A simple enantioconvergent and chemoenzymatic synthesis of optically active α-substituted amides

Wiktor Szymanski, Alja Westerbeek, Dick B. Janssen*, Ben L. Feringa

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

14 Citaten (Scopus)

Samenvatting

Simple and efficient: The combination of an enzymatic, enantioinverting reaction with simple follow-up processes allows the transformation of readily available racemic compounds into versatile chiral α-substituted amides. These important building blocks are prepared in high overall yield and enantiomeric excess; the elimination of intermediate purification steps results in a time- and cost-efficient process.
Originele taal-2English
Pagina's (van-tot)10712-10715
Aantal pagina's4
TijdschriftAngewandte Chemie - International Edition
Volume50
Nummer van het tijdschrift45
DOI's
StatusPublished - 2011

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