A linear mixed-model approach to study multivariate gene-environment interactions

BIOS Consortium

OnderzoeksoutputAcademicpeer review

86 Citaten (Scopus)


Different exposures, including diet, physical activity, or external conditions can contribute to genotype-environment interactions (GxE). Although high-dimensional environmental data are increasingly available and multiple exposures have been implicated with GxE at the same loci, multi-environment tests for GxE are not established. Here, we propose the structured linear mixed model (StructLMM), a computationally efficient method to identify and characterize loci that interact with one or more environments. After validating our model using simulations, we applied StructLMM to body mass index in the UK Biobank, where our model yields previously known and novel GxE signals. Finally, in an application to a large blood eQTL dataset, we demonstrate that StructLMM can be used to study interactions with hundreds of environmental variables.

Originele taal-2English
Pagina's (van-tot)180-186
Aantal pagina's10
TijdschriftNature Genetics
Nummer van het tijdschrift1
StatusPublished - jan.-2019


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