A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide

Adriaan J Minnaard; Ruben Andringa; Niels de Kok; Arnold Driessen

doi:10.1002/anie.202104759

A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide

Adriaan J Minnaard^*, Ruben Andringa, Niels de Kok, Arnold Driessen

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

2 Citaten (Scopus)

12 Downloads (Pure)

Samenvatting

Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13 C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.

Originele taal-2	English
Pagina's (van-tot)	17497-17503
Tijdschrift	Angewandte Chemie (International ed. in English)
Volume	60
Nummer van het tijdschrift	32
Vroegere onlinedatum	30-apr-2021
DOI's	https://doi.org/10.1002/anie.202104759
Status	Published - 2-aug-2021

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10.1002/anie.202104759Licentie: CC BY-NC-ND

A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide Final publisher's version, 1,48 MBLicentie: CC BY-NC-ND

Citeer dit

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AB - Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13 C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.

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