TY - JOUR
T1 - A metabolic perspective of the neutrophil life cycle
T2 - new avenues in immunometabolism
AU - Thind, Mehakpreet K.
AU - Uhlig, Holm H.
AU - Glogauer, Michael
AU - Palaniyar, Nades
AU - Bourdon, Celine
AU - Gwela, Agnes
AU - Lancioni, Christina L.
AU - Berkley, James A.
AU - Bandsma, Robert H.J.
AU - Farooqui, Amber
N1 - Publisher Copyright:
Copyright © 2024 Thind, Uhlig, Glogauer, Palaniyar, Bourdon, Gwela, Lancioni, Berkley, Bandsma and Farooqui.
PY - 2023/1/8
Y1 - 2023/1/8
N2 - Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways for biosynthesis and bioenergetics for mediating biological processes such as development in the bone marrow and antimicrobial activity such as ROS production and NET formation, inflammation and tissue repair. We first discuss recent work on neutrophil development and functions and the metabolic processes to regulate granulopoiesis, neutrophil migration and trafficking as well as effector functions. We then discuss metabolic syndromes with impaired neutrophil functions that are influenced by genetic and environmental factors of nutrient availability and usage. Here, we particularly focus on the role of specific macronutrients, such as glucose, fatty acids, and protein, as well as micronutrients such as vitamin B3, in regulating neutrophil biology and how this regulation impacts host health. A special section of this review primarily discusses that the ways nutrient deficiencies could impact neutrophil biology and increase infection susceptibility. We emphasize biochemical approaches to explore neutrophil metabolism in relation to development and functions. Lastly, we discuss opportunities and challenges to neutrophil-centered therapeutic approaches in immune-driven diseases and highlight unanswered questions to guide future discoveries.
AB - Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways for biosynthesis and bioenergetics for mediating biological processes such as development in the bone marrow and antimicrobial activity such as ROS production and NET formation, inflammation and tissue repair. We first discuss recent work on neutrophil development and functions and the metabolic processes to regulate granulopoiesis, neutrophil migration and trafficking as well as effector functions. We then discuss metabolic syndromes with impaired neutrophil functions that are influenced by genetic and environmental factors of nutrient availability and usage. Here, we particularly focus on the role of specific macronutrients, such as glucose, fatty acids, and protein, as well as micronutrients such as vitamin B3, in regulating neutrophil biology and how this regulation impacts host health. A special section of this review primarily discusses that the ways nutrient deficiencies could impact neutrophil biology and increase infection susceptibility. We emphasize biochemical approaches to explore neutrophil metabolism in relation to development and functions. Lastly, we discuss opportunities and challenges to neutrophil-centered therapeutic approaches in immune-driven diseases and highlight unanswered questions to guide future discoveries.
KW - autophagy
KW - glycolysis
KW - immune mediated diseases
KW - metabolic reprogramming
KW - mitochondrial respiration
KW - neutrophil differentiation
UR - http://www.scopus.com/inward/record.url?scp=85182638302&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2023.1334205
DO - 10.3389/fimmu.2023.1334205
M3 - Review article
C2 - 38259490
AN - SCOPUS:85182638302
SN - 1664-3224
VL - 14
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1334205
ER -