A cardiovascular life history - A life course analysis of the original Framingham Heart Study cohort

A Peeters*, AA Mamun, F Willekens, L Bonneux, NEDCOM

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    128 Citaten (Scopus)


    Aims. The objective of this paper is to measure the potential burden of cardiovascular disease within the original Framingham Heart Study cohort by transforming its well-described epidemiological measures into time-based health policy measures, such as life years lost to or lived with the disease.

    Methods and Results. We constructed multi-state life tables of the Framingham Heart Study cohort to calculate dwelling times with a history of cardiovascular disease. Age-specific probabilities determined transitions from healthy through disease to death. For this synthetic cohort, from age 50 men (women) live on average 26 (32) years, 20 (26) free of cardiovascular disease. Allowing occupancy of more than one disease state. 50-year-old males (females) live 2(.)9 (1(.)2) years with a history of myocardial infarction, 0(.)93 (1(.)2) with a history of stroke, and 0(.)67 (0(.)3) with congestive heart failure. Having ever suffered acute myocardial infarction, stroke or congestive heart failure, life expectancy is reduced by 9 (13), 12 (15) or 16 (16) years, respectively in 60-year-oid men (women).

    Conclusions. Transforming occurrence probabilities into time-based health measures, the prevalence of cardiovascular disease is remarkable: from age 50, 20% of remaining life expectancy is lived with the disease. Such measures are integral to appropriate health planning and assessment of the potential population health value of various treatment and prevention strategies.

    Originele taal-2English
    Pagina's (van-tot)458-466
    Aantal pagina's9
    TijdschriftEuropean Heart Journal
    Nummer van het tijdschrift6
    StatusPublished - mrt-2002

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