A sudden collapse: the disaggregation of amyloid fibres

Suzanne Couzijn; Ellen Aa Nollen

doi:10.15252/embj.2022111700

A sudden collapse: the disaggregation of amyloid fibres

Suzanne Couzijn, Ellen Aa Nollen^*

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

1 Citaat (Scopus)

87 Downloads (Pure)

Samenvatting

A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.

Originele taal-2	English
Artikelnummer	e111700
Aantal pagina's	3
Tijdschrift	The EMBO Journal
Volume	41
Vroegere onlinedatum	5-jul.-2022
DOI's	https://doi.org/10.15252/embj.2022111700
Status	Published - 2022

Toegang tot document

10.15252/embj.2022111700

A sudden collapseFinal publisher's version, 465 KBLicentie: Taverne

Handle.net

Permanente koppeling

Citeer dit

@article{17a61909c81349afaf924478cfbc2f70,

title = "A sudden collapse: the disaggregation of amyloid fibres",

abstract = "A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.",

author = "Suzanne Couzijn and Nollen, {Ellen Aa}",

note = "{\textcopyright} 2022 The Authors.",

year = "2022",

doi = "10.15252/embj.2022111700",

language = "English",

volume = "41",

journal = "The EMBO Journal",

issn = "0261-4189",

publisher = "Wiley",

}

TY - JOUR

T1 - A sudden collapse

T2 - the disaggregation of amyloid fibres

AU - Couzijn, Suzanne

AU - Nollen, Ellen Aa

PY - 2022

Y1 - 2022

N2 - A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.

AB - A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.

U2 - 10.15252/embj.2022111700

DO - 10.15252/embj.2022111700

M3 - Article

C2 - 35791595

SN - 0261-4189

VL - 41

JO - The EMBO Journal

JF - The EMBO Journal

M1 - e111700

ER -

A sudden collapse: the disaggregation of amyloid fibres

Samenvatting

Toegang tot document

Handle.net

Vingerafdruk

Citeer dit