6-methylprednisolone does not impair anti-thymocyte globulin (ATG) immunosuppressive activity in non-human primates

[No Value] Preville, E Sick, S Beauchard, M Ossevoort, J Tiollier, JP Revillard, Margreet Jonker

OnderzoeksoutputAcademicpeer review

5 Citaten (Scopus)

Samenvatting

Background: Induction treatments with anti-thymocyte globulin (ATG) in solid organ transplantation may enhance the efficacy of maintenance immunosuppressive therapy. Since ATG can trigger Fas (CD95) mediated T cell apoptosis, a process antagonized in vitro by corticosteroids, an important issue is whether corticosteroids could interfere with T cell depleting and immunosuppressive activities of ATG. Methods: MHC mismatched skin allografts were performed on cynomolgus and rhesus monkeys treated with ATG (20 mg/kg) associated or not with 6-methylprednisolone (10 mg/kg). Results. There was no difference between the two immunosuppressive regimens as regards the intensity and duration of peripheral T lymphocyte depletion and the appearance of anti-ATG antibodies. Skin graft survival was increased in monkeys treated with 6-methylprednisolone as compared with ATG alone. Conclusions: In vivo, corticosteroids do not interfere with ATG ability to induce massive T cell depletion and to delay skin allograft rejection in non-human primates. (C) 2001 Elsevier Science B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)57-61
Aantal pagina's5
TijdschriftTransplant immunology
Volume9
Nummer van het tijdschrift1
StatusPublished - okt-2001

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