The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.
Lei, X. (Contributor), Lampiri, P. (Contributor), Patil, P. (Contributor), Angeli, G. (Contributor), Neochoritis, C. G. (Contributor) & Dömling, A. (Contributor), The Cambridge Structural Database, 13-apr.-2021