@article{4fbcdf97a23944a790386f4d3c2df849,
title = "A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans",
abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",
keywords = "STAGE RENAL-DISEASE, LARGE-SCALE ASSOCIATION, SUSCEPTIBILITY LOCI, INSULIN-RESISTANCE, FASTING GLUCOSE, TISSUE FACTOR, HOMEODOMAIN PROTEIN, LINKAGE ANALYSIS, COMMON VARIANTS, TCF7L2 GENE",
author = "Palmer, {Nicholette D.} and McDonough, {Caitrin W.} and Hicks, {Pamela J.} and Roh, {Bong H.} and Wing, {Maria R.} and An, {S. Sandy} and Hester, {Jessica M.} and Cooke, {Jessica N.} and Bostrom, {Meredith A.} and Rudock, {Megan E.} and Talbert, {Matthew E.} and Lewis, {Joshua P.} and Assiamira Ferrara and Lingyi Lu and Ziegler, {Julie T.} and Sale, {Michele M.} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, {Charles N.} and Ng, {Maggie C. Y.} and Langefeld, {Carl D.} and Freedman, {Barry I.} and Bowden, {Donald W.} and {DIAGRAM Consortium} and {MAGIC Investigators} and Cisca Wijmenga and {Vliet-Ostaptchouk, van}, Jana",
year = "2012",
month = jan,
day = "4",
doi = "10.1371/journal.pone.0029202",
language = "English",
volume = "7",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "PUBLIC LIBRARY SCIENCE",
number = "1",
}