A computational study on the nature of DNA G-quadruplex structure

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DNA G-quadruplexes are higher-order structures self-assembled from guanine-rich oligonucleotides.
These DNA structures are composed of stacked planar G-quartets, a cyclic Hoogsteen
hydrogen bonding arrangement of four guanine bases, that are stabilized in the
presence of monovalent cations. The identification of G-quadruplex structures in the
human genome, particularly telomeres and oncogene-promoter regions offer unique avenues to selectively target these structures for anticancer drug development. In addition, G-quadruplex structures have attracted considerable attention for their regulatory roles in cellular processes including DNA replication, transcription, and translation. Apart from the therapeutics and biology, the unique structure of the G-quadruplex makes it an interesting building blocks for the development of nanodevices. The aim of this thesis is to investigate different aspects of G-quadruplex based systems for these applications with the aid of computational techniques.
Originele taal-2English
KwalificatieDoctor of Philosophy
Toekennende instantie
  • Rijksuniversiteit Groningen
Begeleider(s)/adviseur
  • Faraji, Shirin, Supervisor
  • Marrink, Siewert, Supervisor
  • de Vries, Alex, Co-supervisor
  • Dreuw, Andreas, Beoordelingscommissie, Externe Persoon
  • Borschevsky, Anastasia, Beoordelingscommissie
  • Chiechi, Ryan, Beoordelingscommissie
Datum van toekenning19-mrt-2021
Plaats van publicatie[Groningen]
Uitgever
DOI's
StatusPublished - 2021

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