor), Sharma, S. (Contributor), Beumer, J. (Contributor), Clevers, H. (Contributor), Joosten, I. (Contributor), Smeekens, S. P. (Contributor), Withoff, S. (Contributor), Jaeger, M. (Contributor), Koeken, V. A. C. M. (Contributor), Mathews, I. T. (Contributor), Franke, L. (Contributor), Mourits, V. P. (Contributor), Netea, M. G. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Oosting, M. (Contributor), Najhawan, M. (Contributor), Jonkers, I. (Contributor), Xu, C. (Contributor) & Watrous, J. D. (Contributor), figshare Academic Research System, 7-jul-2021
DOI: 10.6084/m9.figshare.14921203.v1
Dataset
Knipsels
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Glutenintolerantie onderzoeken met minidarmpjes
19/09/2019
1 Mediabijdrage
Pers / media: Activiteiten met een maatschappelijk belang › Popular
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Darmen op een chip
17/03/2019
1 Mediabijdrage
Pers / media: Activiteiten met een maatschappelijk belang › Popular
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Grootse plannen met piepkleine organen.
30/05/2018
1 Mediabijdrage
Pers / media: Activiteiten met een maatschappelijk belang › Popular
Prijzen
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Fellowship of the Catherina Research Foundation
Withoff, Sebo (Recipient), 2005
Prijs: Fellowship awarded competitively › Professional
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