A NEW PLLA PCL COPOLYMER FOR NERVE REGENERATION

WFA DENDUNNEN, JM SCHAKENRAAD, GJ ZONDERVAN, AJ PENNINGS, B VANDERLEI, PH ROBINSON

OnderzoeksoutputAcademicpeer review

88 Citaten (Scopus)

Samenvatting

The aim of this study is to evaluate the functional and cell biological applicability of a two-ply nerve guide constructed of a PLLA/PCL (i.e. poly-L-lactide and poly-epsilon-caprolactone) copolymer. To do so, we performed a cytotoxicity test, a subcutaneous biodegradation test and an in situ implantation study in the sciatic nerve of the rat. The nerve guide copolymer was found to be non-toxic, according to ISO/EN standards, and it showed a mild foreign body reaction and complete fibrous encapsulation after implantation. Onset of biodegradation of the inner layer was seen after one month of implantation. After 1 8 months of implantation complete fragmentation was observed, as well as a secondary inflammatory response. characterized by foreign body giant cell activity and phagocytosis of polymer debris. Recovery of both motor and sensory nerve function was observed in all nerve guides.

Originele taal-2English
Pagina's (van-tot)521-525
Aantal pagina's5
TijdschriftJournal of Materials Science-Materials in Medicine
Volume4
Nummer van het tijdschrift5
StatusPublished - sep-1993

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