A clinical and economic assessment of adjuvanted trivalent versus standard egg-derived quadrivalent influenza vaccines among older adults in the United States during the 2018-19 and 2019-20 influenza seasons

Myron J. Levin, Victoria Divino, Maarten J. Postma, Stephen I. Pelton, Zifan Zhou, Mitch DeKoven, Joaquin Mould-Quevedo*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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Samenvatting

Background: Clinical evidence supports use of enhanced influenza vaccines in older adults. Few economic outcome studies have compared adjuvanted trivalent inactivated (aIIV3) and standard egg-derived quadrivalent inactivated influenza vaccines (IIV4e). 

Research Design and Methods: A retrospective cohort study was conducted leveraging deidentified US hospital data linked to claims data during the 2018–19 and 2019–20 influenza seasons. Relative vaccine effectiveness (rVE) was compared in adults aged ≥ 65 years receiving aIIV3 or IIV4e using inverse probability of treatment weighting (IPTW) and Poisson regression. An economic assessment quantified potential real-world cost savings. 

Results: The study included 715,807 aIIV3 and 320,991 IIV4e recipients in the 2018–19 and 844,169 aIIV3 and 306,270 IIV4e recipients in the 2019–20 influenza seasons. aIIV3 was significantly more effective than IIV4e in preventing cardiorespiratory disease (2018–19 rVE = 6.2%; and 2019–20 rVE = 6.0%) and respiratory disease (2018–19 rVE = 8.9%; and 2019–20 rVE = 10.1%). During the 2018–19 influenza season cardiorespiratory hospitalization cost savings for the aIIV3 population were $392 M, and $221 M for the 2019–20 season. Respiratory hospitalization cost savings for the aIIV3 population were $145 M and $97 M, respectively. 

Conclusions: Our findings suggest that aIIV3 provides clinical and economic advantages versus IIV4e in the elderly.

Originele taal-2English
Pagina's (van-tot)124-136
Aantal pagina's13
TijdschriftExpert review of vaccines
Volume23
Nummer van het tijdschrift1
DOI's
StatusPublished - 2024

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