[18F]-Sodium fluoride uptake in Takayasu arteritis

E. Alexanderson-Rosas, A. G. Monroy-Gonzalez, Luis Eduardo Juarez-Orozco, M. M. Martinez-Aguilar, E. Estrada, I. Soldevilla, O. Garcia-Perez, M. E. Soto-Lopez*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    4 Citaten (Scopus)

    Samenvatting

    BACKGROUND: While (18)F-fluorodeoxyglucose and (18)F-sodium fluoride with positron emission tomography relate with inflammation and calcification, their role in the assessment of patients with Takayasu arteritis has not yet been studied.

    METHODS: We present 5 patients with suspected active metabolic disease who underwent PET with (18)F-fluorodeoxyglucose and (18)F-sodium fluoride in order to explore the locations and correlations of (18)F-fluorodeoxyglucose and (18)F-sodium fluoride uptakes. Diagnosis of metabolic active disease was based on (18)F-fluorodeoxyglucose uptake.

    RESULTS: We studied 3 female patients and 2 male patients. Median age was 29 years (min: 19 max: 63). In areas with atherosclerotic plaques, we found a negative correlation between (18)F-sodium fluoride and (18)F-fluorodeoxyglucose uptakes (r = -0.78) (P = .001). Meanwhile, in areas with only metabolic active disease, we found a positive correlation between (18)F-sodium fluoride and (18)F-fluorodeoxyglucose uptakes (r = 0.94) (P = .019).

    CONCLUSIONS: In Takayasu arteritis, (18)F-sodium fluoride uptake can document different stages of metabolic disease, even in the absence of active metabolic disease or symptoms.

    Originele taal-2English
    Pagina's (van-tot)1674-1679
    Aantal pagina's6
    TijdschriftJournal of Nuclear Cardiology
    Volume24
    Nummer van het tijdschrift5
    DOI's
    StatusPublished - okt.-2017

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