A parametric geometry model of the aortic valve for subject-specific blood flow simulations using a resistive approach

Giorgia Pase*, Emiel Brinkhuis, Tanja de Vries, Jiri Kosinka, Tineke Willems, Cristobal Bertoglio

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)
23 Downloads (Pure)


Cardiac valves simulation is one of the most complex tasks in cardiovascular modeling. Fluid–structure interaction is not only highly computationally demanding but also requires knowledge of the mechanical properties of the tissue. Therefore, an alternative is to include valves as resistive flow obstacles, prescribing the geometry (and its possible changes) in a simple way, but, at the same time, with a geometry complex enough to reproduce both healthy and pathological configurations. In this work, we present a generalized parametric model of the aortic valve to obtain patient-specific geometries that can be included into blood flow simulations using a resistive immersed implicit surface (RIIS) approach. Numerical tests are presented for geometry generation and flow simulations in aortic stenosis patients whose parameters are extracted from ECG-gated CT images.
Originele taal-2English
Pagina's (van-tot)987–1002
Aantal pagina's16
TijdschriftBiomechanics and Modeling in Mechanobiology
Vroegere onlinedatum28-feb.-2023
StatusPublished - 2023

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