A metal ion regulated artificial metalloenzyme

Manuela Bersellini, Gerard Roelfes

OnderzoeksoutputAcademicpeer review

13 Citaten (Scopus)


Regulation of enzyme activity is essential in living cells. The rapidly increasing number of designer enzymes with new-to-nature activities makes it necessary to develop novel strategies for controlling their catalytic activity. Here we present the development of a metal ion regulated artificial metalloenzyme created by combining two anchoring strategies, covalent and supramolecular, for introducing a regulatory and a catalytic site, respectively. This artificial metalloenzyme is activated in the presence of Fe(2+) ions, but only marginally in the presence of Zn(2+).

Originele taal-2English
Pagina's (van-tot)4325-4330
Aantal pagina's6
TijdschriftDalton Transactions
Nummer van het tijdschrift13
StatusPublished - 2017

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