A multi-national comparison of antipsychotic drug use in children and adolescents, 2005-2012

Luuk J Kalverdijk, Christian J Bachmann, Lise Aagaard, Mehmet Burcu, Gerd Glaeske, Falk Hoffmann, Irene Petersen, Catharina C M Schuiling-Veninga, Linda P Wijlaars, Julie M Zito

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Samenvatting

Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006-2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands' data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15-19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries' cohorts.

Originele taal-2English
Artikelnummer55
Aantal pagina's9
TijdschriftChild and Adolescent Psychiatry Mental Health
Volume11
DOI's
StatusPublished - 11-okt-2017

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