Samenvatting
Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.
Originele taal-2 | English |
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Pagina's (van-tot) | 17497-17503 |
Aantal pagina's | 7 |
Tijdschrift | Angewandte Chemie (International ed. in English) |
Volume | 60 |
Nummer van het tijdschrift | 32 |
Vroegere onlinedatum | 30-apr.-2021 |
DOI's | |
Status | Published - 2-aug.-2021 |