A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy

Alaa Alkhalaf; Astrid Klooster; Willem van Oeveren; Ulrike Achenbach; Nanne Kleefstra; Robbert J. Slingerland; G. Sophie Mijnhout; Henk J. G. Bilo; Reinold O. B. Gans; Gerjan J. Navis; Stephan J. L. Bakker

doi:10.2337/dc09-2241

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy

Alaa Alkhalaf^*, Astrid Klooster, Willem van Oeveren, Ulrike Achenbach, Nanne Kleefstra, Robbert J. Slingerland, G. Sophie Mijnhout, Henk J. G. Bilo, Reinold O. B. Gans, Gerjan J. Navis, Stephan J. L. Bakker

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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OBJECTIVE - To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy.

RESEARCH DESIGN AND METHODS - Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43).

RESULTS - Compared with placebo, benfotiamine treatment resulted in significant improvement of thiamine status (P <0.001). Benfotiamine treatment did not significantly decrease 24-h UAE or 24-h KIM-1 excretion.

CONCLUSIONS - In patients with type 2 diabetes and nephropathy, high-dose benfotiamine treatment for 12 weeks in addition to ACE-Is or ARBs did not reduce UAE or KIM-1 excretion, despite improvement of thiamine status.

Originele taal-2	English
Pagina's (van-tot)	1598-1601
Aantal pagina's	4
Tijdschrift	Diabetes Care
Volume	33
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.2337/dc09-2241
Status	Published - jul.-2010

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Alkhalaf, A., Klooster, A., van Oeveren, W., Achenbach, U., Kleefstra, N., Slingerland, R. J., Mijnhout, G. S., Bilo, H. J. G., Gans, R. O. B., Navis, G. J., & Bakker, S. J. L. (2010). A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy. Diabetes Care, 33(7), 1598-1601. https://doi.org/10.2337/dc09-2241

@article{634d6a5ff42a4126afaa076ac98e13b5,

title = "A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy",

abstract = "OBJECTIVE - To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy.RESEARCH DESIGN AND METHODS - Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43).RESULTS - Compared with placebo, benfotiamine treatment resulted in significant improvement of thiamine status (P <0.001). Benfotiamine treatment did not significantly decrease 24-h UAE or 24-h KIM-1 excretion.CONCLUSIONS - In patients with type 2 diabetes and nephropathy, high-dose benfotiamine treatment for 12 weeks in addition to ACE-Is or ARBs did not reduce UAE or KIM-1 excretion, despite improvement of thiamine status.",

keywords = "HIGH-DOSE THIAMINE, DISEASE, DAMAGE",

author = "Alaa Alkhalaf and Astrid Klooster and {van Oeveren}, Willem and Ulrike Achenbach and Nanne Kleefstra and Slingerland, {Robbert J.} and Mijnhout, {G. Sophie} and Bilo, {Henk J. G.} and Gans, {Reinold O. B.} and Navis, {Gerjan J.} and Bakker, {Stephan J. L.}",

note = "Article",

year = "2010",

month = jul,

doi = "10.2337/dc09-2241",

language = "English",

volume = "33",

pages = "1598--1601",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "AMER DIABETES ASSOC",

number = "7",

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TY - JOUR

T1 - A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy

AU - Alkhalaf, Alaa

AU - Klooster, Astrid

AU - van Oeveren, Willem

AU - Achenbach, Ulrike

AU - Kleefstra, Nanne

AU - Slingerland, Robbert J.

AU - Mijnhout, G. Sophie

AU - Bilo, Henk J. G.

AU - Gans, Reinold O. B.

AU - Navis, Gerjan J.

AU - Bakker, Stephan J. L.

N1 - Article

PY - 2010/7

Y1 - 2010/7

N2 - OBJECTIVE - To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy.RESEARCH DESIGN AND METHODS - Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43).RESULTS - Compared with placebo, benfotiamine treatment resulted in significant improvement of thiamine status (P <0.001). Benfotiamine treatment did not significantly decrease 24-h UAE or 24-h KIM-1 excretion.CONCLUSIONS - In patients with type 2 diabetes and nephropathy, high-dose benfotiamine treatment for 12 weeks in addition to ACE-Is or ARBs did not reduce UAE or KIM-1 excretion, despite improvement of thiamine status.

AB - OBJECTIVE - To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy.RESEARCH DESIGN AND METHODS - Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43).RESULTS - Compared with placebo, benfotiamine treatment resulted in significant improvement of thiamine status (P <0.001). Benfotiamine treatment did not significantly decrease 24-h UAE or 24-h KIM-1 excretion.CONCLUSIONS - In patients with type 2 diabetes and nephropathy, high-dose benfotiamine treatment for 12 weeks in addition to ACE-Is or ARBs did not reduce UAE or KIM-1 excretion, despite improvement of thiamine status.

KW - HIGH-DOSE THIAMINE

KW - DISEASE

KW - DAMAGE

U2 - 10.2337/dc09-2241

DO - 10.2337/dc09-2241

M3 - Article

SN - 0149-5992

VL - 33

SP - 1598

EP - 1601

JO - Diabetes Care

JF - Diabetes Care

IS - 7

ER -

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy

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