Wim Timens

Zoekresultaten

• 2017

  Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers

  Obeidat, M., Nie, Y., Fishbane, N., Li, X., Bossé, Y., Joubert, P., Nickle, D. C., Hao, K., Postma, D. S., Timens, W., Sze, M. A., Shannon, C. P., Hollander, Z., Ng, R. T., McManus, B., Miller, B. E., Rennard, S., Spira, A., Hackett, T. L. & Lam, W. & 6 anderen, Lam, S., Faner, R., Agusti, A., Hogg, J. C., Sin, D. D. & Paré, P. D., okt.-2017, In: American Journal of Respiratory Cell and Molecular Biology. 57, 4, blz. 411-418 8 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

  • Genetics 100%
  • Messenger RNA 100%
  • B Cell 50%
  • Gene Expression Profiling 50%
  • ASRGL1 16%
  29 Citaten (Scopus)

• Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

  Mckay, J. D., Hung, R. J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D. C., Caporaso, N. E., Johansson, M., Xiao, X., Li, Y., Byun, J., Dunning, A., Pooley, K. A., Qian, D. C., Ji, X., Liu, G., Timofeeva, M. N., Bojesen, S. E., Wu, X. & Le Marchand, L. & 31 anderen, Albanes, D., Bickeboeller, H., Aldrich, M. C., Bush, W. S., Tardon, A., Rennert, G., Teare, M. D., Field, J. K., Kiemeney, L. A., Lazarus, P., Haugen, A., Lam, S., Schabath, M. B., Andrew, A. S., Shen, H., Hong, Y.-C., Yuan, J.-M., Bertazzi, P. A., Pesatori, A. C., Ye, Y., Diao, N., Su, L., Zhang, R., Brhane, Y., Leighl, N., Johansen, J. S., Mellemgaard, A., Saliba, W., Marcus, M. W., Timens, W. & SpiroMeta Consortium, jul.-2017, In: Nature Genetics. 49, 7, blz. 1126-+ 9 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  • Genetic Susceptibility 100%
  • Gene Expression 50%
  • Candidate Gene 50%
  • Telomere 50%
  • Expression Quantitative Trait Loci 50%
  489 Citaten (Scopus)

• Late Breaking Abstract - Functional investigation of the corticosteroid resistance candidate FKBP5 using a CRISPR-Cas9 knockout model

  Faiz, A., Wisman, M., Hiemstra, P. S., Timens, W., Woodruff, P., Christenson, S., Van Den Berge, M., Heijink, I. H. & Koppelman, G. H., 1-sep.-2017, In: European Respiratory Journal. 50, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair?

  Brandsma, C.-A., de Vries, M., Costa, R., Woldhuis, R. R., Königshoff, M. & Timens, W., 31-dec.-2017, In: European Respiratory Review. 26, 146, 10 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand

  • Aging 100%
  • Chronic Obstructive Pulmonary Disease 100%
  • Tissue Repair 100%
  • Abnormal Tissue 100%
  • Lung Aging 100%
  154 Citaten (Scopus)

  99 Downloads (Pure)

• Mesenchymale stromale stamceltherapie voor emfyseem: Een kijkje in de toekomst

  Heijink, H., Kruk, D., Slebos, D., Verschuuren, E. A. M., Timens, W. & ten Hacken, N. H. T., mrt.-2017, In: Nederlands tijdschrift voor allergie & astma. 17, 1, blz. 12-19 8 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Maar 100%
  • Eigen 33%
  • Bleek 33%
  • Safety Study 33%
  59 Downloads (Pure)

• microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach

  Conickx, G., Avila Cobos, F., van den Berge, M., Faiz, A., Timens, W., Hiemstra, P. S., Joos, G. F., Brusselle, G. G., Mestdagh, P. & Bracke, K. R., 9-okt.-2017, In: Scientific Reports. 7, 1, 14 blz., 12871.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Mouse 100%
  • Supernatant 100%
  • Immune Response 33%
  • Inflammation Response 33%
  • ELISA 33%
  50 Citaten (Scopus)

  307 Downloads (Pure)

• miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD

  Osei, E. T., Florez-Sampedro, L., Tasena, H., Faiz, A., Noordhoek, J. A., Timens, W., Postma, D. S., Hackett, T. L., Heijink, I. H. & Brandsma, C.-A., 2017, In: European Respiratory Journal. 49, 5

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Fibroblast 100%
  • Interleukin 1 100%
  • MiR-146a-5p 100%
  • Interleukin-1 80%
  • Lung Fibroblast 62%
  56 Citaten (Scopus)

  58 Downloads (Pure)

• Molecular Tumor Board treatment predictions on rare EGFR exon 20 mutations

  van der Wekken, A. J., Groves, M. R., ter Elst, A., 't Hart, N. A., Hijmering-Kappelle, L. B., Hiltermann, T. J., van den Berg, A., Timens, W., Schuuring, E. & Groen, H. J., jul.-2017, In: Cancer Research. 77, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Mutation patterns in small cell and non-small cell lung cancer patients suggest a different level of heterogeneity between primary and metastatic tumors

  Saber, A., Hiltermann, T. J. N., Kok, K., Terpstra, M. M., de Lange, K., Timens, W., Groen, H. J. M. & van den Berg, A., 4-jan.-2017, In: CARCINOGENESIS. 38, 2, blz. 144-151 8 blz.

  Onderzoeksoutput › Academic › peer review

  • Exome Sequencing 100%
  • Phylogenetic Tree 33%
  • Single Primer Enrichment Technology 25%
  32 Citaten (Scopus)

• Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

  Boudewijn, I. M., Faiz, A., Steiling, K., van der Wiel, E., Telenga, E. D., Hoonhorst, S. J. M., ten Hacken, N. H. T., Brandsma, C.-A., Kerstjens, H. A. M., Timens, W., Heijink, I. H., Jonker, M. R., de Bruin, H. G., Vroegop, J. S., Pasma, H. R., Boersma, W. G., Wielders, P., van den Elshout, F., Mansour, K. & Spira, A. & 4 anderen, Lenburg, M. E., Guryev, V., Postma, D. S. & van den Berge, M., 21-dec.-2017, In: Respiratory Research. 18, 10 blz., 213.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand

  • Nasal 100%
  • Gene Expression 100%
  • COPD Patients 62%
  • Gene Expression Profiling 57%
  • Gene Expression Profile 37%
  33 Citaten (Scopus)

  441 Downloads (Pure)

• Onderzoek naar biomarkers in plasma voor het (snel) vaststellen van een tumorrespons bij de behandeling met nivolumab bij KRAS-gemuteerd niet-kleincellig longkanker: Een exploratief onderzoek

  Kappelle, L., Groen, H. J. M., de Bock, G. H., Weersma, R., Timens, W., 't Hart, N., Schuuring, E. & Hiltermann, T., nov.-2017, In: Nederlands Tijdschrift voor Oncologie. 14, blz. 280-284 5 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand
  40 Downloads (Pure)

• Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression

  van der Wekken, A. J., Kuiper, J. L., Saber, A., Terpstra, M. M., Wei, J., Hiltermann, T. J. N., Thunnissen, E., Heideman, D. A. M., Timens, W., Schuuring, E., Kok, K., Smit, E. F., van den Berg, A. & Groen, H. J. M., 1-aug.-2017, In: PLoS ONE. 12, 8, 15 blz., e0182885.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Disease Exacerbation 100%
  • Non Small Cell Lung Cancer 100%
  • Overall Survival 100%
  • Protein Tyrosine Kinase Inhibitor 100%
  • Epidermal Growth Factor Receptor 100%
  19 Citaten (Scopus)

  446 Downloads (Pure)

• Peripheral Th2-Related Biomarkers In Chronic Obstructive Pulmonary Disease (COPD) Patients In The Glucold (groningen Leiden Universities Corticosteroids In Obstructive Lung Disease) Study

  Tew, W., Kulkarni, P., Holweg, C. H., Brandsma, C. A., Timens, W., Grimbaldeston, M., Hiemstra, P. S., van den Berge, M. & Neighbors, M., 2017, In: American Journal of Respiratory and Critical Care Medicine. 195, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Potential Role For An Imbalance Between Airway Smooth Muscle Laminin alpha 4 And alpha 5 Expression In Asthma

  Prabhala, P., Wright, D., Bitter, C., Robbe, P., Ten Hacken, N. H. T., van den Berge, M., Timens, W., Meurs, H. & Dekkers, B. G. J., 2017, In: American Journal of Respiratory and Critical Care Medicine. 195, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Pregnancy smoking: Tissue- and sex-specific drift of Igf1r and Igf1 methylation in mouse fetuses and neonates

  Meyer, K. F. M., Krauss-Etschmann, S., Verkaik-Schakel, R. N., Timens, W., Kobzik, L., Plosch, T. & Hylkema, M., 1-sep.-2017, In: European Respiratory Journal. 50, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring

  Meyer, K. F., Krauss-Etschmann, S., Kooistra, W., Reinders-Luinge, M., Timens, W., Kobzik, L., Plösch, T. & Hylkema, M. N., 5-apr.-2017, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 4, blz. L542-L555 14 blz.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand

  • Mouse 100%
  • Progeny 100%
  • Methylation 100%
  • Messenger RNA 100%
  • Prenatal Exposure 100%
  28 Citaten (Scopus)

  346 Downloads (Pure)

• Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation

  Obeidat, M., Li, X., Burgess, S., Zhou, G., Fishbane, N., Hansel, N. N., Bossé, Y., Joubert, P., Hao, K., Nickle, D. C., van den Berge, M., Timens, W., Cho, M. H., Hobbs, B. D., de Jong, K., Boezen, M., Hung, R. J., Rafaels, N., Mathias, R. & Ruczinski, I. & 5 anderen, Beaty, T. H., Barnes, K. C., Paré, P. D., Sin, D. D. & International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study, nov.-2017, In: European Respiratory Journal. 50, 5, 11 blz., 1700657.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Mendelian Randomization 100%
  • Surfactant Protein D 100%
  • Gene Expression 20%
  • Genetic Divergence 10%
  • Genetic Variation 10%
  38 Citaten (Scopus)

  59 Downloads (Pure)

• Target gene identification of TGF-beta-induced miR-455-3p and miR-21-3p in lung fibroblasts

  Ong, J., Timens, W., Rajendran, V., Algra, A., Spira, A., Lenburg, M., Campbell, J., van den Berge, M., Postma, D., van den Berg, A., Kluiver, J. & Brandsma, C.-A., 1-sep.-2017, In: European Respiratory Journal. 50, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific

  Meyer, K. F., Verkaik-Schakel, R. N., Timens, W., Kobzik, L., Plösch, T. & Hylkema, M. N., 2017, In: Epigenetics. 12, blz. 1076-1091 16 blz.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Methylation 100%
  • Prenatal Smoking 100%
  • Gene Expression 40%
  • Progeny 40%
  • CpG Site 40%
  19 Citaten (Scopus)

  264 Downloads (Pure)

• The Role Of Interleukin-1 In Driving Inflammation And Remodeling In The Asthmatic Emtu

  Osei, E. T., Mostaco-Guidolin, L., Warner, S., Hallstrand, T. S., Timens, W., Postma, D. S., Brandsma, C. A., Heijink, I. H. & Hackett, T.-L., 2017, In: American Journal of Respiratory and Critical Care Medicine. 195, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Treatment decision-making of rare ERBB2 (HER2) mutations in lung cancer; a role for multidisciplinary molecular tumor boards: A role for multidisciplinary molecular tumor boards

  ter Elst, A., 't Hart, N. A., van der Wekken, A. J., Timens, W., Hijmering-Kappelle, L. B., Hospers, G. A., Jalving, H., van der Logt, E. M., van Kempen, L. C., Oosting, S. F., Groves, M. R., Hiltermann, T. J., van den Berg, A., Groen, H. J. & Schuuring, E., jul.-2017, In: Cancer Research. 77, 2 blz., Abstract 754.

  Onderzoeksoutput: Meeting Abstract › Academic

• Unraveling effects of lung function GWAS candidates using airway epithelial eQTLs

  Faiz, A., Berg, M., Vermeulen, C. J., ten Hacken, N., Timens, W., Brandsma, C.-A., Koppelman, G. H., Heijink, I. H. & van den Berge, M., 1-sep.-2017, In: European Respiratory Journal. 50, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Widening of Alveolar Septa in Transbronchial Biopsies with Antibody Mediated Rejection (AMR): Preliminary Data from Multicenter Pilot Study

  Calabrese, F., Hirschi, S., Chenard, M., Montero-Fernandez, M., Neil, D., Timens, W., Verbeken, E., Perissinotto, E., Lunardi, E., Cozzi, E., Levine, J. D. & Goddard, M. E., apr.-2017, In: The Journal of Heart and Lung Transplantation. 36, 4, blz. S135-S135 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic
• 2016

  Accelerated Lung Aging In COPD: A Lung Tissue Gene Expression Signature

  Vries, de, M., Faiz, A., Postma, D. S., Sin, D. D., Bosse, Y., Nickle, D. C., Timens, W., Van den Berge, M. & Brandsma, C.-A., 2016, In: American Journal of Respiratory and Critical Care Medicine. 193, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Advanced glycation endproducts and their receptor in different body compartments in COPD

  Hoonhorst, S. J. M., Loi, A. T. L. T., Pouwels, S. D., Faiz, A., Telenga, E. D., van den Berge, M., Koenderman, L., Lammers, J.-W. J., Boezen, H. M., van Oosterhout, A., Lodewijk, M. E., Timens, W., Postma, D. S. & ten Hacken, N. H. T., 26-apr.-2016, In: Respiratory Research. 17, 12 blz., 46.

  Onderzoeksoutput: Article › Academic › peer review

  Open Access

  Bestand

  • Eicosanoid Receptor 100%
  • Glycation 100%
  • Advanced Glycation End-Product 100%
  • Blood Plasma 57%
  • Sputum 42%
  51 Citaten (Scopus)

  368 Downloads (Pure)

• A potential role for extracellular matrix proteins in lung ageing in COPD

  de Vries, M., Faiz, A., Postma, D. S., Sin, D. D., Bosse, Y., Nickle, D. C., Timens, W., van den Berge, M. & Brandsma, C.-A., 1-sep.-2016, In: European Respiratory Journal. 48, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis

  Spanjer, A. I. R., Menzen, M. H., Dijkstra, A. E., van den Berge, M., Boezen, H. M., Nickle, D. C., Sin, D. D., Bosse, Y., Brandsma, C.-A., Timens, W., Postma, D. S., Meurs, H., Heijink, I. H. & Gosens, R., apr.-2016, In: Thorax. 71, 4, blz. 312-322 11 blz.

  Onderzoeksoutput › Academic › peer review

  • Receptor 100%
  • Respiratory Tract Inflammation 100%
  • Chronic Bronchitis 100%
  • Acute Bronchitis 100%
  • Eicosanoid Receptor 100%
  20 Citaten (Scopus)

• Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17(+) Cells in Asthmatic Airways

  Fattahi, F., Brandsma, C.-A., Lodewijk, M., Reinders-Luinge, M., Postma, D. S., Timens, W., Hylkema, M. N. & Hacken, ten, N., 23-aug.-2016, In: PLoS ONE. 11, 8, 12 blz., e0161433.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Atopy 100%
  • Interleukin-17 (IL-17) 100%
  • Inhaled Corticosteroid Therapy 100%
  • Asthmatic Airways 100%
  • Interleukin 17 100%
  9 Citaten (Scopus)

  294 Downloads (Pure)

• Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer

  Pore, M., Meijer, C., de Bock, G. H., Boersma-van Ek, W., Terstappen, L. W. M. M., Groen, H. J. M., Timens, W., Kruyt, F. A. E. & Hiltermann, T. J. N., nov.-2016, In: Clinical lung cancer. 17, 6, blz. 535-542 8 blz.

  Onderzoeksoutput › Academic › peer review

  • Circulating Tumor Cell 100%
  • Small Cell Lung Cancer 100%
  • Cancer Stem Cell 100%
  • Malignant Neoplasm 100%
  • Neoplasm 100%
  34 Citaten (Scopus)

• Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer

  Saber, A., Wekken, van der, A., Kerner, G. S. M. A., van den Berge, M., Timens, W., Schuuring, E., Ter Elst, A., van den Berg, A., Hiltermann, T. J. N. & Groen, H. J. M., 23-mrt.-2016, In: PLoS ONE. 11, 3, 11 blz., e0152317.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • Chronic Obstructive Pulmonary Disease 100%
  • Non Small Cell Lung Cancer 100%
  • KRAS 100%
  • Growth Factor Receptor 100%
  • Chronic Obstructive Lung Disease 100%
  10 Citaten (Scopus)

  258 Downloads (Pure)

• Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma

  Nieuwenhuis, M. A., Siedlinski, M., van den Berge, M., Granell, R., Li, X., Niens, M., van der Vlies, P., Altmueller, J., Nuernberg, P., Kerkhof, M., van Schayck, O. C., Riemersma, R. A., van der Molen, T., de Monchy, J. G., Bosse, Y., Sandford, A., Bruijnzeel-Koomen, C. A., Gerth van Wijk, R., ten Hacken, N. H. & Timens, W. & 6 anderen, Boezen, H. M., Henderson, J., Kabesch, M., Vonk, J. M., Postma, D. S. & Koppelman, G. H., dec.-2016, In: Allergy. 71, 12, blz. 1712-1720 9 blz.

  Onderzoeksoutput › Academic › peer review

  • Asthma 100%
  • Single-Nucleotide Polymorphism 100%
  • Single Nucleotide Polymorphism 80%
  • Genome Wide Association Study 50%
  • Genetic Determinism 8%
  45 Citaten (Scopus)

• Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations

  Fehringer, G., Kraft, P., Pharoah, P. D., Eeles, R. A., Chatterjee, N., Schumacher, F. R., Schildkraut, J. M., Lindstrom, S., Brennan, P., Bickeboller, H., Houlston, R. S., Landi, M. T., Caporaso, N., Risch, A., Al Olama, A. A., Berndt, S. I., Giovannucci, E. L., Gronberg, H., Kote-Jarai, Z. & Ma, J. & 36 anderen, Muir, K., Stampfer, M. J., Stevens, V. L., Wiklund, F., Willett, W. C., Goode, E. L., Permuth, J. B., Risch, H. A., Reid, B. M., Bezieau, S., Brenner, H., Chan, A. T., Chang-Claude, J., Hudson, T. J., Kocarnik, J. K., Newcomb, P. A., Schoen, R. E., Slattery, M. L., White, E., Adank, M. A., Ahsan, H., Aittomaki, K., Baglietto, L., Blomquist, C., Canzian, F., Czene, K., dos-Santos-Silva, I., Eliassen, A. H., Figueroa, J. D., Timens, W., OCAC, PRACTICAl Consortium, Hereditary Breast Ovarian Canc Res, Colorectal Transdisciplinary, African Amer Breast Canc & African Ancestry Prostate Canc, 1-sep.-2016, In: Cancer Research. 76, 17, blz. 5103-5114 12 blz.

  Onderzoeksoutput › Academic › peer review

  • Genome-Wide Association Study 100%
  • Gene Expression 100%
  • Genetic Divergence 100%
  • Genome Wide Association Study 100%
  • Pleiotropy 100%
  96 Citaten (Scopus)

• Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage

  Szulcek, R., Happe, C. M., Rol, N., Fontijn, R. D., Dickhoff, C., Hartemink, K. J., Grunberg, K., Tu, L., Timens, W., Nossent, G. D., Paul, M. A., Leyen, T. A., Horrevoets, A. J., de Man, F. S., Guignabert, C., Yu, P. B., Vonk-Noordegraaf, A., Amerongen, G. P. V. N. & Bogaard, H. J., 15-jun.-2016, In: American Journal of Respiratory and Critical Care Medicine. 193, 12, blz. 1410-1420 11 blz.

  Onderzoeksoutput › Academic › peer review

  • Platelet 100%
  • Cell Adhesion Molecule 1 100%
  • Pulmonary Hypertension 100%
  • Platelet Endothelial Cell Adhesion Molecule 1 100%
  • Shear Stress 80%
  77 Citaten (Scopus)

• Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

  Schieck, M., Schouten, J. P., Michel, S., Suttner, K., Toncheva, A. A., Gaertner, V. D., Illig, T., Lipinski, S., Franke, A., Klintschar, M., Kalayci, O., Sahiner, U. M., Birben, E., Melen, E., Pershagen, G., Freidin, M. B., Ogorodova, L. M., Granell, R., Henderson, J. & Brunekreef, B. & 16 anderen, Smit, H. A., Vogelberg, C., von Berg, A., Bufe, A., Heinzmann, A., Laub, O., Rietschel, E., Simma, B., Genuneit, J., Jonigk, D., Postma, D. S., Koppelman, G. H., Vonk, J. M., Timens, W., Boezen, H. M. & Kabesch, M., aug.-2016, In: Journal of Allergy and Clinical Immunology. 138, 2, blz. 421-431 11 blz.

  Onderzoeksoutput › Academic › peer review

  • Genetics 100%
  • Macrophage 100%
  • Transcription Factors 100%
  • Doublesex 100%
  • Asthma 100%
  19 Citaten (Scopus)

• Effects of ICS/LABA treatment on hyperinflation and genome wide gene-expression in upper airway epithelium in severe COPD

  Imkamp, K., Faiz, A., van der Wiel, E., Boudewijn, I., Koppelman, G., Brandsma, C.-A., Kerstjens, H., Timens, W., Vroegop, S., Pasma, H., Boersma, W., Wielders, P., van den Elshout, F., Mansour, K., Steiling, K., Spira, A., Lenburg, M., Heijink, I., Postma, D. & van den Berge, M., 1-sep.-2016, In: European Respiratory Journal. 48, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Endothelial follistatin-like 1 regulates the maturation of the pulmonary vasculature by modulating BMP/SMAD signaling

  Tania, N. P., Maarsingh, H., Bos, S. T., Mattiotti, A., Prakash, S., Timens, W., Schmidt, M., Van Den Hoff, M. & Gosens, R., 1-apr.-2016, In: The FASEB Journal. 30, 1 Supplement, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

  • Maturation 100%
  • Vascularization 100%
  • Bone Morphogenetic Protein 100%
  • Follistatin 100%
  • SMAD 100%

• Fibulin-5 as a potential therapeutic target in COPD

  Brandsma, C.-A., van den Berge, M., Postma, D. & Timens, W., 2016, In: EXPERT OPINION ON THERAPEUTIC TARGETS. 20, 9, blz. 1031-1033 3 blz.

  Onderzoeksoutput: Editorial › Academic › peer review
  5 Citaten (Scopus)

• FKBP5 a candidate for corticosteroid insensitivity in COPD

  Faiz, A., Postma, D. S., Koppelman, G. H., Hiemstra, P. S., Sterk, P. J., Timens, W., Steiling, K., Spira, A., Heijink, I. H. & van den Berge, M., 1-sep.-2016, In: European Respiratory Journal. 48, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Genetic Regulation Of Gene Expression Changes In COPD

  Brandsma, C.-A., Faiz, A., Postma, D. S., Pare, P. D., Sin, D. D., Bosse, Y., Laviolette, M., Nickle, D. C., Hao, K., Timens, W. & Van den Berge, M., 2016, In: American Journal of Respiratory and Critical Care Medicine. 193, 1 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing

  Saber, A., van der Wekken, A. J., Kok, K., Terpstra, M. M., Bosman, L. J., Mastik, M. F., Timens, W., Schuuring, E., Hiltermann, T. J. N., Groen, H. J. M. & van den Berg, A., 5-apr.-2016, In: PLoS ONE. 11, 4, 12 blz., e0153065.

  Onderzoeksoutput › Academic › peer review

  Open Access

  Bestand

  • RNA Sequencing 100%
  • Crizotinib 100%
  • Fusion Gene 100%
  • Crizotinib-resistant 100%
  • ALK mutation 25%
  13 Citaten (Scopus)

  255 Downloads (Pure)

• Identification Of Micrornas That Potentially Regulate Chronic Mucus Hypersecretion In COPD

  Tasena, H., Van den Berge, M., Faiz, A., Postma, D. S., Timens, W., Hylkema, M., Hiemstra, P. S., Sterk, P. J., Heijink, I. H. & Brandsma, C.-A., 2016, In: American Journal of Respiratory and Critical Care Medicine. 193, 1 blz., B58.

  Onderzoeksoutput: Meeting Abstract › Academic

• Identification of NSCLC patients with high tumor glucose uptake by 18FFDG-PET

  Hendriks, A. M., Brouwers, A. H., Lefrandt, J. D., Sluiter, W. J., Timens, W., Groen, H. J. M., De Vries, E. G. E. & Jalving, M., 1-jan.-2016, In: Molecular Cancer Research. 14, 1 Supplement, 1 blz., Abstract nr A82.

  Onderzoeksoutput › Academic

  • Neoplasm 100%
  • Positron Emission Tomography 100%
  • Non Small Cell Lung Cancer 100%
  • Glucose Uptake 100%
  • Glucose Transport 100%

• Inducible Expression Quantitative Trait Loci: A Novel Method To Identifying Genetic Variants Associated With Corticosteroid Responsiveness In COPD

  Faiz, A., Postma, D. S., Koppelman, G. H., Hiemstra, P. S., Sterk, P. J., Timens, W., Steiling, K., Spira, A., Heijink, I. H. & Van den Berge, M., 2016, In: American Journal of Respiratory and Critical Care Medicine. 193, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Interleukin-1 alpha drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

  Osei, E. T., Noordhoek, J., Hackett, T. L., Spanjer, A. I. R., Postma, D. S., Timens, W., Brandsma, C.-A. & Heijink, I. H., 31-jul.-2016, In: European Respiratory Journal. 48, 2, blz. 359-369 11 blz.

  Onderzoeksoutput › Academic › peer review

  • Chronic Obstructive Pulmonary Disease 100%
  • Interleukin 1alpha 100%
  • Lung Fibroblast 100%
  • Fibroblast 100%
  • Interleukin-1 100%
  56 Citaten (Scopus)

• LSC Abstract - Inducible expression quantitative trait loci: A novel method to identifying genetic variants associated with corticosteroid responsiveness in COPD

  Faiz, A., Postma, D., Koppelman, G., Hiemstra, P., Sterk, P., Timens, W., Steiling, K., Spira, A., Heijink, I. & van den Berge, M., 1-sep.-2016, In: European Respiratory Journal. 48, 2 blz.

  Onderzoeksoutput: Meeting Abstract › Academic

• Lung Cancer Associations Are Enriched For Regulatory Variants In Non-Tumor Lung Tissue

  Obeidat, M., Nie, Y., Bosse, Y., Laviolette, M., Hao, K., Nickle, D. C., Postma, D. S., Timens, W., Hung, R. J., Lam, W. L., Vucic, E. A., Pare, P. D. & Sin, D. D., 2016, In: American Journal of Respiratory and Critical Care Medicine. 2 blz., B30.

  Onderzoeksoutput: Meeting Abstract › Academic

• MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD

  Leuenberger, C., Schuoler, C., Bye, H., Mignan, C., Rechsteiner, T., Hillinger, S., Opitz, I., Marsland, B., Faiz, A., Hiemstra, P. S., Timens, W., Camici, G. G., Kohler, M., Huber, L. C. & Brock, M., jun.-2016, In: Journal of Molecular Medicine. 94, 6, blz. 725-734 10 blz.

  Onderzoeksoutput › Academic › peer review

  • Epigenetics 100%
  • Mouse 100%
  • Chemokine 100%
  • Fractalkine 100%
  • Pulmonary Artery 100%
  40 Citaten (Scopus)

• Novel Genetic Susceptibility Loci for FEV1 in the Context of Occupational Exposure in Never-Smokers

  de Jong, K., Vonk, J. M., Faiz, A., van der Plaat, D., Timens, W., Bosse, Y., Kromhout, H., Nedeljkovic, I., Postma, D. S. & Boezen, H. M., 15-sep.-2016, In: American Journal of Respiratory and Critical Care Medicine. 194, 6, blz. 769-772 4 blz.

  Onderzoeksoutput › Academic › peer review
  1 Citaat (Scopus)

• PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations

  Scheel, A. H., Ansen, S., Schultheis, A. M., Scheffler, M., Fischer, R. N., Michels, S., Hellmich, M., George, J., Zander, T., Brockmann, M., Stoelben, E., Groen, H., Timens, W., Perner, S., von Bergwelt-Baildon, M., Buettner, R. & Wolf, J., 2016, In: OncoImmunology. 5, 5, 9 blz., 1131379.

  Onderzoeksoutput › Academic › peer review

  • Gene Mutation 100%
  • Non Small Cell Lung Cancer 100%
  • Programmed Death-Ligand 1 100%
  • PD-L1 100%
  • Tumor Cell 27%
  93 Citaten (Scopus)

• Potential role for an imbalance between airway smooth muscle laminin α4 and α5 expression in asthma

  Prabhala, P., Wright, D. B., ten Hacken, N. H. T., van den Berge, M., Postma, D. S., Timens, W., Meurs, H. & Dekkers, B. G. J., 2016, (Unpublished).

  Onderzoeksoutput: Poster › Academic