A Senescence-Centric View of Aging: Implications for Longevity and Disease

M Borghesan, W M H Hoogaars, M Varela-Eirin, N Talma, M Demaria*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

26 Citaten (Scopus)
29 Downloads (Pure)

Samenvatting

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential. Here, we discuss recent evidence that implicates cellular senescence as a central regulatory mechanism of the aging process. We provide a comprehensive overview of age-associated pathologies in which cellular senescence has been implicated. We describe mechanisms by which senescent cells drive aging and diseases, and we discuss updates on exploiting these mechanisms as therapeutic targets. Finally, we critically analyze the use of senotherapeutics and their translation to the clinic, highlighting limitations and suggesting ideas for future applications and developments.

Originele taal-2English
Pagina's (van-tot)777-791
Aantal pagina's15
TijdschriftTrends in Cell Biology
Volume30
Nummer van het tijdschrift10
Vroegere onlinedatum13-aug-2020
DOI's
StatusPublished - okt-2020

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