Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
Persoonlijk profiel
Speerpunten
Curriculum Vitae
Sophia Bruggeman (The Netherlands, 1979) studied Biology at the University of Nijmegen. As PhD student, she worked at the Netherlands Cancer Institute on the role of Polycomb group genes in brain development and cancer (2008, cum laude). She next moved to King's College London to work on the development of the chick and zebrafish forebrain on a KWF postdoctoral fellowship. This fellowship was completed at the European Research Institute for the Biology of Ageing (ERIBA/University Medical Center Groningen).
After awardance of a Rosalind Franklin fellowship (tenure track position) and a KWF Cancer Research career award, Sophia started her own research group at the department of Pediatric Oncology and Hematology/Pediatrics, UMCG (2014). In 2019, Sophia's research group moved to ERIBA, UMCG. Her research aims at understaning how normal neurodevelopmental processes influence pediatric brain cancer initiation and progression.
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum
Bockaj, I., Martini, T. E., Smit, M. J., Armandari, I., Bakker, B., Wardenaar, R., Meeuwsen-de Boer, T. G. J., Bakker, P. L., Spierings, D. C. J., Hoving, E. W., Guryev, V., Foijer, F. & Bruggeman, S. W. M., 30-aug.-2022, In: International Journal of Molecular Sciences. 23, 17, 15 blz., 9852.Onderzoeksoutput › Academic › peer review
Open AccessBestand1 Citaat (Scopus)20 Downloads (Pure) -
The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magalhães, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., jun.-2022, In: Journal of Cell Science. 135, 11, 14 blz., jeb258608.Onderzoeksoutput › Academic › peer review
Open AccessBestand2 Citaten (Scopus)32 Downloads (Pure) -
CREB signaling activity correlates with differentiation and survival in medulloblastoma
Armandari, I., Zomerman, W. W., Plasschaert, S. L. A., Smit, M. J., Martini, T. E., Magalhaes, E. S. D. C., Hogeling, S. M., Rozema-Huizinga, G. C., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., de Bont, E. S. J. M. & Bruggeman, S. W. M., 9-aug.-2021, In: Scientific Reports. 11, 1, 12 blz., 16077.Onderzoeksoutput › Academic › peer review
Open AccessBestand31 Downloads (Pure) -
Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study
Hoff, F. W., van Dijk, A. D., Qiu, Y. H., Ruvolo, P. P., Gerbing, R. B., Leonti, A. R., Jenkins, G. N., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T., Meshinchi, S., De Bont, E., Bruggeman, S. W., Kornblau, S. M. & Horton, T. M., 25-feb.-2021, In: Blood. 137, 8, blz. 1050-1060 11 blz.Onderzoeksoutput › Academic › peer review
Open AccessBestand9 Citaten (Scopus)56 Downloads (Pure) -
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma
Bočkaj, I., Martini, T. E. I., de Camargo Magalhães, E. S., Bakker, P. L., Meeuwsen-de Boer, T. G. J., Armandari, I., Meuleman, S. L., Mondria, M. T., Stok, C., Kok, Y. P., Bakker, B., Wardenaar, R., Seiler, J., Broekhuis, M. J. C., van den Bos, H., Spierings, D. C. J., Ringnalda, F. C. A., Clevers, H., Schüller, U., van Vugt, M. A. T. M., & 2 anderen, nov.-2021, In: PLoS genetics. 17, 11, 28 blz., 1009868.Onderzoeksoutput › Academic › peer review
Open AccessBestand7 Citaten (Scopus)34 Downloads (Pure)
Activiteiten
- 1 Visiting an external institution
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Princess Maxima Ctr Paediat Oncol
Sophia Bruggeman (Visiting researcher)
19-dec.-2017Activiteit: Visiting an external institution › Academic
Datasets
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Smit_Martini_et_al_manuscript_J_Cell_Science_2022_raw_data
Bruggeman, S. (Contributor), Mendeley Data, 19-mei-2022
DOI: 10.17632/kvx2wxfnyj.1, https://data.mendeley.com/datasets/kvx2wxfnyj
Dataset
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"CREB signaling activity correlates with differentiation and survival in medulloblastoma" by Armandari et al.
Bruggeman, S. (Contributor), University of Groningen, 21-jul.-2021
DOI: 10.17632/s7j3gkd58p.1, https://data.mendeley.com/datasets/s7j3gkd58p
Dataset
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"The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma" by Bockaj, Martini, de Camargo Magalhães et al, PLoS Genetics 2021
Bruggeman, S. (Contributor), Mendeley Data, 3-nov.-2021
DOI: 10.17632/3dwkjjc85m.1, https://data.mendeley.com/datasets/3dwkjjc85m
Dataset
Prijzen
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Differential drug sensitivity in pediatric brain cancer precursor cells: towards tailored treatments for infant and childhood medulloblastoma.
Bruggeman, Sophia (Recipient), 19-jul.-2018
Prijs: Fellowship awarded competitively › Academic