A proposed definition of the 'activity' of surface sites on lactose carriers for dry powder inhalation

Floris Grasmeijer*, Henderik W. Frijlink, Anne de Boer

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

23 Citaten (Scopus)

Samenvatting

A new definition of the activity of surface sites on lactose carriers for dry powder inhalation is proposed which relates to drug detachment during dispersion. The new definition is expected to improve the understanding of 'carrier surface site activity', which stimulates the unambiguous communication about this subject and may aid in the rational design and interpretation of future formulation studies. In contrast to the currently prevailing view on carrier surface site activity, it follows from the newly proposed definition that carrier surface site activity depends on more variables than just the physicochemical properties of the carrier surface. Because the term 'active sites' is ambiguous, it is recommended to use the term 'highly active sites' instead to denote carrier surface sites with a relatively high activity. © 2014 Elsevier B.V. All rights reserved.
Originele taal-2English
Pagina's (van-tot)102-104
Aantal pagina's3
TijdschriftEuropean Journal of Pharmaceutical Sciences
Volume56
Nummer van het tijdschrift1
DOI's
StatusPublished - 2-jun.-2014

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